Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected].

[1]  R. Germain,et al.  Monoclonal antibodies against the antigen receptor on a cloned , 1999 .

[2]  P. Marrack,et al.  Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. , 1998, Immunity.

[3]  Y. Chien,et al.  Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. , 1998, Immunity.

[4]  M. Davis,et al.  Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. McMichael,et al.  A New Look at T Cells , 1998, The Journal of experimental medicine.

[6]  W A Hendrickson,et al.  Crystal structure of I-Ak in complex with a dominant epitope of lysozyme. , 1998, Immunity.

[7]  P. A. Peterson,et al.  Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. , 1998, Immunity.

[8]  L R Pease,et al.  Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. , 1998, Science.

[9]  Mark M. Davis,et al.  LIGAND RECOGNITION BY T CELL RECEPTORS , 1998 .

[10]  Z Reich,et al.  Ligand recognition by alpha beta T cell receptors. , 1998, Annual review of immunology.

[11]  M. Daëron,et al.  Fc receptor biology. , 2003, Annual review of immunology.

[12]  J. Strominger,et al.  Superactivation of an immune response triggered by oligomerized T cell epitopes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  D. Zaller,et al.  X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. , 1997, Immunity.

[14]  Y. Chien,et al.  CD4 augments the response of a T cell to agonist but not to antagonist ligands. , 1997, Immunity.

[15]  Mark M. Davis,et al.  Ligand-specific oligomerization of T-cell receptor molecules , 1997, Nature.

[16]  A. Lanzavecchia,et al.  Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. , 1997, Immunology today.

[17]  Christoph Wülfing,et al.  Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal , 1997, The Journal of experimental medicine.

[18]  B. Goldstein,et al.  Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[19]  M. Reth,et al.  Initiation and processing of signals from the B cell antigen receptor. , 1997, Annual review of immunology.

[20]  R. Perlmutter,et al.  Differential signaling by lymphocyte antigen receptors. , 1997, Annual review of immunology.

[21]  P. A. Peterson,et al.  CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes , 1996, Nature.

[22]  Partho Ghosh,et al.  Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 , 1996, Nature.

[23]  Philip J. R. Goulder,et al.  Phenotypic Analysis of Antigen-Specific T Lymphocytes , 1996, Science.

[24]  M. Davis,et al.  Altered T cell receptor ligands trigger a subset of early T cell signals. , 1996, Immunity.

[25]  Y. Chien,et al.  Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface , 1996, The Journal of experimental medicine.

[26]  Y. Chien,et al.  A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. , 1996, Immunity.

[27]  D. Fremont,et al.  Structures of an MHC Class II Molecule with Covalently Bound Single Peptides , 1996, Science.

[28]  M. Davis,et al.  Kinetic discrimination in T-cell activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Partho Ghosh,et al.  The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3 , 1995, Nature.

[30]  E. Ortega,et al.  How do multichain immune recognition receptors signal? A structural hypothesis. , 1995, Molecular immunology.

[31]  A. Casrouge,et al.  Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness , 1995, The Journal of experimental medicine.

[32]  T. McKeithan,et al.  Kinetic proofreading in T-cell receptor signal transduction. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. Davis,et al.  Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[34]  K. Katz,et al.  Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC , 1994, Nature.

[35]  J. Roberts,et al.  Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains , 1994, The Journal of experimental medicine.

[36]  M. Davis,et al.  Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). , 1994, Journal of immunology.

[37]  K. Karjalainen High sensitivity, low affinity--paradox of T-cell receptor recognition. , 1994, Current opinion in immunology.

[38]  R. Metzger THE CYTOSENSOR™-MICROPHYSIOMETER: BIOLOGICAL APPLICATIONS OF LIVING CELLS ON SILICON SENSOR , 1994 .

[39]  J. Altman,et al.  Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  B. Seed,et al.  T cell activation by clustered tyrosine kinases , 1993, Cell.

[41]  D. Wiley,et al.  Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 , 1993, Nature.

[42]  D. Banner,et al.  Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation , 1993, Cell.

[43]  H. Dintzis,et al.  Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays , 1992, The Journal of experimental medicine.

[44]  J. W. Parce,et al.  The cytosensor microphysiometer: biological applications of silicon technology. , 1992, Science.

[45]  Arthur Weiss,et al.  Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor , 1992, Cell.

[46]  A. Wakeham,et al.  Profound block in thymocyte development in mice lacking p56lck , 1992, Nature.

[47]  S. Buus,et al.  Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas. , 1992, Journal of immunology.

[48]  P. Kavathas,et al.  Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase , 1990, Molecular and cellular biology.

[49]  R. Perlmutter,et al.  Interaction of the unique N-terminal region of tyrosine kinase p56 lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs , 1990, Cell.

[50]  H. Dintzis,et al.  The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence. , 1989, Journal of immunology.

[51]  T. Watts T cell activation by preformed, long-lived Ia-peptide complexes. Quantitative aspects. , 1988, Journal of immunology.

[52]  C. Cantor,et al.  Characterization and crystallization of core streptavidin. , 1987, The Journal of biological chemistry.

[53]  P. Fink,et al.  Correlations between T-cell specificity and the structure of the antigen receptor , 1986, Nature.

[54]  Mark M. Davis,et al.  Variability and repertoire size of T-cell receptor Vα gene segments , 1985, Nature.

[55]  Mark M. Davis,et al.  Somatic recombination in a murine T-cell receptor gene , 1984, Nature.

[56]  R. Germain,et al.  Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[57]  P. Marrack,et al.  The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomas , 1983, Cell.

[58]  E. Reinherz,et al.  Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones , 1983, The Journal of experimental medicine.

[59]  C. Janeway,et al.  Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells , 1983, The Journal of experimental medicine.

[60]  D. Longo,et al.  The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c , 1982, Cell.