Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
暂无分享,去创建一个
[1] Amanda Doucette,et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer , 2009, Nature.
[2] Patrick G. A. Pedrioli,et al. Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA , 2009, Nature.
[3] M. Roussel,et al. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. , 2009, Molecular cell.
[4] H. Ploegh,et al. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway , 2008, Proceedings of the National Academy of Sciences.
[5] S. Gygi,et al. Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis , 2008, Science.
[6] H. Hayashi,et al. Thio-modification of Yeast Cytosolic tRNA Requires a Ubiquitin-related System That Resembles Bacterial Sulfur Transfer Systems* , 2008, Journal of Biological Chemistry.
[7] Anjanabha Saha,et al. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation , 2008, Molecular cell.
[8] A. Byström,et al. A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. , 2008, RNA.
[9] M. Peter,et al. Function and regulation of protein neddylation , 2008, EMBO reports.
[10] V. Schreiber,et al. The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series , 2008, EMBO reports.
[11] Daniel C. Scott,et al. Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation , 2008, Cell.
[12] J. Huibregtse,et al. The Basis for Selective E1-E2 Interactions in the ISG15 Conjugation System* , 2008, Journal of Biological Chemistry.
[13] R. Osman,et al. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail , 2008, Proceedings of the National Academy of Sciences.
[14] Hermann Schindelin,et al. Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes , 2008, Cell.
[15] M. Roussel,et al. Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1 , 2008, Biochemistry.
[16] Harold E. Smith,et al. E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development , 2008, PLoS genetics.
[17] Ivan Dikic,et al. Atypical ubiquitin chains: new molecular signals , 2008, EMBO reports.
[18] H. Schindelin,et al. The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. , 2008, Biochemistry.
[19] D. Willis. A decade on , 2008, Journal of intellectual disabilities : JOID.
[20] Michael M. Madden,et al. Substrate properties of ubiquitin carboxyl-terminally derived peptide probes for protein ubiquitination. , 2008, Biochemistry.
[21] C. Walsh,et al. Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7. , 2008, Journal of the American Chemical Society.
[22] B. Schulman,et al. Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2 , 2008, Nature Structural &Molecular Biology.
[23] Ji Luo,et al. Cancer Proliferation Gene Discovery Through Functional Genomics , 2008, Science.
[24] E. Hoffman,et al. Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy. , 2008, American journal of human genetics.
[25] A. Bergmann,et al. The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously , 2007, Development.
[26] F. Melchior,et al. Concepts in sumoylation: a decade on , 2007, Nature Reviews Molecular Cell Biology.
[27] T. Mizushima,et al. Crystal structure of Ufc1, the Ufm1-conjugating enzyme. , 2007, Biochemical and biophysical research communications.
[28] Dean P. Jones,et al. Commensal bacteria modulate cullin‐dependent signaling via generation of reactive oxygen species , 2007, The EMBO journal.
[29] Yili Yang,et al. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. , 2007, Cancer research.
[30] Zhijian J. Chen,et al. E1-L2 activates both ubiquitin and FAT10. , 2007, Molecular cell.
[31] R. Singh,et al. UBE1L2, a Novel E1 Enzyme Specific for Ubiquitin*♦ , 2007, Journal of Biological Chemistry.
[32] Weidong Hu,et al. The intrinsic affinity between E2 and the Cys domain of E1 in ubiquitin-like modifications. , 2007, Molecular cell.
[33] Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins. , 2007, Molecular cell.
[34] S. Gygi,et al. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging , 2007, Nature.
[35] S. Chiocca,et al. Targeting SUMO E1 to Ubiquitin Ligases , 2007, Journal of Biological Chemistry.
[36] R. Deshaies,et al. A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome. , 2007, Molecular biology of the cell.
[37] F. Inagaki,et al. The Crystal Structure of Atg3, an Autophagy-related Ubiquitin Carrier Protein (E2) Enzyme that Mediates Atg8 Lipidation* , 2007, Journal of Biological Chemistry.
[38] I. Hariharan,et al. Mutation of the Gene Encoding the Ubiquitin Activating Enzyme Uba1 Causes Tissue Overgrowth in Drosophila , 2007, Fly.
[39] A. Goldberg. Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. , 2007, Biochemical Society transactions.
[40] J. Holton,et al. Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity , 2007, Nature.
[41] S. Chiocca,et al. TARGETING SUMO E1 TO UBIQUITIN LIGASES: A VIRAL STRATEGY TO COUNTERACT SUMOYLATION , 2007 .
[42] P. Hanawalt,et al. Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme , 2006, Proceedings of the National Academy of Sciences.
[43] M. Hochstrasser,et al. Modification of proteins by ubiquitin and ubiquitin-like proteins. , 2006, Annual review of cell and developmental biology.
[44] A. Haas,et al. Pleiotropic Effects of ATP·Mg2+ Binding in the Catalytic Cycle of Ubiquitin-activating Enzyme* , 2006, Journal of Biological Chemistry.
[45] J. Wade Harper,et al. Structural Complexity in Ubiquitin Recognition , 2006, Cell.
[46] F. Melchior,et al. Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. , 2006, Molecular cell.
[47] M. Hochstrasser. Lingering Mysteries of Ubiquitin-Chain Assembly , 2006, Cell.
[48] Tadhg P Begley,et al. Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis. , 2006, Biochemistry.
[49] Avram Hershko,et al. The ubiquitin system for protein degradation and some of its roles in the control of the cell-division cycle (Nobel lecture). , 2005, Angewandte Chemie.
[50] A. Ciechanover. Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture). , 2005, Angewandte Chemie.
[51] Brian Kuhlman,et al. E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer , 2005, Nature Structural &Molecular Biology.
[52] Linda Hicke,et al. Ubiquitin-binding domains , 2005, Nature Reviews Molecular Cell Biology.
[53] B. Schulman,et al. Structural analysis of Escherichia coli ThiF. , 2005, Journal of molecular biology.
[54] M. Bochtler,et al. Crystal Structure of a Fragment of Mouse Ubiquitin-activating Enzyme* , 2005, Journal of Biological Chemistry.
[55] David Reverter,et al. Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex , 2005, Nature.
[56] Alexander Varshavsky,et al. Regulated protein degradation. , 2005, Trends in biochemical sciences.
[57] C. Lima,et al. Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 , 2005, The EMBO journal.
[58] J. Holton,et al. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. , 2005, Molecular cell.
[59] Aaron Ciechanover,et al. Proteolysis: from the lysosome to ubiquitin and the proteasome , 2005, Nature Reviews Molecular Cell Biology.
[60] D. Fushman,et al. Polyubiquitin chains: polymeric protein signals. , 2004, Current opinion in chemical biology.
[61] C. Pickart,et al. Ubiquitin: structures, functions, mechanisms. , 2004, Biochimica et biophysica acta.
[62] R. Hay,et al. A mechanism for inhibiting the SUMO pathway. , 2004, Molecular cell.
[63] M. Hochstrasser,et al. Ubiquitin signalling: what's in a chain? , 2004, Nature Cell Biology.
[64] R. Krug,et al. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein , 2004 .
[65] David W. Miller,et al. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 , 2004, Nature Structural &Molecular Biology.
[66] Keiji Tanaka,et al. A novel protein‐conjugating system for Ufm1, a ubiquitin‐fold modifier , 2004, The EMBO journal.
[67] Alejandro Chavez,et al. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[68] B. Schulman,et al. Ubiquitin-like protein activation , 2004, Oncogene.
[69] D. C. Dias,et al. Nedd8 on cullin: building an expressway to protein destruction , 2004, Oncogene.
[70] David W. Miller,et al. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. , 2003, Molecular cell.
[71] G. Sprague,,et al. Attachment of the Ubiquitin-Related Protein Urm1p to the Antioxidant Protein Ahp1p , 2003, Eukaryotic Cell.
[72] M. Tatham,et al. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. , 2003, Biochemistry.
[73] A. Haas,et al. Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer* , 2003, Journal of Biological Chemistry.
[74] B. Schulman,et al. Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 , 2003, Nature.
[75] C. Slaughter,et al. Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation* , 2002, The Journal of Biological Chemistry.
[76] H. Naganawa,et al. Panepophenanthrin, from a mushroom strain, a novel inhibitor of the ubiquitin-activating enzyme. , 2002, Journal of natural products.
[77] H. Schindelin,et al. Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB–MoaD complex , 2001, Nature.
[78] K. Rajagopalan,et al. Characterization of Escherichia coli MoeB and Its Involvement in the Activation of Molybdopterin Synthase for the Biosynthesis of the Molybdenum Cofactor* , 2001, The Journal of Biological Chemistry.
[79] C. Pickart,et al. Distinct Functional Surface Regions on Ubiquitin* , 2001, The Journal of Biological Chemistry.
[80] A. Dautry‐Varsat,et al. Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments. , 2001, Molecular biology of the cell.
[81] M. Komatsu,et al. The C-terminal Region of an Apg7p/Cvt2p Is Required for Homodimerization and Is Essential for Its E1 Activity and E1-E2 Complex Formation* , 2001, The Journal of Biological Chemistry.
[82] R. Krug,et al. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein , 2001, The EMBO journal.
[83] T. Ueno,et al. The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3* , 2001, The Journal of Biological Chemistry.
[84] L. Nicholson,et al. Solution structure of ThiS and implications for the evolutionary roots of ubiquitin , 2001, Nature Structural Biology.
[85] Takeshi Noda,et al. A ubiquitin-like system mediates protein lipidation , 2000, Nature.
[86] M. Hochstrasser,et al. Evolution and function of ubiquitin-like protein-conjugation systems , 2000, Nature Cell Biology.
[87] M. Hochstrasser,et al. A viable ubiquitin‐activating enzyme mutant for evaluating ubiquitin system function in Saccharomyces cerevisiae , 2000, FEBS letters.
[88] E. Yeh,et al. Ubiquitin-like proteins: new wines in new bottles. , 2000, Gene.
[89] R. Neve,et al. The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons* , 2000, The Journal of Biological Chemistry.
[90] Takeshi Noda,et al. A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes* , 2000, The Journal of Biological Chemistry.
[91] N. Mizushima,et al. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. , 1999, Molecular biology of the cell.
[92] E. Yeh,et al. Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway* , 1999, The Journal of Biological Chemistry.
[93] R. Hay,et al. Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1* , 1999, The Journal of Biological Chemistry.
[94] E. Yeh,et al. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin‐activating enzyme complex , 1999, FEBS letters.
[95] C. Hill,et al. Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes* , 1998, The Journal of Biological Chemistry.
[96] Michael D. George,et al. A protein conjugation system essential for autophagy , 1998, Nature.
[97] S. Jentsch,et al. A novel protein modification pathway related to the ubiquitin system , 1998, The EMBO journal.
[98] C. Hill,et al. Crystal Structure of the Saccharomyces cerevisiae Ubiquitin-conjugating Enzyme Rad6 at 2.6 Å Resolution* , 1998, The Journal of Biological Chemistry.
[99] G. Blobel,et al. The ubiquitin‐like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer , 1997, The EMBO journal.
[100] A Perrakis,et al. Crystal Structure of Murine/Human Ubc9 Provides Insight into the Variability of the Ubiquitin-conjugating System* , 1997, The Journal of Biological Chemistry.
[101] A. Ciechanover,et al. The ubiquitin conjugation system is required for ligand‐induced endocytosis and degradation of the growth hormone receptor. , 1996, The EMBO journal.
[102] A. Ciechanover,et al. The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner* , 1996, The Journal of Biological Chemistry.
[103] A. Goffeau,et al. An Essential Yeast Gene Encoding a Homolog of Ubiquitin-activating Enzyme (*) , 1995, The Journal of Biological Chemistry.
[104] A. Ciechanover,et al. Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent. , 1994, The Biochemical journal.
[105] C. Pickart,et al. Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1). , 1994, The Journal of biological chemistry.
[106] H. Weintraub,et al. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1 , 1992, Cell.
[107] M. Sullivan,et al. Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in vitro mutagenesis. , 1991, The Journal of biological chemistry.
[108] S. Jentsch,et al. UBA 1: an essential yeast gene encoding ubiquitin‐activating enzyme. , 1991, The EMBO journal.
[109] A. Ciechanover,et al. Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[110] R. Vierstra,et al. Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli. , 1990, The Journal of biological chemistry.
[111] K. Wilkinson,et al. A specific inhibitor of the ubiquitin activating enzyme: synthesis and characterization of adenosyl-phospho-ubiquitinol, a nonhydrolyzable ubiquitin adenylate analogue. , 1990, Biochemistry.
[112] A. Haas,et al. Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation. , 1988, The Journal of biological chemistry.
[113] A. Haas,et al. The resolution and characterization of putative ubiquitin carrier protein isozymes from rabbit reticulocytes. , 1988, The Journal of biological chemistry.
[114] I. A. Rose,et al. Functional heterogeneity of ubiquitin carrier proteins. , 1985, Progress in clinical and biological research.
[115] A. Ciechanover,et al. Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation. , 1985, Progress in clinical and biological research.
[116] A. Ciechanover,et al. Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85 , 1984, Cell.
[117] I. A. Rose,et al. Ubiquitin adenylate: structure and role in ubiquitin activation. , 1983, Biochemistry.
[118] A. Ciechanover,et al. Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. , 1983, The Journal of biological chemistry.
[119] A. Ciechanover,et al. Components of Ubiquitin-Protein Ligase System , 1983 .
[120] A. Haas,et al. The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. , 1982, The Journal of biological chemistry.
[121] A. Hershko,et al. Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. , 1982, The Journal of biological chemistry.
[122] A. Ciechanover,et al. "Covalent affinity" purification of ubiquitin-activating enzyme. , 1982, The Journal of biological chemistry.
[123] A Ciechanover,et al. Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. , 1981, Proceedings of the National Academy of Sciences of the United States of America.