De Novo Design of a βαβ Motif

Ein masgeschneidertes monomeres Protein mit βαβ-Faltung, bei der zwei parallele β-Strange uber eine α-Helix verknupft sind (siehe Struktur), wurde ausschlieslich aus codierten Aminosauren konstruiert. Die hohe thermische Bestandigkeit dieser Struktur beruht auf ausgedehnten Tryptophan-Tryptophan-Wechselwirkungen zwischen den beiden β-Strangen.

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