MUGEN mouse database; Animal models of human immunological diseases

The MUGEN mouse database (MMdb) (www.mugen-noe.org/database/) is a database of murine models of immune processes and immunological diseases. Its aim is to share and publicize information on mouse strain characteristics and availability from participating institutions. MMdb's basic classification of models is based on three major research application categories: Models of Human Disease, Models of Immune Processes and Transgenic Tools. Data on mutant strains includes detailed information on affected gene(s), mutant allele(s) and genetic background (DNA origin, gene targeted, host and backcross strain background). Each gene/transgene index also includes IDs and direct links to Ensembl, ArrayExpress, EURExpress and NCBI's Entrez Gene database. Phenotypic description is standardized and hierarchically structured, based on MGI's mammalian phenotypic ontology terms. Availability (e.g. live mice, cryopreserved embryos, sperm and ES cells) is clearly indicated, along with handling and genotyping details (in the form of documents or hyperlinks) and all relevant contact information (including EMMA and Jax/IMSR hyperlinks where available). MMdb's design offers a user-friendly query interface and provides instant access to the list of mutant strains and genes. Database access is free of charge and there are no registration requirements for data querying.

[1]  J. Eppig,et al.  Visualizing the Laboratory Mouse: Capturing Phenotype Information , 2004, Genetica.

[2]  Andreas Prlic,et al.  Ensembl 2007 , 2006, Nucleic Acids Res..

[3]  Martin Ringwald,et al.  Mouse Genome Informatics (MGI) Resources for Pathology and Toxicology , 2007, Toxicologic pathology.

[4]  J A Blake,et al.  Program description: Strategies for biological annotation of mammalian systems: implementing gene ontologies in mouse genome informatics. , 2001, Genomics.

[5]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[6]  M. Eisen.  All motifs are NOT created equal: structural properties of transcription factor-DNA interactions and the inference of sequence specificity , 2005, Genome Biology.

[7]  Cynthia L. Smith,et al.  The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information , 2004, Genome Biology.

[8]  Helen E. Parkinson,et al.  ArrayExpress—a public database of microarray experiments and gene expression profiles , 2006, Nucleic Acids Res..

[9]  John M. Hancock,et al.  Using ontologies to describe mouse phenotypes , 2004, Genome Biology.

[10]  Judith A. Blake,et al.  The mouse genome database (MGD): new features facilitating a model system , 2006, Nucleic Acids Res..

[11]  Yi Xing,et al.  Evidence of functional selection pressure for alternative splicingevents that accelerate evolution of protein subsequences , 2005, Genome Biology.