HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models
暂无分享,去创建一个
O. O’Connor | X. An | Faming Zhang | Yueying Wang | R. Sun | B. Mao | Lingxin Xiong | Lei Zhang | Xiaolong Tu | Jingjing Wang | Xiangfei He | Shengfu Guo | Cunxiang Ju | Qi-Xiang Li | Hang Ke | Cen Chen
[1] Yongping Song,et al. SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal , 2022, Journal of Hematology & Oncology.
[2] Y. Kong,et al. A Multicenter, Single-Arm, Phase II Trial of RC48-ADC Combined with Radiotherapy, PD-1/PD-L1 Inhibitor Sequential GM-CSF and IL-2 (PRaG3.0 regimen) for the Treatment of HER2-Expressing Advanced Solid Tumors , 2022, International Journal of Radiation Oncology*Biology*Physics.
[3] L. Miller,et al. Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response , 2022, Journal for immunotherapy of cancer.
[4] R. Akbani,et al. Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma. , 2022, Cancer cell.
[5] M. Cam,et al. Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice , 2022, Oncoimmunology.
[6] Zhichen Sun,et al. Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity , 2022, The Journal of clinical investigation.
[7] J. Minna,et al. Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors , 2021, Science Translational Medicine.
[8] E. Yang,et al. Anti-CD47 Monoclonal Antibody–Drug Conjugate: A Targeted Therapy to Treat Triple-Negative Breast Cancers , 2021, Vaccines.
[9] Wang Jing,et al. Anlotinib in combination with TQB2450 in patients with recurrent ovarian cancer (ACTION): A multicenter, single-arm, open-label, phase Ib trial. , 2021 .
[10] Shuiping Gao,et al. Phase I study of pucotenlimab (HX008), an anti-PD-1 antibody, for patients with advanced solid tumors , 2021, Therapeutic advances in medical oncology.
[11] Jianming Xu,et al. Anti-PD-1 antibody HX008 combined with oxaliplatin plus capecitabine for advanced gastric or esophagogastric junction cancer: a multicenter, single-arm, open-label, phase Ib trial , 2020, Oncoimmunology.
[12] Yunpeng Liu,et al. HX008, an anti-PD1 antibody, plus irinotecan as second-line treatment for advanced gastric or gastroesophageal junction cancer: a multicenter, single-arm phase II trial , 2020, Journal for ImmunoTherapy of Cancer.
[13] I. Weissman,et al. Targeting macrophage checkpoint inhibitor SIRPa for anticancer therapy. , 2020, JCI insight.
[14] K. Akashi,et al. Combination of CD47 and signal‐regulatory protein‐α constituting the “don’t eat me signal” is a prognostic factor in diffuse large B‐cell lymphoma , 2020, Cancer science.
[15] I. Weissman,et al. Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies , 2020, Frontiers in Oncology.
[16] Ying Huang,et al. HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties , 2020, mAbs.
[17] L. Ridnour,et al. Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation , 2019, Cancer Immunology, Immunotherapy.
[18] Betty Y. S. Kim,et al. Phagocytosis checkpoints as new targets for cancer immunotherapy , 2019, Nature Reviews Cancer.
[19] Chuang Chen,et al. Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients , 2019, Cancer Cell International.
[20] Bo Peng,et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit , 2019, mAbs.
[21] Chuang Chen,et al. High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis , 2019, Oncology letters.
[22] Y. Xi,et al. Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia. , 2019, Pathology, research and practice.
[23] Yijian Li. CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma. , 2019, The New England journal of medicine.
[24] I. Weissman,et al. CD47 Blockade by Hu5F9‐G4 and Rituximab in Non‐Hodgkin's Lymphoma , 2018, The New England journal of medicine.
[25] Demin Zhou,et al. Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry. , 2018, Journal of visualized experiments : JoVE.
[26] Sheng Guo,et al. The design, analysis and application of mouse clinical trials in oncology drug development , 2018, BMC Cancer.
[27] C. Querfeld,et al. Targeting CD47 as a cancer therapeutic strategy: the cutaneous T-cell lymphoma experience , 2018, Current opinion in oncology.
[28] yang-xin fu,et al. Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion. , 2018, Cell reports.
[29] K. Tarte,et al. Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia , 2018, Molecular Cancer Therapeutics.
[30] Juanjuan Su,et al. Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice , 2018, Cell Research.
[31] Ya-jun Guo,et al. Elimination of tumor by CD47/PD-L1 dual-targeting fusion protein that engages innate and adaptive immune responses , 2018, mAbs.
[32] S. Rodig,et al. Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma. , 2017, Blood advances.
[33] Hongliang Yu,et al. Targeting CD47 Enhances the Efficacy of Anti-PD-1 and CTLA-4 in an Esophageal Squamous Cell Cancer Preclinical Model. , 2017, Oncology research.
[34] V. Lee,et al. TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets , 2017, PloS one.
[35] Junzhi Wang,et al. Development of a robust reporter gene assay to measure the bioactivity of anti‐PD‐1/anti‐PD‐L1 therapeutic antibodies , 2017, Journal of pharmaceutical and biomedical analysis.
[36] Qi-Xiang Li,et al. Experimental animal modeling for immuno-oncology. , 2017, Pharmacology & therapeutics.
[37] Zihai Li,et al. Is CD47 an innate immune checkpoint for tumor evasion? , 2017, Journal of Hematology & Oncology.
[38] Qi-Xiang Li,et al. Molecular Pathology of Patient Tumors, Patient-Derived Xenografts, and Cancer Cell Lines. , 2016, Cancer research.
[39] I. Weissman,et al. First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[40] R. Majeti,et al. SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells , 2016, Clinical Cancer Research.
[41] Jedd D. Wolchok,et al. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations , 2016, Science Translational Medicine.
[42] J. Wery,et al. A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations , 2015, Oncotarget.
[43] Joshua M. Korn,et al. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response , 2015, Nature Medicine.
[44] yang-xin fu,et al. CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors , 2015, Nature Medicine.
[45] S. Ansell. Targeting immune checkpoints in lymphoma , 2015, Current opinion in hematology.
[46] R. Majeti,et al. A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells , 2015, mAbs.
[47] G. Freeman,et al. The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma. , 2015, Clinical therapeutics.
[48] M. Millenson,et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. , 2015, The New England journal of medicine.
[49] J. Berzofsky,et al. CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy. , 2014, Cancer research.
[50] K. Akashi,et al. The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. , 2014, Experimental hematology.
[51] K. Akashi,et al. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. , 2013, Blood.
[52] Junjie Lu,et al. Overcoming erlotinib resistance with tailored treatment regimen in patient‐derived xenografts from naïve Asian NSCLC patients , 2013, International journal of cancer.
[53] Aik Choon Tan,et al. Patient-derived tumour xenografts as models for oncology drug development , 2012, Nature Reviews Clinical Oncology.
[54] I. Weissman,et al. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells , 2012, Leukemia.
[55] Jens-Peter Volkmer,et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors , 2012, Proceedings of the National Academy of Sciences.
[56] Ash A. Alizadeh,et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. , 2011, Cancer research.
[57] Ash A. Alizadeh,et al. Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma , 2010, Cell.
[58] M. Caligiuri,et al. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. , 2005, Blood.
[59] Demin Zhou,et al. In Vivo Pharmacology Models for Cancer Target Research. , 2019, Methods in molecular biology.