AMPK activators: mechanisms of action and physiological activities

[1]  K. Guan,et al.  AMPK and autophagy in glucose/glycogen metabolism. , 2015, Molecular aspects of medicine.

[2]  P. Muti,et al.  Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis. , 2015, The Biochemical journal.

[3]  H. Gerstein,et al.  Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. , 2015, The Biochemical journal.

[4]  F. Ross,et al.  PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. , 2015, The Biochemical journal.

[5]  B. Kemp,et al.  Salicylate improves macrophage cholesterol homeostasis via activation of Ampk[S] , 2015, Journal of Lipid Research.

[6]  D. Hardie,et al.  AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. , 2015, Current opinion in cell biology.

[7]  J. Ha,et al.  Screening methods for AMP-activated protein kinase modulators: a patent review , 2015, Expert opinion on therapeutic patents.

[8]  Lorenzo Galluzzi,et al.  Metabolic Control of Autophagy , 2014, Cell.

[9]  B. Viollet,et al.  Metformin: from mechanisms of action to therapies. , 2014, Cell metabolism.

[10]  Ayumi Goto,et al.  Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles. , 2014, Biochemical and biophysical research communications.

[11]  D. Hardie AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels. , 2014, Annual review of nutrition.

[12]  B. Viollet,et al.  Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK , 2014, Chemistry & biology.

[13]  J. Brenman,et al.  Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators. , 2014, Pharmacology & therapeutics.

[14]  A. Shehzad,et al.  Role of AMP‐Activated Protein Kinase in Cancer Therapy , 2014, Archiv der Pharmazie.

[15]  S. Balk,et al.  Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis , 2014, Oncogene.

[16]  B. Kemp,et al.  Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. , 2014, Chemistry & biology.

[17]  M. Loda,et al.  A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis , 2014, EMBO molecular medicine.

[18]  Kyong Ju Jeong,et al.  AMP-activated protein kinase: An emerging target for ginseng , 2013, Journal of ginseng research.

[19]  Jongki Hong,et al.  Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma , 2014, Apoptosis.

[20]  David Carling,et al.  Structural basis of AMPK regulation by small molecule activators , 2013, Nature Communications.

[21]  D. Hardie,et al.  AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation , 2013, Cell metabolism.

[22]  S. Woods,et al.  Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats , 2013, Journal of Lipid Research.

[23]  K. Guan,et al.  Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy , 2013, Cell.

[24]  F. Giordanetto,et al.  Direct AMP-activated protein kinase activators: a review of evidence from the patent literature , 2012, Expert opinion on therapeutic patents.

[25]  Claudio R. Santos,et al.  Lipid metabolism in cancer , 2012, The FEBS journal.

[26]  B. Kemp,et al.  The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase , 2012, Science.

[27]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[28]  B. Kemp,et al.  AMPK functions as an adenylate charge-regulated protein kinase , 2012, Trends in Endocrinology & Metabolism.

[29]  I. Laher,et al.  Diabetes and Alpha Lipoic Acid , 2011, Front. Pharmacol..

[30]  Celestia S. Higano,et al.  New and emerging agents for the treatment of castration-resistant prostate cancer. , 2011, Urologic oncology.

[31]  R. Shaw,et al.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.

[32]  B. Kemp,et al.  AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase , 2011, Science.

[33]  J. Ha,et al.  AMP-activated protein kinase modulators: a patent review (2006 – 2010) , 2011, Expert opinion on therapeutic patents.

[34]  David Carling,et al.  Structure of Mammalian AMPK and its regulation by ADP , 2011, Nature.

[35]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[36]  B. Viollet,et al.  Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.

[37]  M. Loeken,et al.  AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy , 2011, Diabetologia.

[38]  D. Hardie,et al.  Conference on ‘ Nutrition and health : cell to community ’ Plenary Lecture Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism , 2011 .

[39]  Guido Kroemer,et al.  Autophagy and the integrated stress response. , 2010, Molecular cell.

[40]  B. Kemp,et al.  Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity* , 2010, The Journal of Biological Chemistry.

[41]  N. Mizushima,et al.  Autophagy in mammalian development and differentiation , 2010, Nature Cell Biology.

[42]  M. Erion,et al.  A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis. , 2010, ACS medicinal chemistry letters.

[43]  E. Abraham,et al.  Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase* , 2010, The Journal of Biological Chemistry.

[44]  M. Loda,et al.  New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK , 2010, Clinical Cancer Research.

[45]  B. Viollet,et al.  Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.

[46]  F. Ross,et al.  Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010, Cell metabolism.

[47]  D. Hardie,et al.  Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. , 2010, Biochimica et biophysica acta.

[48]  F. Ross,et al.  Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010 .

[49]  B. Viollet,et al.  AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. , 2009, American journal of physiology. Cell physiology.

[50]  D. Klionsky,et al.  Regulation mechanisms and signaling pathways of autophagy. , 2009, Annual review of genetics.

[51]  M. Czaja,et al.  Autophagy regulates adipose mass and differentiation in mice. , 2009, The Journal of clinical investigation.

[52]  I. Grummt,et al.  AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply , 2009, Proceedings of the National Academy of Sciences.

[53]  S. T. Mathews,et al.  Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. , 2009, Biochemical and biophysical research communications.

[54]  J. Menéndez,et al.  The active form of the metabolic sensor AMP-activated protein kinase α (AMPKα) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis , 2009, Cell cycle.

[55]  M. Czaja,et al.  Autophagy regulates lipid metabolism , 2009, Nature.

[56]  M. Donowitz,et al.  Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. , 2009, The Journal of clinical investigation.

[57]  B. Kemp,et al.  Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. , 2008, Chemistry & biology.

[58]  N. Musi,et al.  Advances in the development of AMPK-activating compounds , 2008, Expert opinion on drug discovery.

[59]  Suna Kim,et al.  The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. , 2008, Biochemical and biophysical research communications.

[60]  D. Hardie,et al.  AMPK: a key regulator of energy balance in the single cell and the whole organism , 2008, International Journal of Obesity.

[61]  M. Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2008, Cell.

[62]  B. Viollet,et al.  A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism , 2008, FEBS letters.

[63]  M. Gu,et al.  Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells* , 2008, Journal of Biological Chemistry.

[64]  Xu Huang,et al.  Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. , 2008, The Biochemical journal.

[65]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[66]  D. James,et al.  Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I , 2008, Diabetes.

[67]  Su-Jae Lee,et al.  Inhibition of AMP-activated Protein Kinase Sensitizes Cancer Cells to Cisplatin-induced Apoptosis via Hyper-induction of p53* , 2008, Journal of Biological Chemistry.

[68]  B. Viollet,et al.  Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase* , 2007, Journal of Biological Chemistry.

[69]  R. Heath,et al.  Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family* , 2007, Journal of Biological Chemistry.

[70]  Jun Ren,et al.  Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. , 2007, American journal of physiology. Cell physiology.

[71]  J. Menéndez,et al.  Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.

[72]  David Carling,et al.  Structural basis for AMP binding to mammalian AMP-activated protein kinase , 2007, Nature.

[73]  A. Leslie,et al.  Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols , 2007, Proceedings of the National Academy of Sciences.

[74]  J. Ha,et al.  Antidiabetes and Antiobesity Effect of Cryptotanshinone via Activation of AMP-Activated Protein Kinase , 2007, Molecular Pharmacology.

[75]  B. Viollet,et al.  A Conserved Sequence Immediately N-terminal to the Bateman Domains in AMP-activated Protein Kinase γ Subunits Is Required for the Interaction with the β Subunits* , 2007, Journal of Biological Chemistry.

[76]  J. Ha,et al.  Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase , 2007, Experimental & Molecular Medicine.

[77]  B. Kemp,et al.  AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling , 2007, Circulation research.

[78]  Gordon B. Mills,et al.  The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.

[79]  D. Hardie,et al.  AMP-activated protein kinase as a drug target. , 2007, Annual review of pharmacology and toxicology.

[80]  P. Puthanveetil,et al.  Ca 2 / calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by-lipoic acid in C 2 C 12 myotubes , 2007 .

[81]  J. Wojtaszewski,et al.  Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle , 2006, The Journal of physiology.

[82]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[83]  Etienne Waelkens,et al.  Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside , 2006, Molecular Cancer Therapeutics.

[84]  D. James,et al.  Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States , 2006, Diabetes.

[85]  N. LeBrasseur,et al.  Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. , 2006, American journal of physiology. Endocrinology and metabolism.

[86]  Minyoung Lee,et al.  Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma. , 2006, Biochemical pharmacology.

[87]  Kei Sakamoto,et al.  LKB1-dependent signaling pathways. , 2006, Annual review of biochemistry.

[88]  L. Kifle,et al.  Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. , 2006, Cell metabolism.

[89]  J. Richardson,et al.  Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. , 2006, Biochemical and biophysical research communications.

[90]  S. Moncada,et al.  Mitochondria as signaling organelles in the vascular endothelium. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[91]  J. McGuire,et al.  5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism. , 2006, Cancer research.

[92]  N. Musi AMP-activated protein kinase and type 2 diabetes. , 2006, Current medicinal chemistry.

[93]  J. Ha,et al.  Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. , 2005, Biochemical and biophysical research communications.

[94]  Min-Seon Kim,et al.  α-Lipoic Acid Prevents Endothelial Dysfunction in Obese Rats via Activation of AMP-Activated Protein Kinase , 2005 .

[95]  J. Eggermont,et al.  CBS domains: structure, function, and pathology in human proteins. , 2005, American journal of physiology. Cell physiology.

[96]  Min-Seon Kim,et al.  Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. , 2005, Biochemical and biophysical research communications.

[97]  R. Heath,et al.  Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.

[98]  B. Burwinkel,et al.  Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. , 2005, American journal of human genetics.

[99]  Russell G. Jones,et al.  AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.

[100]  Dario R Alessi,et al.  Metformin and reduced risk of cancer in diabetic patients , 2005, BMJ : British Medical Journal.

[101]  Min-Seon Kim,et al.  Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[102]  G. Hjälm,et al.  The 5′-AMP-activated Protein Kinase γ3 Isoform Has a Key Role in Carbohydrate and Lipid Metabolism in Glycolytic Skeletal Muscle* , 2004, Journal of Biological Chemistry.

[103]  M. Vincent,et al.  AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. , 2004, American journal of human genetics.

[104]  D. Hardie,et al.  AMP-Activated Protein Kinase: A Master Switch in Glucose and Lipid Metabolism , 2004, Reviews in Endocrine and Metabolic Disorders.

[105]  M. Roden,et al.  Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? , 2004, Diabetes.

[106]  M. Gleave,et al.  Dysregulation of Sterol Response Element-Binding Proteins and Downstream Effectors in Prostate Cancer during Progression to Androgen Independence , 2004, Cancer Research.

[107]  E. Kraegen,et al.  Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. , 2004, Biochemical and biophysical research communications.

[108]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[109]  B. Kemp Faculty Opinions recommendation of Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. , 2003 .

[110]  Jérôme Boudeau,et al.  Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.

[111]  David Carling,et al.  The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways* , 2002, The Journal of Biological Chemistry.

[112]  L. Goodyear,et al.  Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes. , 2002, Current drug targets. Immune, endocrine and metabolic disorders.

[113]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[114]  M. Kaminishi,et al.  Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. , 2001, Biochemical and biophysical research communications.

[115]  S. J. Kim,et al.  The regulation of AMP-activated protein kinase by H(2)O(2). , 2001, Biochemical and biophysical research communications.

[116]  Jianbiao Zheng,et al.  Inhibition of mitochondrial proton F0F1‐ATPase/ATP synthase by polyphenolic phytochemicals , 2000, British journal of pharmacology.

[117]  M. Owen,et al.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.

[118]  D. Carling,et al.  The regulation of AMP-activated protein kinase by phosphorylation. , 2000, The Biochemical journal.

[119]  A. Hemminki The molecular basis and clinical aspects of Peutz-Jeghers syndrome , 1999, Cellular and Molecular Life Sciences CMLS.

[120]  A. Prescott,et al.  AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. , 1998, The Biochemical journal.

[121]  J. Swinnen,et al.  Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[122]  S. Hawley,et al.  Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase* , 1996, The Journal of Biological Chemistry.

[123]  D. Hardie,et al.  5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2Ac , 1995, FEBS letters.

[124]  L. Riechmann,et al.  An antibody VH domain with a lox‐Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain , 1995, FEBS letters.

[125]  A. Edelman,et al.  5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*) , 1995, The Journal of Biological Chemistry.

[126]  S. Hawley,et al.  5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? , 1995, European journal of biochemistry.

[127]  D. Hardie,et al.  5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? , 1995, European journal of biochemistry.

[128]  D. Carling,et al.  Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase , 1994, FEBS letters.

[129]  F. Bontemps,et al.  Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes. , 1992, The Biochemical journal.

[130]  M. Vincent,et al.  Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes , 1991, Diabetes.