Living Multiples: How Large-scale Scientific Data-mining Pursues Identity and Differences

This article responds to two problems confronting social and human sciences: how to relate to digital data, inasmuch as it challenges established social science methods; and how to relate to life sciences, insofar as they produce knowledge that impinges on our own ways of knowing. In a case study of proteomics, we explore how digital devices grapple with large-scale multiples – of molecules, databases, machines and people. We analyse one particular visual device, a cluster-heatmap, produced by scientists by mining data from a large number of experiments on human blood plasma proteins. These proteins make up a myriad multiple whose identity shifts in many ways. Rather than displaying data about proteins, the heatmap constructs a view of the differences and similarities between experiments. We find this attempt to construct a view on many things at once instructive in thinking about multiples more generally. Instead of flattening molecular ‘life itself’, this visual device superimposes layers of digital devices and techniques from a wide variety of disciplines. This layering suggests a different way of relating to the life sciences more generally: rather than what they know, how they know might be of use to social and human sciences when attending to multiplicities.

[1]  B. Latour,et al.  'The whole is always smaller than its parts': a digital test of Gabriel Tardes' monads. , 2012, The British journal of sociology.

[2]  F. Al-Shamali,et al.  Author Biographies. , 2015, Journal of social work in disability & rehabilitation.

[3]  D. Botstein,et al.  Cluster analysis and display of genome-wide expression patterns. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Andrew Abbott,et al.  Time Matters: On Theory and Method , 2001 .

[5]  Henrik Loodin,et al.  The politics of life itself Biomedicine, power, and subjectivity in the twenty-first century , 2009 .

[6]  I. Stengers,et al.  The Invention Of Modern Science , 2000 .

[7]  Roger Burrows,et al.  The Coming Crisis of Empirical Sociology , 2007, Sociology.

[8]  Robert Tibshirani,et al.  The Elements of Statistical Learning: Data Mining, Inference, and Prediction, 2nd Edition , 2001, Springer Series in Statistics.

[9]  Nikolas Rose,et al.  The Human Sciences in a Biological Age , 2013 .

[10]  P. Limbach,et al.  Principles of Proteomics , 2007 .

[11]  Robyn Braun,et al.  Truth Machine: The Contentious History of DNA Fingerprinting , 2010 .

[12]  G. S. Johnson,et al.  An Information-Intensive Approach to the Molecular Pharmacology of Cancer , 1997, Science.

[13]  Lennart Martens,et al.  Proteomics data validation: why all must provide data. , 2007, Molecular bioSystems.

[14]  Christopher D. Manning,et al.  Introduction to Information Retrieval , 2010, J. Assoc. Inf. Sci. Technol..

[15]  Jane Bennett Vibrant Matter: A Political Ecology of Things , 2010 .

[16]  Leland Wilkinson,et al.  The History of the Cluster Heat Map , 2009 .

[17]  D. Ruppert The Elements of Statistical Learning: Data Mining, Inference, and Prediction , 2004 .

[18]  A. Tsing,et al.  Friction: An Ethnography of Global Connection by Anna Lowenhaupt Tsing , 2009, Transforming Anthropology.

[19]  R. Aebersold,et al.  Proteomics: the first decade and beyond , 2003, Nature Genetics.

[20]  A. Mol The Body Multiple: Ontology in Medical Practice , 2003 .

[21]  Richard A. Harshman,et al.  Indexing by Latent Semantic Analysis , 1990, J. Am. Soc. Inf. Sci..

[22]  E. Husserl,et al.  Edmund Husserl's Origin of geometry, an introduction , 1978 .

[23]  Kevin C. Desouza,et al.  Information politics on the Web , 2007, J. Assoc. Inf. Sci. Technol..

[24]  Nikolas Rose,et al.  The Politics of Life Itself: Biomedicine, Power, and Subjectivity in the Twenty-First Century , 2006 .

[25]  J. Weinstein A Postgenomic Visual Icon , 2008, Science.

[26]  G. Omenn,et al.  Exploring the Human Plasma Proteome , 2005, Proteomics.

[27]  Pier Giorgio Righetti,et al.  Bioanalysis: Its past, present, and some future , 2004, Electrophoresis.

[28]  Lennart Martens,et al.  Analyzing large-scale proteomics projects with latent semantic indexing. , 2008, Journal of proteome research.

[29]  AC Grayling,et al.  Laboratory life Rebecca Lemov World as Laboratory: Exper , 2006, The Lancet.