Pathology of congenital syphilis in rabbits

We have developed a model for congenital syphilis in the rabbit. This report provides additional information on newborn tissue pathology in animals that were infected in utero. A total of 35 pregnancies were evaluated, each containing 6 to 12 newborns. In the infected group, the mortality was approximately 50%; of the live newborns, half appeared normal and half were hyperreflexic, weak, and runty. Gross pathology in the sickly newborns was quite prevalent and involved enlarged spleens with isolated spots of necrosis; enlarged livers that were overtly congested and hemorrhagic and had numerous granular, white spots; and brains with hemorrhage in the occipital area. Histopathology was apparent in different tissues. Lymphocytes, plasma cells, and vacuolated macrophages were prominent in livers, spleens, brains, and bones. A few actively motile treponemes were visualized by dark-field microscopy within extracts of spleen and within cerebrospinal fluid. Low numbers of treponemes were also demonstrated in sections of brain and liver by using the Warthin-Starry silver stain technique. Blood hematocrits were decreased, and extramedullary hematopoiesis was prominent within spleens and livers; this is consistent with anemia. This rabbit model exhibits many of the same pathologic features commonly found in human congenital syphilis.

[1]  T. Fitzgerald,et al.  Congenital syphilis in newborn rabbits: immune functions and susceptibility to challenge infection at 2 and 5 weeks of age , 1991, Infection and immunity.

[2]  C. Marra,et al.  An experimental model of early central nervous system syphilis. , 1991, The Journal of infectious diseases.

[3]  P. Zenker.  New case definition for congenital syphilis reporting. , 1991, Sexually Transmitted Diseases.

[4]  R. Baughn.  Congenital syphilis: immunologic challenges. , 1989, Pathology and immunopathology research.

[5]  Y. Nakanuma,et al.  NONSYNDROMATIC PAUCITY OF INTRAHEPATIC BILE DUCTS IN CONGENITAL SYPHILIS. A Case Report , 1988, Acta pathologica japonica.

[6]  K. Schulz,et al.  Pregnancy loss, infant death, and suffering: legacy of syphilis and gonorrhoea in Africa. , 1987, Genitourinary medicine.

[7]  S. Hira,et al.  Early Congenital Syphilis: Clinico‐radiologic Features in 202 Patients , 1985, Sexually transmitted diseases.

[8]  T. Fitzgerald.  Experimental congenital syphilis in rabbits. , 1985, Canadian journal of microbiology.

[9]  L. Mascola,et al.  Inadequate treatment of syphilis in pregnancy. , 1984, American journal of obstetrics and gynecology.

[10]  C. Chintu,et al.  Congenital syphilis in Lusaka--II. Incidence at birth and potential risk among hospital deliveries. , 1982, East African medical journal.

[11]  S. Kim,et al.  Hematological aspects of congenital syphilis. , 1976, Yonsei medical journal.

[12]  K. Benirschke,et al.  Fetal syphilis in the first trimester. , 1976, American journal of obstetrics and gynecology.

[13]  K. Tan.  THE RE‐EMERGENCE OF EARLY CONGENITAL SYPHILIS , 1973, Acta paediatrica Scandinavica.

[14]  T. E. Hughes.  Glomerulopathy of congenital syphilis. , 1973, The Journal of pediatrics.

[15]  J. Hodgman,et al.  Congenital syphilis in newborn. , 1973, California medicine.

[16]  W. Harrer,et al.  Hydrops fetalis and congenital syphilis. , 1972, Pediatrics.

[17]  R. Heller,et al.  Congenital syphilis: resurgence of an old problem. , 1971, Pediatrics.

[18]  J. Hardy,et al.  Congenital syphilis in the newborn infant: clinical and pathological observations in recent cases. , 1971, The Johns Hopkins medical journal.

[19]  R. Naeye.  Fetal growth with congenital syphilis: a quantitative study. , 1971, American Journal of Clinical Pathology.

[20]  P. Hardy,et al.  Failure of penicillin in a newborn with congenital syphilis. , 1970, JAMA.

[21]  R. Rosen,et al.  Roentgenographic diagnosis of congenital syphilis in the newborn. , 1970, JAMA.

[22]  F. Saxoni,et al.  CONGENITAL SYPHILIS: A DESCRIPTION OF 18 CASES AND RE-EXAMINATION OF AN OLD BUT EVER-PRESENT DISEASE , 1968 .

[23]  I. Freiman,et al.  Thrombocytopenia and congenital syphilis in South African Bantu infants. , 1966, Archives of disease in childhood.

[24]  A. Silverstein.  Congenital Syphilis and the Timing of Immunogenesis in the Human Fœtus , 1962, Nature.

[25]  H. Maccarini.  [Prenatal syphilis]. , 1955, El Dia medico.

[26]  W. Mikułowski.  [Anemia in congenital syphilis]. , 1951, Pediatria Polska.

[27]  H. A. Tucker,et al.  The Jarisch-Herxheimer reaction in early congenital syphilis; a study of 93 patients treated with penicillin alone. , 1949, American journal of syphilis, gonorrhea, and venereal diseases.

[28]  H. W. Mossman,et al.  The rabbit placenta and the problem of placental transmission , 1926 .