Deep-learning powered whispering gallery mode sensor based on multiplexed imaging at fixed frequency

During the last decades the whispering gallery mode based sensors have become a prominent solution for label-free sensing of various physical and chemical parameters. At the same time, the widespread utilization of the approach is hindered by the restricted applicability of the known configurations for ambient variations quantification outside the laboratory conditions and their low affordability, where necessity on the spectrally-resolved data collection is among the main limiting factors. In this paper we demonstrate the first realization of an affordable whispering gallery mode sensor powered by deep learning and multi-resonator imaging at a fixed frequency. It has been shown that the approach enables refractive index unit (RIU) prediction with an absolute error at 3×10-6 level for dynamic range of the RIU variations from 0 to 2×10-3 with temporal resolution of several milliseconds and instrument-driven detection limit of 3×10−5. High sensing accuracy together with instrumental affordability and production simplicity places the reported detector among the most cost-effective realizations of the whispering gallery mode approach. The proposed solution is expected to have a great impact on the shift of the whole sensing paradigm away from the model-based and to the flexible self-learning solutions.

[1]  Peter D. Wentzell,et al.  Detection Limits of Chemical Sensors: Applications and Misapplications , 2012 .

[2]  Dieter Braun,et al.  Protein detection by optical shift of a resonant microcavity , 2002 .

[3]  Matthew R Foreman,et al.  Whispering gallery mode sensors. , 2015, Advances in optics and photonics.

[4]  Lan Yang,et al.  Single Nanoparticle Detection Using Optical Microcavities , 2017, Advanced materials.

[5]  Steven H. Huang,et al.  Whispering-Gallery Sensors , 2020, Matter.

[6]  Benjamin Richter,et al.  On-chip microlasers for biomolecular detection via highly localized deposition of a multifunctional phospholipid ink. , 2013, Lab on a chip.

[7]  K. Vahala Optical microcavities , 2003, Nature.

[8]  Lan Yang,et al.  Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices , 2012 .

[9]  A. Dorofeenko,et al.  Machine Learning for Optical Gas Sensing: A Leaky-Mode Humidity Sensor as Example , 2020, IEEE Sensors Journal.

[10]  Frank Vollmer,et al.  Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution , 2016, Nature Photonics.

[11]  E. A. Tcherniavskaia,et al.  Using optical resonance of whispering gallery modes in microspheres for real-time detection and identification of biological compounds , 2010 .

[12]  Silvia Soria,et al.  Biosensing by WGM Microspherical Resonators , 2016, Sensors.

[13]  Stephen Holler,et al.  Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. , 2013, Nano letters.

[14]  Judith Su,et al.  Label-Free Biological and Chemical Sensing Using Whispering Gallery Mode Optical Resonators: Past, Present, and Future , 2017, Sensors.

[15]  S. Ozdemir,et al.  Detecting single viruses and nanoparticles using whispering gallery microlasers. , 2011, Nature nanotechnology.

[16]  Bernhard Roth,et al.  All-polymer whispering gallery mode sensor system. , 2016, Optics express.

[17]  E. A. Tcherniavskaia,et al.  Application of neural networks for classification of biological compounds from the characteristics of whispering-gallery-mode optical resonance , 2011 .

[18]  Heath A. Huckabay,et al.  Label-free detection of ovarian cancer biomarkers using whispering gallery mode imaging. , 2013, Biosensors & bioelectronics.

[19]  Lan Yang,et al.  Exceptional points enhance sensing in an optical microcavity , 2017, Nature.

[20]  Kerry J. Vahala,et al.  Fabrication and coupling to planar high-Q silica disk microcavities , 2003 .

[21]  T. J. Kippenberg,et al.  Ultra-high-Q toroid microcavity on a chip , 2003, Nature.

[22]  Weisheng Hu,et al.  Multi-Parameter Sensing in a Multimode Self-Interference Micro-Ring Resonator by Machine Learning , 2020, Sensors.

[23]  Yong Zhao,et al.  Optical bio-chemical sensors based on whispering gallery mode resonators. , 2018, Nanoscale.

[24]  S. Arnold,et al.  Whispering-gallery-mode biosensing: label-free detection down to single molecules , 2008, Nature Methods.

[25]  Yong Zhao,et al.  Whispering Gallery Mode Optical Microresonators: Structures and Sensing Applications , 2020, physica status solidi (a).

[26]  Joachim Knittel,et al.  Detection of nanoparticles with a frequency locked whispering gallery mode microresonator , 2013, 1303.1174.

[27]  Aydogan Ozcan,et al.  Computational Sensing Using Low-Cost and Mobile Plasmonic Readers Designed by Machine Learning. , 2017, ACS nano.

[28]  Serge Rosenblum,et al.  Cavity ring-up spectroscopy for ultrafast sensing with optical microresonators , 2015, Nature Communications.

[29]  T. Weigel,et al.  Microresonator array for high-resolution spectroscopy. , 2007 .

[30]  A. Ostendorf,et al.  Reusable Dispersed Resonators-Based Biochemical Sensor for Parallel Probing , 2019, IEEE Sensors Journal.

[31]  Vladimir S. Ilchenko,et al.  Quality-factor and nonlinear properties of optical Whispering-Gallery modes , 1989 .

[32]  Vladimir A. Saetchnikov,et al.  Mapping of the detecting units of the resonator-based multiplexed sensor , 2018, Photonics Europe.

[33]  Wei Pang,et al.  Performance and noise analysis of optical microresonator-based biochemical sensors using intensity detection. , 2016, Optics express.

[34]  Xudong Fan,et al.  Liquid-core optical ring-resonator sensors. , 2006, Optics letters.

[35]  D. Holdstock Past, present--and future? , 2005, Medicine, conflict, and survival.

[36]  N. Riesen,et al.  Fluorescent and lasing whispering gallery mode microresonators for sensing applications , 2017 .