Piezoelectric tactile sensor for submucosal tumor detection in endoscopy

Abstract In this study, we have fabricated a miniaturized piezoelectric tactile sensor (O = 1.4 mm) that is suitable for mounting on an endoscope to detect submucosal tumors. The sensing mechanism is based on a tandem spring model and consists of two components with varying stiffness, namely a hard inner structure embedded in a soft outer packaging. The voltage output of the PVDF sensing film is proportional to the localized normal stress exerted by each component and this differential output can be used to extract information about the elasticity of the test object/biological tissue. The sensor design has been tested by embedding different elastomers and artificial tumors in a pig’s stomach for simulating the conditions of submucosal tumors in humans and shows good agreement with theoretical analysis and numerical simulations. The sensor response is proportional to the Young’s modulus of test sample over a range of 1.01–3.51 MPa, making it suitable for detection of tumors present in soft tissues. The proposed miniaturized tactile sensor utilizes a passive sensing element, is wired to the external readout system through the metal catheter which can be inserted into the endoscopic channel, is safe for insertion into the stomach as it has a biocompatible packaging and can thus be utilized to provide tactile information during regular endoscopy.

[1]  Mitsuhiro Shikida,et al.  Active tactile sensor for detecting contact force and hardness of an object , 2003 .

[2]  Shenshen Zhao,et al.  Design and Modeling of a Wide Dynamic-Range Hardness Sensor for Biological Tissue Assessment , 2013, IEEE Sensors Journal.

[3]  Mark Lee,et al.  Review Article Tactile sensing for mechatronics—a state of the art survey , 1999 .

[4]  A. Walch,et al.  Histopathological classification of nonneoplastic and neoplastic gastrointestinal submucosal lesions. , 2005, Endoscopy.

[5]  Kaspar Althoefer,et al.  Finite-Element Modeling of Soft Tissue Rolling Indentation , 2011, IEEE Transactions on Biomedical Engineering.

[6]  A. Chak EUS in submucosal tumors. , 2002, Gastrointestinal endoscopy.

[7]  A. Erdman,et al.  Flexible Tactile Sensor for Tissue Elasticity Measurements , 2009, Journal of Microelectromechanical Systems.

[8]  S. Rossi,et al.  Endosonographic diagnosis of submucosal upper gastrointestinal tract lesions and large fold gastropathies by catheter ultrasound probe. , 1999, Gastrointestinal Endoscopy.

[9]  Paolo Dario,et al.  Tactile sensing: Technology and applications , 1991 .

[10]  Toshiyuki Tsuchiya,et al.  Micromachined Tactile Sensor for Soft-Tissue Compliance Detection , 2012 .

[11]  L. You,et al.  Universal Ferroelectric Switching Dynamics of Vinylidene Fluoride-trifluoroethylene Copolymer Films , 2014, Scientific Reports.

[12]  Sadao Omata,et al.  New tactile sensor like the human hand and its applications , 1992 .

[13]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[14]  L. Filik,et al.  Accuracy of endoscopic ultrasonography in upper gastrointestinal submucosal lesions. , 2004, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.

[15]  Gi-Hun Yang,et al.  Enhanced tactile sensor for the minimally invasive robotic palpation , 2014, 2014 IEEE/ASME International Conference on Advanced Intelligent Mechatronics.

[16]  Eun Kyung Lee,et al.  Porous PVDF as effective sonic wave driven nanogenerators. , 2011, Nano letters.

[17]  Siamak Najarian,et al.  Tactile Sensor for Robotic Applications , 2009 .

[18]  S. Sokhanvar,et al.  MEMS Endoscopic Tactile Sensor: Toward In-Situ and In-Vivo Tissue Softness Characterization , 2009, IEEE Sensors Journal.

[19]  Yoshihiro Tanaka,et al.  Development of a sensor system with syringe based on tactile sensing using balloon expansion , 2010, 2010 IEEE International Conference on Robotics and Automation.

[20]  Toshiyuki Tsuchiya,et al.  Design and Simulation of a Tactile Sensor for Soft-Tissue Compliance Detection , 2008 .

[21]  Britt M. Andersson,et al.  Detection of stiff nodules embedded in soft tissue phantoms, mimicking cancer tumours, using a tactile resonance sensor , 2014 .

[22]  Anurat Wisitsoraat,et al.  Low cost thin film based piezoresistive MEMS tactile sensor , 2007 .

[23]  R. Reuben,et al.  Measurement of tissue mechanical characteristics to distinguish between benign and malignant prostatic disease. , 2005, Urology.

[24]  D. Rubens,et al.  Tissue elasticity properties as biomarkers for prostate cancer. , 2008, Cancer biomarkers : section A of Disease markers.