Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt.

Recent studies have suggested that the central nervous system is responsible for activation of sympathetic nerve activity (SNA) and the renin-angiotensin system in heart failure (HF). The aim of this study was to determine whether activation of the renin-angiotensin system within the nucleus of the solitary tract (NTS) plays a role in enhanced SNA in HF. High-output HF was induced by an aortocaval (A-V) shunt with some modifications in the rat. These rats exhibited a left ventricular dilatation and hemodynamic signs of high-output HF. Urinary catecholamine excretion and maximal renal SNA (RSNA) were greater in the A-V shunted rats than in the control rats. Microinjection of an angiotensin II type 1-receptor antagonist, CV11974, into the NTS was performed. The arterial pressure and RSNA were reduced by CV11974 to a greater degree in the A-V shunted rats than in the control rats. The expression of angiotensin-converting enzyme mRNA in the medulla was greater in the A-V shunted rats than in the control rats. These results suggest that activation of the renin-angiotensin system within the NTS contributes to an enhanced SNA in this model.

[1]  A. Takeshita,et al.  Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition. , 2000, Hypertension.

[2]  Hirano Shuji,et al.  Differential responses of circulating and tissue adrenomedullin and gene expression to volume overload. , 2000 .

[3]  Y. Koiwaya,et al.  Differential responses of circulating and tissue adrenomedullin and gene expression to volume overload. , 2000, Journal of cardiac failure.

[4]  T. Lohmeier,et al.  Influence of angiotensin on the early progression of heart failure. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[5]  F. Leenen,et al.  Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction. , 1999, American journal of physiology. Heart and circulatory physiology.

[6]  F. Leenen,et al.  Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction. , 1999, The American journal of physiology.

[7]  I. Zucker,et al.  Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II. , 1999, Circulation research.

[8]  F. Leenen,et al.  Pattern of neuronal activation in rats with CHF after myocardial infarction. , 1998, American journal of physiology. Heart and circulatory physiology.

[9]  R. Ruffolo,et al.  Effects of eprosartan on renal function and cardiac hypertrophy in rats with experimental heart failure. , 1998, Hypertension.

[10]  J. Zhuo,et al.  Angiotensin receptors in the nervous system , 1998, Brain Research Bulletin.

[11]  K. Patel,et al.  Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[12]  K. Patel,et al.  Altered number of diaphorase (NOS) positive neurons in the hypothalamus of rats with heart failure , 1998, Brain Research.

[13]  A. Mark,et al.  The treatment of heart failure: the role of neurohumoral activation. , 1998, Internal medicine.

[14]  D. Averill,et al.  Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex. , 1998, The American journal of physiology.

[15]  A. Haramati,et al.  Impaired nitric oxide-mediated renal vasodilation in rats with experimental heart failure: role of angiotensin II. , 1997, Circulation.

[16]  I. Zucker,et al.  Angiotensin II Enhances Baroreflex Control of Sympathetic Outflow in Heart Failure , 1997 .

[17]  Y. Hirooka,et al.  Pressor and sympathoexcitatory effects of nitric oxide in the rostral ventrolateral medulla , 1996, Journal of hypertension.

[18]  I. Zucker,et al.  Hemodynamic and norepinephrine responses to pacing-induced heart failure in conscious sinoaortic-denervated dogs. , 1996, Journal of applied physiology.

[19]  I. Zucker,et al.  Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure , 1996, Brain Research.

[20]  I. Zucker,et al.  Blockade of AT1 receptors enhances baroreflex control of heart rate in conscious rabbits with heart failure. , 1996, The American journal of physiology.

[21]  A. Takeshita,et al.  Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. , 1995, Hypertension.

[22]  G. Dibona,et al.  ANG II receptor blockade and arterial baroreflex regulation of renal nerve activity in cardiac failure. , 1995, The American journal of physiology.

[23]  C. Sernia,et al.  Immunocytochemical localization of angiotensinogen in the fetal and neonatal rat brain , 1995, Neuroscience.

[24]  K. Patel,et al.  Neural regulation of sympathetic nerve activity in heart failure. , 1995, Progress in cardiovascular diseases.

[25]  A L Mark,et al.  Sympathetic dysregulation in heart failure: Mechanisms and therapy , 1995, Clinical cardiology.

[26]  R. Hester,et al.  Evaluation of the needle technique for producing an arteriovenous fistula. , 1994, Journal of applied physiology.

[27]  D. Averill,et al.  Mechanisms of angiotensin-induced hypotension and bradycardia in the medial solitary tract nucleus. , 1994, The American journal of physiology.

[28]  R. Dampney,et al.  Functional organization of central pathways regulating the cardiovascular system. , 1994, Physiological reviews.

[29]  J. Wright,et al.  Brain angiotensin receptor subtypes in the control of physiological and behavioral responses , 1994, Neuroscience & Biobehavioral Reviews.

[30]  T. Hedner,et al.  Characteristics of renal sympathetic nerve activity in experimental congestive heart failure in the rat. , 1994, Acta physiologica Scandinavica.

[31]  R. Kerber,et al.  Effects of beta-blockade on neurohumoral responses and neurochemical markers in pacing-induced heart failure. , 1994, The American journal of physiology.

[32]  Tom E. C. Smith,et al.  Reconceptualizing Support Systems for Persons with Challenging Behaviors , 1994, Psychological reports.

[33]  H. Jacob,et al.  Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. , 1994, Biochemical and biophysical research communications.

[34]  D L Kunze,et al.  Nucleus tractus solitarius--gateway to neural circulatory control. , 1994, Annual review of physiology.

[35]  C. Ferrario,et al.  Receptor subtype that mediates the neuronal effects of angiotensin ii in the rat dorsal medulla , 1993, Brain Research Bulletin.

[36]  J. Bains,et al.  Functional evidence that the angiotensin antagonist losartan crosses the blood-brain barrier in the rat , 1993, Brain Research Bulletin.

[37]  A. Krassioukov,et al.  Connections between the pontine reticular formation and rostral ventrolateral medulla. , 1993, The American journal of physiology.

[38]  R. A. Johnson,et al.  Neurohumoral modulators and sodium balance in experimental heart failure. , 1993, The American journal of physiology.

[39]  A. Takeshita,et al.  Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. , 1993, Circulation research.

[40]  J. Harding,et al.  Regulatory role of brain angiotensins in the control of physiological and behavioral responses , 1992, Brain Research Reviews.

[41]  D. Gehlert,et al.  Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain , 1991, Neuroscience.

[42]  L. Mozley,et al.  Expression of angiotensin converting enzyme mRNA in rat brain. , 1991, Brain research. Molecular brain research.

[43]  D. Robertson,et al.  Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. , 1990, The Journal of pharmacology and experimental therapeutics.

[44]  R. Garcia,et al.  Simple, rapid, and effective method of producing aortocaval shunts in the rat. , 1990, Cardiovascular research.

[45]  D. Diz,et al.  Baroreceptor Reflex Modulation by Angiotensin II at the Nucleus Tractus Solitarii , 1988, Hypertension.

[46]  J. Cohn,et al.  Predicting survival for an individual with congestive heart failure using the plasma norepinephrine concentration. , 1987, American heart journal.

[47]  J. Kampine,et al.  Comparison of four methods of averaging nerve activity. , 1986, The American journal of physiology.

[48]  J. Ingelfinger,et al.  Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. , 1986, Hypertension.

[49]  R. Rettig,et al.  Cardiovascular effects of microinjections of angiotensin II into the nucleus tractus solitarii , 1986, Brain Research.

[50]  L. Swanson,et al.  Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. , 1985, Neuroendocrinology.

[51]  M. Phillips,et al.  Mechanism of pressor effects by angiotensin in the nucleus tractus solitarius of rats. , 1984, The American journal of physiology.

[52]  C. Ferrario,et al.  Altered neural control of cardiovascular function in sodium-depleted dogs , 1982 .

[53]  J. Saavedra,et al.  Distribution of Angiotensin‐Converting Enzyme Activity in Specific Areas of the Rat Brain Stem , 1982, Journal of neurochemistry.

[54]  S. Nellis,et al.  Chronic arteriovenous shunt: evaluation of a model for heart failure in rat. , 1979, The American journal of physiology.