UHMK1 is a novel splicing regulatory kinase

[1]  Jared L. Johnson,et al.  An atlas of substrate specificities for the human serine/threonine kinome , 2023, Nature.

[2]  I. Herr,et al.  UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis , 2022, Frontiers in Oncology.

[3]  Lucas E. Wange,et al.  Prime-seq, efficient and powerful bulk RNA sequencing , 2021, bioRxiv.

[4]  Jing Huang,et al.  UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells , 2021, Cell communication and signaling : CCS.

[5]  V. Valente,et al.  PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response. , 2021, Biochimica et biophysica acta. Molecular basis of disease.

[6]  R. F. Luco,et al.  Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition , 2021, Nature Communications.

[7]  Kwang-Huei Lin,et al.  COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma , 2020, Cancers.

[8]  Shona Murphy,et al.  Transcription and splicing: A two‐way street , 2020, Wiley interdisciplinary reviews. RNA.

[9]  Zhiyong Zhang,et al.  UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism , 2020, The EMBO journal.

[10]  Xiuling Zhi,et al.  SPTBN1 and cancer, which links? , 2020, Journal of cellular physiology.

[11]  R. Rabadán,et al.  Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1. , 2019, Molecular cell.

[12]  A. Karginov,et al.  Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. , 2019, Cell chemical biology.

[13]  W. Blalock,et al.  Signal Transduction in Ribosome Biogenesis: A Recipe to Avoid Disaster , 2019, International journal of molecular sciences.

[14]  S. Carr,et al.  TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach* , 2019, Molecular & Cellular Proteomics.

[15]  Shuofeng Hu,et al.  Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells. , 2019, Biochemical and biophysical research communications.

[16]  P. Schirmacher,et al.  YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells , 2019, Oncogene.

[17]  N. Bogdanova,et al.  Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling , 2019, Clinical and translational radiation oncology.

[18]  Damian Szklarczyk,et al.  STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..

[19]  The UniProt Consortium,et al.  UniProt: a worldwide hub of protein knowledge , 2018, Nucleic Acids Res..

[20]  M. Graille,et al.  mRNA decapping: finding the right structures , 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

[21]  G. Tortora,et al.  Abstract 973: MEKK3 sustains EMT and stemness in pancreatic cancer by regulating YAP and TAZ transcriptional activity , 2018, Molecular and Cellular Biology / Genetics.

[22]  B. Kuster,et al.  Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics * , 2018, Molecular & Cellular Proteomics.

[23]  Lorenzo Manti,et al.  The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export , 2017, Nucleic acids research.

[24]  B. Blencowe,et al.  An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms , 2017, Genome research.

[25]  Anton J. Enright,et al.  The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence , 2017, Molecular cell.

[26]  S. T. Olalla Saad,et al.  The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation , 2017, bioRxiv.

[27]  Christoph Ziegenhain,et al.  zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs , 2017, bioRxiv.

[28]  Giuseppe Troiano,et al.  The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) , 2017, International journal of molecular medicine.

[29]  Robert J. Weatheritt,et al.  Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors. , 2017, Molecular cell.

[30]  A. Maucuer,et al.  SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3'-Splice-Site RNA. , 2016, Biophysical journal.

[31]  C. Kielkopf,et al.  Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise , 2016, RNA.

[32]  Jüergen Cox,et al.  The MaxQuant computational platform for mass spectrometry-based shotgun proteomics , 2016, Nature Protocols.

[33]  Hui Shen,et al.  Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene. , 2016, Bone.

[34]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[35]  M. Yashiro,et al.  Lysyl oxidase is associated with the epithelial–mesenchymal transition of gastric cancer cells in hypoxia , 2016, Gastric Cancer.

[36]  K. Shokat,et al.  SR protein kinases promote splicing of nonconsensus introns , 2015, Nature Structural &Molecular Biology.

[37]  Michael A. Freitas,et al.  The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing , 2015, Nucleic acids research.

[38]  Y. Gusev,et al.  βII‐Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin , 2015, Hepatology.

[39]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[40]  H. Scott,et al.  Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy , 2015, Immunological reviews.

[41]  Robert J. Weatheritt,et al.  A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains , 2014, Cell.

[42]  Bin Zhang,et al.  PhosphoSitePlus, 2014: mutations, PTMs and recalibrations , 2014, Nucleic Acids Res..

[43]  M. Aldea,et al.  KIS, a Kinase Associated with Microtubule Regulators, Enhances Translation of AMPA Receptors and Stimulates Dendritic Spine Remodeling , 2014, The Journal of Neuroscience.

[44]  L. Hugendubler,et al.  The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing , 2014, Journal of Lipid Research.

[45]  Justin Andrew Powell,et al.  GO2MSIG, an automated GO based multi-species gene set generator for gene set enrichment analysis , 2014, BMC Bioinformatics.

[46]  W. Heyer,et al.  Rad54 functions as a heteroduplex DNA pump modulated by its DNA substrates and Rad51 during D loop formation. , 2014, Molecular cell.

[47]  M. Chou,et al.  pLogo: a probabilistic approach to visualizing sequence motifs , 2013, Nature Methods.

[48]  C. Sette,et al.  Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer , 2013, International journal of cell biology.

[49]  J. Chen,et al.  MEMO1, a new IRS1-interacting protein, induces epithelial–mesenchymal transition in mammary epithelial cells , 2013, Oncogene.

[50]  S. Bohlander,et al.  The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS). , 2013, Biochimica et biophysica acta.

[51]  Benjamin J. Blencowe,et al.  Dynamic Integration of Splicing within Gene Regulatory Pathways , 2013, Cell.

[52]  M. Alló,et al.  Alternative splicing: a pivotal step between eukaryotic transcription and translation , 2013, Nature Reviews Molecular Cell Biology.

[53]  Michael R. Green,et al.  Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex. , 2013, Structure.

[54]  M. Nieto,et al.  Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. , 2012, Cancer cell.

[55]  Ivan Cvitkovic,et al.  Spliceosome Database: a tool for tracking components of the spliceosome , 2012, Nucleic Acids Res..

[56]  E. Kremmer,et al.  The Protein Kinase KIS Impacts Gene Expression during Development and Fear Conditioning in Adult Mice , 2012, PloS one.

[57]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[58]  Stephen R. Bond,et al.  RF-Cloning.org: an online tool for the design of restriction-free cloning projects , 2012, Nucleic Acids Res..

[59]  E. Azzam,et al.  Role of the translationally controlled tumor protein in DNA damage sensing and repair , 2012, Proceedings of the National Academy of Sciences.

[60]  Luis G. Morello,et al.  The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing , 2011, PloS one.

[61]  Joerg E Braun,et al.  GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. , 2011, Molecular cell.

[62]  Angela L. Morrison,et al.  Nucleophosmin deposition during mRNA 3′ end processing influences poly(A) tail length , 2011, The EMBO journal.

[63]  Maria Carmo-Fonseca,et al.  Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36 , 2011, Nature Structural &Molecular Biology.

[64]  K. Tomizawa,et al.  Transformation of eEF1Bδ into heat‐shock response transcription factor by alternative splicing , 2011, EMBO reports.

[65]  D. Klein,et al.  Selective Genomic Targeting by FRA-2/FOSL2 Transcription Factor , 2011, The Journal of Biological Chemistry.

[66]  Patrick G. A. Pedrioli,et al.  Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast , 2010, Science Signaling.

[67]  Kristen M. Deleault,et al.  CARHSP1 Is Required for Effective Tumor Necrosis Factor Alpha mRNA Stabilization and Localizes to Processing Bodies and Exosomes , 2010, Molecular and Cellular Biology.

[68]  M. Zavolan,et al.  Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing , 2010, Nucleic acids research.

[69]  M. Lindström.  NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling , 2010, Biochemistry research international.

[70]  R. Mains,et al.  Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. , 2010, Molecular endocrinology.

[71]  W. Tarn,et al.  TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation , 2010, Nucleic acids research.

[72]  Davis J. McCarthy,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[73]  R. Vaillancourt,et al.  MEKK3 Initiates Transforming Growth Factor &bgr;2–Dependent Epithelial-to-Mesenchymal Transition During Endocardial Cushion Morphogenesis , 2008, Circulation research.

[74]  E. Nabel,et al.  KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. , 2008, The Journal of clinical investigation.

[75]  E. Garí,et al.  Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation , 2008, Molecular and Cellular Biology.

[76]  V. Manceau,et al.  Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. , 2008, Journal of molecular biology.

[77]  Stefan Stamm,et al.  Regulation of Alternative Splicing by Reversible Protein Phosphorylation* , 2008, Journal of Biological Chemistry.

[78]  M. Mann,et al.  PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites , 2007, Genome Biology.

[79]  F. Katzen.  Gateway® recombinational cloning: a biological operating system , 2007, Expert opinion on drug discovery.

[80]  Wolf-Dietrich Heyer,et al.  Rad54: the Swiss Army knife of homologous recombination? , 2006, Nucleic acids research.

[81]  Amos Bairoch,et al.  ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins , 2006, Nucleic Acids Res..

[82]  J. L. Le Caer,et al.  Major phosphorylation of SF1 on adjacent Ser‐Pro motifs enhances interaction with U2AF65 , 2006, The FEBS journal.

[83]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[84]  A. Krämer,et al.  Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo. , 2005, Molecular biology of the cell.

[85]  Michael R. Green,et al.  U2AF homology motifs: protein recognition in the RRM world. , 2004, Genes & development.

[86]  I. Eperon,et al.  A double reporter assay for detecting changes in the ratio of spliced and unspliced mRNA in mammalian cells. , 2002, Nucleic acids research.

[87]  E. Nabel,et al.  A growth factor‐dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression , 2002, The EMBO journal.

[88]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[89]  R. Mains,et al.  Signaling Mediated by the Cytosolic Domain of Peptidylglycine α-Amidating Monooxygenase , 2001 .

[90]  Z. Strezoska,et al.  Bop1 Is a Mouse WD40 Repeat Nucleolar Protein Involved in 28S and 5.8S rRNA Processing and 60S Ribosome Biogenesis , 2000, Molecular and Cellular Biology.

[91]  J. L. Le Caer,et al.  Specific Ser-Pro phosphorylation by the RNA-recognition motif containing kinase KIS. , 2000, European journal of biochemistry.

[92]  R. Mains,et al.  The Novel Kinase Peptidylglycine α-Amidating Monooxygenase Cytosolic Interactor Protein 2 Interacts with the Cytosolic Routing Determinants of the Peptide Processing Enzyme Peptidylglycine α-Amidating Monooxygenase* , 1999, The Journal of Biological Chemistry.

[93]  S. Baserga,et al.  M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. , 1998, Molecular biology of the cell.

[94]  O. Gavet,et al.  KIS Is a Protein Kinase with an RNA Recognition Motif* , 1997, The Journal of Biological Chemistry.

[95]  M. Rosbash,et al.  The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC , 1997, Cell.

[96]  R. C. Johnson,et al.  Novel Proteins That Interact with the COOH-terminal Cytosolic Routing Determinants of an Integral Membrane Peptide-processing Enzyme* , 1996, The Journal of Biological Chemistry.

[97]  R. Naviaux,et al.  The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses , 1996, Journal of virology.

[98]  J. Camonis,et al.  Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[99]  B. Kuster,et al.  High pH Reversed-Phase Micro-Columns for Simple, Sensitive, and Efficient Fractionation of Proteome and (TMT labeled) Phosphoproteome Digests. , 2017, Methods in molecular biology.

[100]  Heiner Koch,et al.  Optimized Enrichment of Phosphoproteomes by Fe-IMAC Column Chromatography. , 2017, Methods in molecular biology.

[101]  Fabian Sievers,et al.  Clustal Omega, accurate alignment of very large numbers of sequences. , 2014, Methods in molecular biology.

[102]  Z. Fu,et al.  PRRX1 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer , 2014, Medical Oncology.

[103]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[104]  H. Lodish,et al.  differentiation progenitor cells and is required for epo regulation of erythroid cell AKT induces erythroid cell maturation of JAK2-deficient fetal liver , 2013 .

[105]  Christine Unger,et al.  In vitro cell migration and invasion assays. , 2013, Mutation research.

[106]  R. C. Johnson,et al.  Signaling mediated by the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. , 2001, Molecular biology of the cell.

[107]  Thomas D. Schmittgen,et al.  Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method , 2022 .