Cefoxitin Continuous Infusion for Lung Infection Caused by the Mycobacterium abscessus Group

The Mycobacterium abscessus group is an increasingly recognized cause of antibiotic-resistant lung infection ([1][1][–][2][3][3]). The efficacy of available antibiotics must be optimized. Continuous infusion of active β-lactam agents has the potential to maximize the time blood antibiotic

[1]  John D. Mitchell,et al.  Clinical and microbiologic outcomes in patients receiving treatment for Mycobacterium abscessus pulmonary disease. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  R. Wallace,,et al.  Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes , 2011 .

[3]  M. Rowland,et al.  Clinical pharmacokinetics and pharmacodynamics , 2011 .

[4]  Mary Ann Blosky,et al.  Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. , 2010, American journal of respiratory and critical care medicine.

[5]  Young Kil Park,et al.  Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients. , 2009, American journal of respiratory and critical care medicine.

[6]  D. Paterson,et al.  A systematic review on clinical benefits of continuous administration of &bgr;-lactam antibiotics* , 2009, Critical care medicine.

[7]  Robert Horsburgh,et al.  An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. , 2007, American journal of respiratory and critical care medicine.

[8]  M. Falagas,et al.  Continuous versus intermittent intravenous administration of antibiotics: a meta-analysis of randomised controlled trials. , 2005, The Lancet. Infectious diseases.

[9]  W. Adams,et al.  Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination , 1989, Antimicrobial Agents and Chemotherapy.

[10]  Malcolm Rowland,et al.  Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications , 1980 .