New abietane-type diterpene glycosides from the roots of Tripterygium wilfordii

Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination with chemical reactions.

[1]  Ping Li,et al.  Chemical comparison of Tripterygium wilfordii and Tripterygium hypoglaucum based on quantitative analysis and chemometrics methods. , 2014, Journal of pharmaceutical and biomedical analysis.

[2]  Mouming Zhao,et al.  Identification of sesquilignans in litchi (Litchi chinensis Sonn.) leaf and their anticancer activities , 2014 .

[3]  Hong-Guang Jin,et al.  Three new lignan glycosides with IL-6 inhibitory activity from Akebia quinata. , 2014, Chemical & pharmaceutical bulletin.

[4]  Xing Zhang,et al.  Isolation and insecticidal activity of sesquiterpenes alkaloids from Tripterygium wilfordii Hook f. , 2014 .

[5]  Zhi‐Jun Zhang,et al.  Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. , 2014, Bioorganic & medicinal chemistry.

[6]  Guoqing Li,et al.  Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression , 2013, PloS one.

[7]  C. Kuo,et al.  Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide–Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1 , 2013, The Journal of Immunology.

[8]  A. Braca,et al.  Terpenoids from the leaves of Podocarpus gracilior , 2012 .

[9]  Chaozhan Lin,et al.  Three new flavonol glycosides from Nervilia fordii , 2012 .

[10]  G. Sethi,et al.  Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. , 2011, Cancer letters.

[11]  Zhongjun Ma,et al.  Terpenoids from Tripterygium wilfordii. , 1997, Phytochemistry.

[12]  Li Huang,et al.  Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. , 2010, Journal of medicinal chemistry.

[13]  Xiaomin Wang,et al.  Triptolide inhibits COX‐2 expression and PGE2 release by suppressing the activity of NF‐κB and JNK in LPS‐treated microglia , 2008, Journal of neurochemistry.

[14]  P. Lipsky,et al.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). , 2007, Phytochemistry.

[15]  Cheng Xiao,et al.  Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice. , 2007, Biochemical pharmacology.

[16]  Guangzhong Yang,et al.  Cyclopeptide and terpenoids from Tripterygium wilfordii HOOK. F. , 2002 .

[17]  C. H. Chen,et al.  The role of the third β strand in gp120 conformation and neutralization sensitivity of the HIV-1 primary isolate DH012 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  P. Lipsky,et al.  The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. , 2000, Rheumatic diseases clinics of North America.

[19]  D. Li,et al.  Immunosuppressive diterpenoids from Tripterygium wilfordii. , 1999, Journal of natural products.

[20]  L. Davis,et al.  Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness. , 1991, Arthritis and rheumatism.

[21]  R. Robinson.  Phytochemistry , 1962, Nature.

[22]  Billy R. Hammond,et al.  [Foods]. , 1953, El Dia medico.