Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes
暂无分享,去创建一个
Young-Bum Kim | Xin Xiao Zheng | Stefan Krauss | Olivier Boss | Thilo Hagen | Catherine B. Chan | B. Lowell | G. Shulman | S. Krauss | P. Perret | O. Boss | X. Zheng | M. Wheeler | Young-Bum Kim | O. Peroni | A. Vidal-Puig | T. Hagen | G. Baffy | Bradford B. Lowell | Gerald I. Shulman | György Baffy | Chen-Yu Zhang | Chen-Yu Zhang | Pascale Perret | Odile Peroni | Danica Grujic | Antonio J. Vidal-Puig | Michael B. Wheeler | D. Grujic
[1] R. Jaenisch,et al. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[2] K. Polonsky,et al. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. , 1998, Diabetes.
[3] R. Unger. Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications , 1995, Diabetes.
[4] J. Miyazaki,et al. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[5] Catherine B. Chan,et al. Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats , 1991, Molecular and Cellular Endocrinology.
[6] S. Kahn. The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus. , 2000, The American journal of medicine.
[7] V. Mootha,et al. Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system , 1999, FEBS Letters.
[8] M. Prentki,et al. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? , 2001, Diabetes.
[9] F. Ashcroft,et al. ATP-sensitive K+ channels and insulin secretion: their role in health and disease , 1999, Diabetologia.
[10] D. Coleman. Diabetes-Obesity Syndromes in Mice , 1982, Diabetes.
[11] H. Cortez‐Pinto,et al. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. , 1999, Gastroenterology.
[12] P. Gilon,et al. Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. , 1993, The Journal of clinical investigation.
[13] L. Leon,et al. Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3* , 2000, The Journal of Biological Chemistry.
[14] L. Tartaglia,et al. Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis , 1997, Diabetes.
[15] P. Gazzotti,et al. Recombinant human uncoupling protein‐3 increases thermogenesis in yeast cells , 1999, FEBS letters.
[16] V. Grill,et al. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. , 1990, Endocrinology.
[17] M. McBurney,et al. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. , 1987, Gene.
[18] Y. Hatefi. The mitochondrial electron transport and oxidative phosphorylation system. , 1985, Annual review of biochemistry.
[19] G. Shulman,et al. On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .
[20] M. Klingenberg,et al. Structure and function of the uncoupling protein from brown adipose tissue. , 1999, Biochimica et biophysica acta.
[21] E. Bonora,et al. Renal metabolism of C-peptide in man. , 1987, The Journal of clinical endocrinology and metabolism.
[22] C. Newgard,et al. Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. , 1999, Diabetes.
[23] O. Boss,et al. Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression , 1997, FEBS letters.
[24] M. Reitman,et al. Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin* , 1997, The Journal of Biological Chemistry.
[25] P. MacDonald,et al. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. , 1999, Diabetes.
[26] S. Kahn. The importance of the β-cell in the pathogenesis of type 2 diabetes mellitus , 2000 .
[27] P. Muzzin. The uncoupling proteins. , 2002, Annales d'endocrinologie.
[28] C. Kahn,et al. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. , 2000, The Journal of clinical investigation.
[29] M. Prentki,et al. Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. , 1999, American journal of physiology. Endocrinology and metabolism.
[30] H. Kowarzyk. Structure and Function. , 1910, Nature.
[31] Hitoshi Yamashita,et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese , 1997, nature.
[32] Christophe Fleury,et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia , 1997, Nature Genetics.
[33] G. Boden,et al. Effects of Lipid on Basal Carbohydrate Metabolism in Normal Men , 1991, Diabetes.
[34] Yun-ping Zhou,et al. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. , 1995, The Journal of clinical endocrinology and metabolism.
[35] W. Sivitz,et al. Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells* * This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569. , 2001, Endocrinology.
[36] P. Ronner,et al. Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP. , 1999, Analytical biochemistry.
[37] B. Lowell,et al. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. , 1997, Biochemical and biophysical research communications.
[38] J. Himms-Hagen,et al. Brown adipose tissue thermogenesis and obesity. , 1989, Progress in lipid research.
[39] J. Reilly,et al. Dietary fatty acids Up-regulate the expression of UCP2 in 3T3-L1 preadipocytes. , 2000, Biochemical and biophysical research communications.
[40] V. Skulachev. Uncoupling: new approaches to an old problem of bioenergetics. , 1998, Biochimica et biophysica acta.
[41] B. Miroux,et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production , 2000, Nature Genetics.
[42] J. Mayer,et al. Pancreatic Islets in Mice with the Obese-hyperglycemic Syndrome: Lack of Effect of Carbutamide , 1960, Diabetes.
[43] L. Aguilar-Bryan,et al. Sur1 Knockout Mice , 2000, The Journal of Biological Chemistry.
[44] Simeon I. Taylor,et al. Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene , 1992, Diabetes.
[45] I. Scheffler. Mitochondrial Electron Transport and Oxidative Phosphorylation , 2002 .
[46] A. Beloff-Chain,et al. Blood Glucose and Serum Insulin Levels in Lean and Genetically Obese Mice , 1975, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[47] R. DeFronzo. The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM , 1988, Diabetes.
[48] D. Sanchís,et al. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2 , 1999, The EMBO journal.
[49] W. Chung,et al. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) and electrophoretic assays for the mouse obese (Lepob) mutation. , 1997, Obesity research.
[50] Enrico Tronci. 1997 , 1997, Les 25 ans de l’OMC: Une rétrospective en photos.
[51] M. Mozzoli,et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. , 1991, The Journal of clinical investigation.
[52] L. Chao,et al. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. , 2000, The Journal of clinical investigation.
[53] B. Glaser,et al. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. , 1998, Diabetes.
[54] M. Prentki,et al. Long-Chain Fatty Acids Inhibit Acetyl-CoA Carboxylase Gene Expression in the Pancreatic β-Cell Line INS-1 , 1997, Diabetes.
[55] S. Brichard,et al. Marked Improvement of Glucose Homeostasis in Diabetic ob/ob Mice Given Oral Vanadate , 1990, Diabetes.
[56] V. Mootha,et al. Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice* , 2000, The Journal of Biological Chemistry.
[57] R. Robertson,et al. AN INTEGRATED VIEW OF β-CELL DYSFUNCTION IN TYPE-II DIABETES , 1996 .
[58] L. Tartaglia,et al. Transport Function and Regulation of Mitochondrial Uncoupling Proteins 2 and 3* , 1999, The Journal of Biological Chemistry.
[59] M. Klingenberg,et al. Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[60] M. Lindberg,et al. Adipose Tissue , 2018 .