A volume-averaged model for acoustic streaming induced by focused ultrasound in soft porous media.

Equations describing acoustic streaming in soft, porous media driven by focused ultrasound are derived based on the assumption that acoustic waves pass through the porous material as if it were homogeneous. From these equations, a model that predicts the time-averaged flow on the macroscopic scale, as well as the advective transport of the trace components, is created. The model is used to perform simulations for different shapes of the focused ultrasound beam. For a given shape, and using the paraxial approximation for the ultrasound, the acoustic streaming is found to be linearly proportional to the applied ultrasound intensity, to the permeability of the porous material and to the attenuation coefficient, and inversely proportional to the liquid viscosity. Results from simulations are compared to a simplified expression stating that the dimensionless volumetric liquid flux is equal to the dimensionless acoustic radiation force. This approximation for the acoustic streaming is found to be reasonable near the beam axis for focused ultrasound beam shapes that are long in the axial direction, compared to their width. Finally, a comparison is made between the model and experimental results on acoustic streaming in a gel, and good agreement is found.

[1]  Baohong Yuan Interstitial fluid streaming in deep tissue induced by ultrasound momentum transfer for accelerating nanoagent transport and controlling its distribution , 2022, Physics in medicine and biology.

[2]  C. de Lange Davies,et al.  Ultrasound and microbubbles to beat barriers in tumors: improving delivery of nanomedicine. , 2021, Advanced drug delivery reviews.

[3]  O. Manor Acoustic flow in porous media , 2021, Journal of Fluid Mechanics.

[4]  P. Rattanadecho,et al.  Acoustic streaming effect on flow and heat transfer in porous tissue during exposure to focused ultrasound , 2020 .

[5]  B. Angelsen,et al.  Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors , 2020, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[6]  B. Angelsen,et al.  Effect of Acoustic Radiation Force on Displacement of Nanoparticles in Collagen Gels , 2020, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[7]  A. Hansen,et al.  Pore Network Modeling of the Effects of Viscosity Ratio and Pressure Gradient on Steady-State Incompressible Two-Phase Flow in Porous Media , 2019, Transport in Porous Media.

[8]  Julian R. Jones,et al.  Acoustic Streaming in a Soft Tissue Microenvironment. , 2019, Ultrasound in medicine & biology.

[9]  Raghu Raghavan,et al.  Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery , 2018, Journal of therapeutic ultrasound.

[10]  Elliott S. Wise,et al.  Rapid calculation of acoustic fields from arbitrary continuous-wave sources. , 2018, The Journal of the Acoustical Society of America.

[11]  O. Sapozhnikov,et al.  Modeling of the acoustic radiation force in elastography. , 2017, The Journal of the Acoustical Society of America.

[12]  E. Hæggström,et al.  Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound , 2015, Ultrasound in medicine & biology.

[13]  A. Sarvazyan,et al.  Time-reversal acoustics and ultrasound-assisted convection-enhanced drug delivery to the brain. , 2013, The Journal of the Acoustical Society of America.

[14]  W. Olbricht,et al.  Ultrasound-assisted convection-enhanced delivery to the brain in vivo with a novel transducer cannula assembly: laboratory investigation. , 2012, Journal of neurosurgery.

[15]  H. Nieminen,et al.  Ultrasonic transport of particles into articular cartilage and subchondral bone , 2012, 2012 IEEE International Ultrasonics Symposium.

[16]  Oleg A. Sapozhnikov,et al.  An exact solution to the Helmholtz equation for a quasi-Gaussian beam in the form of a superposition of two sources and sinks with complex coordinates , 2012 .

[17]  P. Marston Quasi-Gaussian beam analytical basis and comparison with an alternative approach (L). , 2011, The Journal of the Acoustical Society of America.

[18]  P. Marston Quasi-Gaussian Bessel-beam superposition: application to the scattering of focused waves by spheres. , 2011, The Journal of the Acoustical Society of America.

[19]  S. Whitaker Flow in porous media I: A theoretical derivation of Darcy's law , 1986 .

[20]  H. Brinkman A calculation of the viscous force exerted by a flowing fluid on a dense swarm of particles , 1949 .

[21]  H. O'neil Theory of Focusing Radiators , 1949 .

[22]  N. Riley Acoustic Streaming , 1998 .

[23]  Stephen Whitaker,et al.  A Simple Geometrical Derivation of the Spatial Averaging Theorem. , 1985 .

[24]  Wesley L. Nyborg,et al.  Acoustic Streaming due to Attenuated Plane Waves , 1953 .