Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells

[1]  A. Swart,et al.  The 11β-hydroxyandrostenedione pathway and C11-oxy C21 backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone , 2020, The Journal of Steroid Biochemistry and Molecular Biology.

[2]  Tanya Stoyanova,et al.  Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer , 2019, Front. Oncol..

[3]  Z. Wawrzak,et al.  Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32 , 2019, The Journal of Biological Chemistry.

[4]  A. Goodman,et al.  Mapping human microbiome drug metabolism by gut bacteria and their genes , 2019, Nature.

[5]  V. Thackray Sex, Microbes, and Polycystic Ovary Syndrome , 2019, Trends in Endocrinology & Metabolism.

[6]  S. Hapfelmeier,et al.  In vitro and in vivo characterization of Clostridium scindens bile acid transformations , 2018, Gut microbes.

[7]  S. Devendran,et al.  The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase[S] , 2018, Journal of Lipid Research.

[8]  S. Seah,et al.  Characterization of an Aldolase Involved in Cholesterol Side Chain Degradation in Mycobacterium tuberculosis , 2017, Journal of bacteriology.

[9]  C. Huttenhower,et al.  The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: A Prospective, Pilot Study. , 2018, Urology.

[10]  A. Partin,et al.  Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer , 2018, The Journal of urology.

[11]  G. Nolan,et al.  A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites , 2017, Nature.

[12]  J. Ridlon,et al.  Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era , 2017, Steroids.

[13]  R. Auchus,et al.  Clinical significance of 11-oxygenated androgens , 2017, Current opinion in endocrinology, diabetes, and obesity.

[14]  S. Devendran,et al.  Identification and characterization of a 20β-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058[S] , 2017, Journal of Lipid Research.

[15]  K. Storbeck,et al.  A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids , 2017, Molecular and Cellular Endocrinology.

[16]  K. Storbeck,et al.  11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome , 2016, The Journal of clinical endocrinology and metabolism.

[17]  K. Storbeck,et al.  11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored , 2016, PloS one.

[18]  H. Nielsen,et al.  Capturing One of the Human Gut Microbiome’s Most Wanted: Reconstructing the Genome of a Novel Butyrate-Producing, Clostridial Scavenger from Metagenomic Sequence Data , 2016, Front. Microbiol..

[19]  Peter J. Turnbaugh,et al.  The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism , 2016, Nature Reviews Microbiology.

[20]  P. Swart,et al.  Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas , 2015, The Journal of Steroid Biochemistry and Molecular Biology.

[21]  J. Honour Historical perspective: gut dysbiosis and hypertension. , 2015, Physiological genomics.

[22]  K. Storbeck,et al.  11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways , 2015, Molecular and Cellular Endocrinology.

[23]  T. Jorgensen,et al.  Suppressive effects of androgens on the immune system. , 2015, Cellular immunology.

[24]  Chris Sander,et al.  Precision microbiome restoration of bile acid-mediated resistance to Clostridium difficile , 2014, Nature.

[25]  E. Mostaghel Beyond T and DHT - Novel Steroid Derivatives Capable of Wild Type Androgen Receptor Activation , 2014, International journal of biological sciences.

[26]  G. Buck,et al.  Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens , 2013, Journal of Lipid Research.

[27]  J. Marchesi,et al.  The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults , 2013, Front. Cell. Infect. Microbiol..

[28]  A. Pozzi,et al.  Epithelial-Specific Deletion of 11β-HSD2 Hinders Apcmin/+ Mouse Tumorigenesis , 2013, Molecular Cancer Research.

[29]  D. Huson,et al.  Dendroscope 3: an interactive tool for rooted phylogenetic trees and networks. , 2012, Systematic biology.

[30]  W. Rainey,et al.  The steroid metabolome of adrenarche. , 2012, The Journal of endocrinology.

[31]  J. Rosenberg,et al.  Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer , 2012, Drug design, development and therapy.

[32]  D. Higgins,et al.  Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega , 2011, Molecular systems biology.

[33]  K. Honda,et al.  Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species , 2011, Science.

[34]  Paramvir S. Dehal,et al.  FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments , 2010, PloS one.

[35]  Ning Ma,et al.  BLAST+: architecture and applications , 2009, BMC Bioinformatics.

[36]  C. Stournaras,et al.  Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo , 2009, Molecular Cancer.

[37]  C. Shackleton,et al.  17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites , 2008, Steroids.

[38]  Dae-Joong Kang,et al.  Bile salt biotransformations by human intestinal bacteria Published, JLR Papers in Press, November 18, 2005. , 2006, Journal of Lipid Research.

[39]  N. Fortunati,et al.  Altered expression of androgen‐receptor isoforms in human colon‐cancer tissues , 2000, International journal of cancer.

[40]  P. Hylemon,et al.  Isolation and characterization of cholic acid 7alpha-dehydroxylating fecal bacteria from cholesterol gallstone patients. , 2000, Journal of hepatology.

[41]  G. Jenster,et al.  The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[42]  J. Simard,et al.  Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells. , 1991, Cancer research.

[43]  P. Hylemon,et al.  Purification and characterization of a novel form of 20 alpha-hydroxysteroid dehydrogenase from Clostridium scindens , 1989, Journal of bacteriology.

[44]  V. Bokkenheuser,et al.  Cofactor requirements of steroid-17-20-desmolase and 20 alpha-hydroxysteroid dehydrogenase activities in cell extracts of Clostridium scindens. , 1987, Journal of steroid biochemistry.

[45]  V. Bokkenheuser,et al.  Steroid desmolase synthesis by Eubacterium desmolans and Clostridium cadavaris , 1986, Applied and environmental microbiology.

[46]  E. Itagaki Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization. , 1986, Journal of biochemistry.

[47]  E. Mosbach,et al.  Mode of action of steroid desmolase and reductases synthesized by Clostridium "scindens" (formerly Clostridium strain 19). , 1984, Journal of lipid research.

[48]  A. E. Ritchie,et al.  Biosynthesis of androgen from cortisol by a species of Clostridium recovered from human fecal flora. , 1984, The Journal of infectious diseases.

[49]  E. Mosbach,et al.  Side-chain cleavage of cortisol by fecal flora. , 1981, Biochimica et biophysica acta.

[50]  J. Gustafsson,et al.  Excretion of steroid hormones in adults. Steroids in faeces from adults. , 1971, European journal of biochemistry.

[51]  C. Sih,et al.  Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain. , 1966, The Journal of biological chemistry.

[52]  J. Slater,et al.  Urinary excretion of 17-ketosteroids following rectal infusion of cortisol. , 1959, The Journal of clinical endocrinology and metabolism.

[53]  J. Nabarro,et al.  Rectal Hydrocortisone , 1957, British medical journal.