CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function
暂无分享,去创建一个
D. Y. Hwang | J. Hong | Yun-Bae Kim | Jugyeong Song | M. Park | S. Han | K. Oh | JaeRyun Hwang | J. H. Kim | Sang-Yeon Oh | C. J. Hwang | Hyun Ok Seo | N. Y. Yun | Na Young Yun
[1] P. Lewczuk,et al. Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides , 2015, Neurobiology of Disease.
[2] J. Hong,et al. Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cells , 2014, Journal of Neuroinflammation.
[3] J. Hong,et al. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells , 2014, Neuropharmacology.
[4] E. Schröck,et al. Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells , 2013, Brain : a journal of neurology.
[5] H. Augustin,et al. Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization , 2012, The Journal of pathology.
[6] Oskar Hansson,et al. CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease , 2012, PloS one.
[7] V. Vullo,et al. In Vitro Downregulation of Matrix Metalloproteinase-9 in Rat Glial Cells by CCR5 Antagonist Maraviroc: Therapeutic Implication for HIV Brain Infection , 2011, PloS one.
[8] W. Banks,et al. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: Multiplex quantification with path analysis , 2011, Brain, Behavior, and Immunity.
[9] S. Gabriel,et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. , 2010, Cancer cell.
[10] S. Nam,et al. CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function , 2009, Neurobiology of Learning and Memory.
[11] S. Nam,et al. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. , 2009, Experimental cell research.
[12] L. J. Eldik,et al. Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes , 2009, Brain Research.
[13] H. Xiong,et al. CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction , 2009, PloS one.
[14] G. Halliday,et al. Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease , 2009, Brain pathology.
[15] John Grist,et al. CCL2 is a key mediator of microglia activation in neuropathic pain states , 2009, European journal of pain.
[16] K. Wada,et al. G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity , 2008, The Journal of Neuroscience.
[17] Lawrence Steinman,et al. Nuanced roles of cytokines in three major human brain disorders. , 2008, The Journal of clinical investigation.
[18] M. Mack,et al. Role of astrocytes and chemokine systems in acute TNFα induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-κB and Akt , 2008, Molecular and Cellular Neuroscience.
[19] Y. Jeon,et al. Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and hindpaw after adjuvant injection , 2008, Neuroreport.
[20] Hosung Jung,et al. Monocyte chemoattractant protein‐1 functions as a neuromodulator in dorsal root ganglia neurons , 2007, Journal of neurochemistry.
[21] A. Proudfoot,et al. CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats , 2007, Brain Research.
[22] M. Kaul,et al. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection , 2007, Cell Death and Differentiation.
[23] M. Ohno,et al. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.
[24] N. Greig,et al. Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide , 2006, Journal of Pharmacology and Experimental Therapeutics.
[25] B. Teferedegne,et al. Mechanism of Action of a Distal NF-κB-Dependent Enhancer , 2006, Molecular and Cellular Biology.
[26] Y. Koninck,et al. Spatial and temporal relationship between monocyte chemoattractant protein‐1 expression and spinal glial activation following peripheral nerve injury , 2006, Journal of neurochemistry.
[27] J. Julien,et al. Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.
[28] M. Schultzberg,et al. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice , 2005, Journal of Neuroimmunology.
[29] A. Stalder,et al. Invasion of Hematopoietic Cells into the Brain of Amyloid Precursor Protein Transgenic Mice , 2005, The Journal of Neuroscience.
[30] H. Katus,et al. Critical Role for Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α in Induction of Experimental Autoimmune Myocarditis and Effective Anti–Monocyte Chemoattractant Protein-1 Gene Therapy , 2005, Circulation.
[31] W. Rostène,et al. Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: Functional effect of MCP‐1/CCL2 on calcium mobilization in primary cultured neurons , 2005, The Journal of comparative neurology.
[32] R. LaMotte,et al. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[33] R. Keep,et al. Monocyte Chemoattractant Protein-1 Regulation of Blood–Brain Barrier Permeability , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[34] James L. Buescher,et al. Overexpression of monocyte chemotactic protein-1/ CCL2 in β-amyloid precursor protein transgenic mice show accelerated diffuse β-amyloid deposition , 2005 .
[35] N. Sparkman,et al. Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice , 2005, Behavioural Brain Research.
[36] S. Roßner,et al. Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme , 2005 .
[37] T. Nakagawa,et al. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain , 2004, Neuroscience Research.
[38] B. Winblad,et al. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid‐induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3 , 2003, Journal of neurochemistry.
[39] M. D'Andrea,et al. Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains , 2003, Brain Research.
[40] P. Scheltens,et al. Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients , 2003, Annals of neurology.
[41] B. Brew,et al. Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation , 2003 .
[42] J. Pachter,et al. Functional expression of CCR2 by human fetal astrocytes , 2002, Journal of neuroscience research.
[43] S. Romagnani. Cytokines and chemoattractants in allergic inflammation. , 2002, Molecular immunology.
[44] W. Rostène,et al. Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain , 2002, Journal of neurochemistry.
[45] S. O’Mara,et al. Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus , 2001, Behavioural Brain Research.
[46] R. Bonavia,et al. Chemokines and Their Receptors in the Central Nervous System , 2001, Frontiers in Neuroendocrinology.
[47] D. Selkoe. Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.
[48] M. Kavaliers,et al. Locomotor activity changes following lipopolysaccharide treatment in mice: a multivariate assessment of behavioral tolerance , 2001, Physiology & Behavior.
[49] F. Annunziato,et al. Expression of the Chemokine Receptor CCR3 on Human Mast Cells , 2001, International Archives of Allergy and Immunology.
[50] M. Dorf,et al. Astrocytes express functional chemokine receptors , 2000, Journal of Neuroimmunology.
[51] R. Doms,et al. Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons , 2000, Neuroscience.
[52] Y. Wang,et al. Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent. , 2000, Kidney international.
[53] D. Davies,et al. β-Amyloid Immunoreactivity in Astrocytes in Alzheimer's Disease Brain Biopsies: An Electron Microscope Study , 1999, Experimental Neurology.
[54] S. Scheff,et al. Synaptic density in the inner molecular layer of the hippocampal dentate gyrus in Alzheimer disease. , 1998, Journal of neuropathology and experimental neurology.
[55] O. Spleiss,et al. Molecular biology of microglia cytokine and chemokine receptors and microglial activation. , 1998, Life sciences.
[56] A. Sauter,et al. Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration , 1997, Journal of Neuroimmunology.
[57] D. Dickson,et al. The Pathogenesis of Senile Plaques , 1997, Journal of neuropathology and experimental neurology.
[58] Y. Misumi,et al. Expression and distribution of CC chemokine macrophage inflammatory protein‐1α/LD78 in the human brain , 1997, Neuroreport.
[59] A. LeBlanc,et al. Processing of Amyloid Precursor Protein in Human Primary Neuron and Astrocyte Cultures , 1997, Journal of neurochemistry.
[60] Brian J Cummings,et al. β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease , 1996, Neurobiology of Aging.
[61] R. Skinner,et al. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis , 1996, Neurobiology of Aging.
[62] R. Ransohoff,et al. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. , 1996, Journal of immunology.
[63] A. Mantovani,et al. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. , 1994, Journal of immunology.
[64] P. Matsudaira,et al. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[65] W. Griffin,et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[66] B. Teferedegne,et al. Mechanism of action of a distal NF-kappaB-dependent enhancer. , 2006, Molecular and cellular biology.
[67] James L. Buescher,et al. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. , 2005, The American journal of pathology.
[68] Bryan Maloney,et al. Gene structure and organization of the human beta-secretase (BACE) promoter. , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[69] B. Brew,et al. Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. , 2003, Glia.
[70] T. Arendt. Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease. , 2002, Journal of neural transmission. Supplementum.
[71] B T Hyman,et al. Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. , 1999, Journal of neurovirology.
[72] D. Davies,et al. beta-Amyloid immunoreactivity in astrocytes in Alzheimer's disease brain biopsies: an electron microscope study. , 1999, Experimental neurology.