Measurement of arterial wall thickness as a surrogate marker for atherosclerosis.

Large observational studies and atherosclerosis regression trials of lipid-modifying pharmacotherapy have established that intima-media thickness of the carotid and femoral arteries, as measured noninvasively by B-mode ultrasound, is a valid surrogate marker for the progression of atherosclerotic disease. To exploit fully the potential of ultrasound imaging in atherosclerosis research, standardized and strictly implemented imaging protocols should be used in both observational studies and applied clinical research. This article describes such a protocol developed at the Academic Medical Center of the University of Amsterdam, the Netherlands. Results are presented from a study that estimated atherosclerosis progression from childhood into old age by measuring intima-media thickness in subjects with familial hypercholesterolemia compared with healthy controls.

[1]  G J Boerma,et al.  Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS). , 1995, Circulation.

[2]  R. Ross.  The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[3]  T. Farag,et al.  Familial hypercholesterolemia. , 1988, Journal of the Royal Society of Medicine.

[4]  R. Prentice.  Surrogate endpoints in clinical trials: definition and operational criteria. , 1989, Statistics in medicine.

[5]  P Pignoli,et al.  Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. A new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. , 1988, Atherosclerosis.

[6]  THEIR UTILITY FOR EVALUATING THERAPEUTIC EFFICACY IN CLINICAL TRIALS , 1998 .

[7]  T. Dawber,et al.  II. Coronary Heart Disease in the Framingham Study , 1957 .

[8]  J. Salonen,et al.  Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. , 1995, Circulation.

[9]  Gerardo Heiss,et al.  Carotid Artery Intimal‐Medial Thickness Distribution in General Populations As Evaluated by B‐Mode Ultrasound , 1993, Stroke.

[10]  M. Trip,et al.  Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia (ASAP): a prospective, randomised, double-blind trial , 2001, The Lancet.

[11]  L. Chambless,et al.  Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. , 1991, American journal of epidemiology.

[12]  Alan D. Lopez,et al.  Mortality by cause for eight regions of the world: Global Burden of Disease Study , 1997, The Lancet.

[13]  Allen J. Taylor,et al.  ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: A Randomized Trial Comparing the Effects of Atorvastatin and Pravastatin on Carotid Intima Medial Thickness , 2002, Circulation.

[14]  A. Folsom,et al.  Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. , 1997, American journal of epidemiology.

[15]  Eary,et al.  CAROTID-ARTERY INTIMA AND MEDIA THICKNESS AS A RISK FACTOR FOR MYOCARDIAL INFARCTION AND STROKE IN OLDER ADULTS , 2000 .

[16]  George Howard,et al.  High‐resolution B‐Mode Ultrasound Scanning Methods in the Atherosclerosis Risk in Communities Study (ARIC) , 1991, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[17]  Arno W. Hoes,et al.  Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. , 1997, Circulation.

[18]  T. Dawber,et al.  Coronary heart disease in the Framingham study. , 1957, American journal of public health and the nation's health.

[19]  J. Collet,et al.  Surrogate endpoints: A basis for a rational approach , 2006, European Journal of Clinical Pharmacology.

[20]  C. Scriver,et al.  The Metabolic and Molecular Bases of Inherited Disease, 8th Edition 2001 , 2001, Journal of Inherited Metabolic Disease.

[21]  Thomas R. Fleming,et al.  Surrogate Endpoints in Clinical Trials , 1996 .

[22]  Elena Tremoli,et al.  Carotid Artery Intima-Media Thickness Measured by Ultrasonography in Normal Clinical Practice Correlates Well With Atherosclerosis Risk Factors , 2000, Stroke.

[23]  J. Wittes,et al.  Surrogate endpoints in clinical trials: cardiovascular diseases. , 1989, Statistics in medicine.

[24]  C. Zarins,et al.  Compensatory enlargement of human atherosclerotic coronary arteries. , 1987, The New England journal of medicine.

[25]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[26]  L. Solberg,et al.  Risk factors and atherosclerotic lesions. A review of autopsy studies. , 1983, Arteriosclerosis.

[27]  H. Hodis,et al.  Arterial imaging and atherosclerosis reversal , 1994 .

[28]  Hennerici ..  Vascular Diagnosis with Ultrasound , 2005 .

[29]  C. Furberg,et al.  Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. , 1994, Circulation.

[30]  C. Parisot.  The DICOM standard , 1995, The International Journal of Cardiac Imaging.

[31]  H. Hodis,et al.  George Lyman Duff Memorial Lecture. Arterial imaging and atherosclerosis reversal. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[32]  London UK Monday 26th February 2001 Speaker and Poster Ab The Royal Society of Medicine.  3rd European Meeting on Pulse Wave Analysis and Large Artery Function , 2001 .

[33]  A. Zwinderman,et al.  B-mode ultrasound assessment of pravastatin treatment effect on carotid and femoral artery walls and its correlations with coronary arteriographic findings: a report of the Regression Growth Evaluation Statin Study (REGRESS). , 1998, Journal of the American College of Cardiology.

[34]  M L Bots,et al.  Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly: The Rotterdam Study , 2002, Circulation.

[35]  L. Kuller.  Epidemiology and Prevention of Cardiovascular Diseases: A Global Challenge , 2002 .

[36]  V. Fuster,et al.  Coronary atherosclerosis : a multifactorial disease , 1993 .

[37]  C. Furberg,et al.  Methodological issues facing studies of atherosclerotic change. , 1993, Circulation.

[38]  J D Thomas,et al.  Digital storage of echocardiograms offers superior image quality to analog storage, even with 20:1 digital compression: results of the Digital Echo Record Access Study. , 1996, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[39]  W. Mack,et al.  Beneficial Effects of Colestipol‐Niacin Therapy on the Common Carotid Artery. Two‐ and Four‐Year Reduction of Intima‐Media Thickness Measured by Ultrasound , 1993, Circulation.