The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism

[1]  Pedro R. Magalhães,et al.  Constant-pH Molecular Dynamics Study of Kyotorphin in an Explicit Bilayer. , 2015, Biophysical journal.

[2]  E. Bardaji,et al.  DEPBT as Coupling Reagent To Avoid Racemization in a Solution-Phase Synthesis of a Kyotorphin Derivative , 2014, Synthesis.

[3]  Sónia Sá Santos,et al.  Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs , 2013, Amino Acids.

[4]  J. Hohlfeld,et al.  LPS-Induced Lung Inflammation in Marmoset Monkeys – An Acute Model for Anti-Inflammatory Drug Testing , 2012, PloS one.

[5]  Inês M Torcato,et al.  Antimicrobial properties of analgesic kyotorphin peptides unraveled through atomic force microscopy. , 2012, Biochemical and biophysical research communications.

[6]  M. Phillipson,et al.  Decreased leukocyte recruitment by inorganic nitrate and nitrite in microvascular inflammation and NSAID-induced intestinal injury. , 2012, Free radical biology & medicine.

[7]  Marco M. Domingues,et al.  Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. , 2012, Biopolymers.

[8]  C. Ghelardini,et al.  Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties. , 2011, Journal of medicinal chemistry.

[9]  S. Maier,et al.  Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia , 2011, Pharmacological Reviews.

[10]  Marco M. Domingues,et al.  Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia. , 2011, Molecular pharmaceutics.

[11]  M. Castanho,et al.  Inhibition of nociceptive responses after systemic administration of amidated kyotorphin , 2011, British journal of pharmacology.

[12]  Roberto Weigert,et al.  Intravital microscopy as a tool to study drug delivery in preclinical studies. , 2011, Advanced drug delivery reviews.

[13]  A. Lipkowski,et al.  Opioid peptides in peripheral pain control. , 2011, Acta neurobiologiae experimentalis.

[14]  S. Hua,et al.  Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications. , 2010, Trends in pharmacological sciences.

[15]  C. Soares,et al.  Membrane-induced conformational changes of kyotorphin revealed by molecular dynamics simulations. , 2010, The journal of physical chemistry. B.

[16]  L. Boscá,et al.  ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration. , 2010, Cardiovascular research.

[17]  Wilfred F. van Gunsteren,et al.  A new force field for simulating phosphatidylcholine bilayers , 2010, J. Comput. Chem..

[18]  F. Gavins,et al.  Troubleshooting methods: Using intravital microscopy in drug research. , 2010, Journal of pharmacological and toxicological methods.

[19]  Miguel A. R. B. Castanho,et al.  rBPI21 Promotes Lipopolysaccharide Aggregation and Exerts Its Antimicrobial Effects by (Hemi)fusion of PG-Containing Membranes , 2009, PloS one.

[20]  M. Lopes-Ferreira,et al.  Characterization of a new bioactive peptide from Potamotrygon gr. orbignyi freshwater stingray venom , 2009, Peptides.

[21]  P. Kubes,et al.  Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. , 2009, The Journal of clinical investigation.

[22]  Jae Woong Lee,et al.  Journal of Neuroinflammation Neuro-inflammation Induced by Lipopolysaccharide Causes Cognitive Impairment through Enhancement of Beta-amyloid Generation , 2022 .

[23]  J. Scherrmann,et al.  CNS Delivery Via Adsorptive Transcytosis , 2008, The AAPS Journal.

[24]  Maria Luisa Mangoni,et al.  Lipopolysaccharide, a Key Molecule Involved in the Synergism between Temporins in Inhibiting Bacterial Growth and in Endotoxin Neutralization* , 2008, Journal of Biological Chemistry.

[25]  Carsten Kutzner,et al.  GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. , 2008, Journal of chemical theory and computation.

[26]  Á. Meana,et al.  Endogenous β-endorphin induces thermal analgesia at the initial stages of a murine osteosarcoma , 2006, Peptides.

[27]  D. Borsook,et al.  Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges , 2006, Journal of Pharmacology and Experimental Therapeutics.

[28]  D. Scheidegger,et al.  Peptide drugs, overcoming the challenges, a growing business , 2006 .

[29]  William Schulz,et al.  TAKING AIM AT MELANOMA , 2005 .

[30]  M. Koch,et al.  Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide. , 2005, Biophysical journal.

[31]  Sabita Roy,et al.  Morphine Impairs Host Innate Immune Response and Increases Susceptibility to Streptococcus pneumoniae Lung Infection1 , 2005, The Journal of Immunology.

[32]  Chris Oostenbrink,et al.  A biomolecular force field based on the free enthalpy of hydration and solvation: The GROMOS force‐field parameter sets 53A5 and 53A6 , 2004, J. Comput. Chem..

[33]  E. Pålsson-McDermott,et al.  Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4 , 2004, Immunology.

[34]  F. Gavins,et al.  Intravital microscopy for the study of mouse microcirculation in anti-inflammatory drug research: focus on the mesentery and cremaster preparations. , 2004, Journal of pharmacological and toxicological methods.

[35]  C. Stein,et al.  Different mechanisms of intrinsic pain inhibition in early and late inflammation , 2003, Journal of Neuroimmunology.

[36]  A. Quyyumi.  Prognostic value of endothelial function. , 2003, The American journal of cardiology.

[37]  N. Santos,et al.  Evaluation of Lipopolysaccharide Aggregation by Light Scattering Spectroscopy , 2003, Chembiochem : a European journal of chemical biology.

[38]  Jonathan Cohen.  The immunopathogenesis of sepsis , 2002, Nature.

[39]  R. Gold,et al.  Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders , 2001, Journal of Neuroimmunology.

[40]  I. M. Santalova,et al.  Effects of L-thyrosyl - L-arginine (kyotorphin) on the behavior of rats and goldfish , 2000, Peptides.

[41]  J. Mitchell,et al.  Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy , 1999, British journal of pharmacology.

[42]  R. Ulevitch,et al.  Recognition of gram-negative bacteria and endotoxin by the innate immune system. , 1999, Current opinion in immunology.

[43]  A. J. Shaka,et al.  Multiple-pulse mixing sequences that selectively enhance chemical exchange or cross-relaxation peaks in high-resolution NMR spectra. , 1998, Journal of magnetic resonance.

[44]  R I Lehrer,et al.  Antimicrobial peptides of vertebrates. , 1998, Current opinion in immunology.

[45]  K. Takeuchi,et al.  Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. , 1997, The Journal of clinical investigation.

[46]  T. Eisenstein,et al.  Morphine induces sepsis in mice. , 1997, The Journal of infectious diseases.

[47]  N. Surolia,et al.  Titration calorimetric studies to elucidate the specificity of the interactions of polymyxin B with lipopolysaccharides and lipid A. , 1996, The Biochemical journal.

[48]  S. Grzesiek,et al.  NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.

[49]  E. Jakobsson,et al.  Incorporation of surface tension into molecular dynamics simulation of an interface: a fluid phase lipid bilayer membrane. , 1995, Biophysical journal.

[50]  Bruce A. Johnson,et al.  NMR View: A computer program for the visualization and analysis of NMR data , 1994, Journal of biomolecular NMR.

[51]  M. Vaara,et al.  Agents that increase the permeability of the outer membrane. , 1992, Microbiological reviews.

[52]  H. Ueda,et al.  Isolation and identification of an analgesic opioid dipeptide kyotorphin (TYR-ARG) from bovine brain , 1981, Neuropharmacology.

[53]  H. Ueda,et al.  Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (Kyotorphin) and its analogue. , 1979, European journal of pharmacology.

[54]  S. Baez,et al.  An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. , 1973, Microvascular research.