Osteosarcoma in young children

The clinicopathologic features of osteosarcoma in 12 children younger than 6 years of age treated at The Children's Hospital and Dana‐Farber Cancer Institute, Boston, during a 70‐year time period are presented. Only one of six children treated before 1972 is a long‐term survivor. Four of six children (67%) treated after 1972 are disease‐free with an average follow‐up of 8.8 years. The year 1972 marked the onset of use of effective chemotherapy in osteosarcoma, namely, high‐dose methotrexate and leucovorin rescue. It would appear that the pathologic features and behavior of osteosarcoma in young children is similar to that of osteosarcoma in older children and adolescents. A combination of complete (wide) surgical resection or amputation and aggressive chemotherapy offers the best chance of long‐term survival.

[1]  W. Blattner,et al.  A cancer family syndrome in twenty-four kindreds. , 1988, Cancer research.

[2]  S. Rosenberg.  The Development of New Immunotherapies for the Treatment of Cancer Using Interleukin‐2: A Review , 1988, Annals of surgery.

[3]  W. Blattner,et al.  Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family. , 1987, Science.

[4]  N. Jaffe,et al.  Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's Hospital--study III. , 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  N. Jaffe,et al.  Osteosarcoma in early childhood. , 1982, Pediatrics.

[6]  M. T. Gögüs,et al.  Osteogenic sarcoma of the distal femur in a young child. , 1982, Human pathology.

[7]  D. Dahlin.  Prognostic factors in osteosarcoma. , 1980, International journal of radiation oncology, biology, physics.

[8]  A. Look,et al.  Osteosarcoma, fibrous dysplasia, and a chromosomal abnormality in a 3‐year‐old child , 1980, Cancer.

[9]  C. Pratt,et al.  Osteosarcoma in 2 Very Young Children , 1977, Clinical pediatrics.

[10]  H. Ioachim.  The stromal reaction of tumors: an expression of immune surveillance. , 1976, Journal of the National Cancer Institute.

[11]  P. Scranton,et al.  Prognostic factors in osteosarcoma: A review of 20 years' experience at the university of pittsburgh health center hospitals , 1975 .

[12]  F. Sim,et al.  Osteoblastic osteogenic sarcoma in a 35-month-old girl. Report of a case. , 1975, American journal of clinical pathology.

[13]  F. Taylor,et al.  Investigation of carbohydrate metabolism and somatomedin in osteosarcoma patients , 1975, Journal of surgical oncology.

[14]  R. Marcove,et al.  Chondrosarcoma and altered carbohydrate metabolism. , 1963, The New England journal of medicine.

[15]  H. Spjut,et al.  Osteosarcoma , 1961, Acta radiologica.