High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung

[1]  Lingyun Yu,et al.  SSBP1 Upregulation In Colorectal Cancer Regulates Mitochondrial Mass , 2019, Cancer management and research.

[2]  E. Giannoni,et al.  Lactate: A Metabolic Driver in the Tumour Landscape. , 2019, Trends in biochemical sciences.

[3]  Yibing Chen,et al.  Upregulation of mtSSB by interleukin‐6 promotes cell growth through mitochondrial biogenesis‐mediated telomerase activation in colorectal cancer , 2018, International journal of cancer.

[4]  T. Chan,et al.  Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas , 2018, Journal of the National Cancer Institute.

[5]  F. Costabile,et al.  Targeting mitochondria in cancer: current concepts and immunotherapy approaches , 2018, Translational research : the journal of laboratory and clinical medicine.

[6]  C. Dinardo,et al.  Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia , 2017, Current Hematologic Malignancy Reports.

[7]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[8]  Ashley V. Menk,et al.  Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia , 2016, Cancer Immunology Research.

[9]  Ludmila V. Danilova,et al.  Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures , 2016, Genome Biology.

[10]  C. Sander,et al.  Mitochondrial respiratory gene expression is suppressed in many cancers , 2016, eLife.

[11]  A. Hakimi,et al.  The head and neck cancer immune landscape and its immunotherapeutic implications. , 2016, JCI insight.

[12]  Chandra Sekhar Pedamallu,et al.  Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas , 2016, Nature Genetics.

[13]  F. Sanchez-Garcia,et al.  Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance , 2016, Front. Immunol..

[14]  P. Ng,et al.  SIFT missense predictions for genomes , 2015, Nature Protocols.

[15]  Xiaodong Zhou,et al.  Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes , 2015, Head & neck.

[16]  Martin L. Miller,et al.  Mitochondrial DNA copy number variation across human cancers , 2015, bioRxiv.

[17]  Sunit Das,et al.  IDH mutation in glioma: new insights and promises for the future. , 2014, JAMA neurology.

[18]  J. Myers,et al.  Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma , 2014, Head & neck.

[19]  G. Mills,et al.  Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. , 2014, Molecular cell.

[20]  W. Yung,et al.  IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma. , 2013, Neuro-oncology.

[21]  T. Guerrero,et al.  Metformin use and improved response to therapy in esophageal adenocarcinoma , 2013, Acta oncologica.

[22]  J. Skibber,et al.  Metformin use and improved response to therapy in rectal cancer , 2013, Cancer medicine.

[23]  A. Garden,et al.  Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century , 2013, Radiation oncology.

[24]  Y. Wang,et al.  Glycolytic Inhibition Alters Anaplastic Thyroid Carcinoma Tumor Metabolism and Improves Response to Conventional Chemotherapy and Radiation , 2012, Molecular Cancer Therapeutics.

[25]  J. Myers,et al.  Altered metabolism in head and neck squamous cell carcinoma: an opportunity for identification of novel biomarkers and drug targets , 2012, Head & neck.

[26]  Ge Zhou,et al.  Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status , 2012, Cancer.

[27]  K. Ang,et al.  TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence , 2011, Clinical Cancer Research.

[28]  Ge Zhou,et al.  Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells , 2011, Cancer.

[29]  G. Z. Rocha,et al.  Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth , 2011, Clinical Cancer Research.

[30]  Kevin Struhl,et al.  Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. , 2011, Cancer research.

[31]  K. Ang,et al.  Human papillomavirus and survival of patients with oropharyngeal cancer. , 2010, The New England journal of medicine.

[32]  P. Bork,et al.  A method and server for predicting damaging missense mutations , 2010, Nature Methods.

[33]  C. Bertolotto,et al.  Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. , 2010, Cancer research.

[34]  Chi V Dang,et al.  Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. , 2010, Cancer research.

[35]  Rajiv Sarin,et al.  Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects. , 2009, Journal of cancer research and therapeutics.

[36]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[37]  W. Westra,et al.  Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. , 2008, Journal of the National Cancer Institute.

[38]  R. Deberardinis,et al.  Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.

[39]  Brian J. Smith,et al.  Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. , 2007, International journal of radiation oncology, biology, physics.

[40]  D. Spitz,et al.  2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. , 2007, Cancer research.

[41]  G. Fiskum,et al.  A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability. , 2006, Cancer research.

[42]  M. Grace,et al.  Hazard Ratio in Clinical Trials , 2004, Antimicrobial Agents and Chemotherapy.

[43]  Jill P. Mesirov,et al.  Consensus Clustering: A Resampling-Based Method for Class Discovery and Visualization of Gene Expression Microarray Data , 2003, Machine Learning.

[44]  S. Swoap,et al.  Differential Expression of Mitochondrial DNA Replication Factors in Mammalian Tissues* , 1998, The Journal of Biological Chemistry.

[45]  M. Rocchi,et al.  Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. , 1995, Genomics.

[46]  O. Warburg.  [Origin of cancer cells]. , 1956, Oncologia.

[47]  Brandon J. Griffin,et al.  THE PRESENT STATUS AND FUTURE PROSPECTS , 2015 .

[48]  A. Garden,et al.  An evolution in demographics, treatment, and outcomes of oropharyngeal cancer at a major cancer center , 2013, Cancer.

[49]  Jill P. Mesirov,et al.  A resampling-based method for class discovery and visualization of gene expression microarray data , 2003 .