Chitosan/polyethylene glycol diacrylate films as potential wound dressing material.

Michael addition reaction of Chitosan (CS) and polyethylene glycol diacrylate (PEGDA) was carried out successfully in acidic solution. Films with CS/PEGDA weight ratios from 100/0 to 0/100 in 10% increments were analyzed by Fourier transform infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and X-Ray Diffraction (XRD). Additionally, the films were characterized by measuring mechanical property, swelling property. The potential application of the CS/PEGDA film as wound dressing material was evaluated in vitro by using mouse fibroblasts (L929) as reference cell lines, indirect cytotoxicity assessment indicated that CS/PEGDA films were nontoxic to L929 cell.

[1]  R. Kannan,et al.  Improvement in ductility of chitosan through blending and copolymerization with PEG: FTIR investigation of molecular interactions. , 2003, Biomacromolecules.

[2]  Y Ikada,et al.  In vitro and in vivo degradation of films of chitin and its deacetylated derivatives. , 1997, Biomaterials.

[3]  S. T. Lee,et al.  Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing. , 2001, Biomaterials.

[4]  Eugene Khor,et al.  Implantable applications of chitin and chitosan. , 2003, Biomaterials.

[5]  K. Kit,et al.  Physical, mechanical, and antibacterial properties of chitosan/PEO blend films. , 2007, Biomacromolecules.

[6]  F. Mi,et al.  Preparation and characterization on mechanical and antibacterial properties of chitsoan/cellulose blends , 2004 .

[7]  T. Fujinaga,et al.  Topical formulations and wound healing applications of chitosan. , 2001, Advanced drug delivery reviews.

[8]  H. No,et al.  Antibacterial activity of chitosans and chitosan oligomers with different molecular weights. , 2002, International journal of food microbiology.

[9]  Y. Wan,et al.  Biodegradable polylactide/chitosan blend membranes. , 2006, Biomacromolecules.

[10]  R. Muzzarelli,et al.  Antimicrobial properties of N-carboxybutyl chitosan , 1990, Antimicrobial Agents and Chemotherapy.

[11]  S. Neau,et al.  In vitro degradation of chitosan by a commercial enzyme preparation: effect of molecular weight and degree of deacetylation. , 2001, Biomaterials.

[12]  R. Samuels.  Solid state characterization of the structure of chitosan films , 1981 .

[13]  T. Dantas,et al.  Effect of molecular weight and ionic strength on the formation of polyelectrolyte complexes based on poly(methacrylic acid) and chitosan. , 2006, Biomacromolecules.

[14]  T. Bunning,et al.  Characterization of chitosan and rare-earth-metal-ion doped chitosan films , 1997 .

[15]  Trong-Ming Don,et al.  Structures and thermal properties of chitosan‐modified poly(methyl methacrylate) , 2001 .