A new tumor-specific variant of GRP78 as target for antibody-based therapy

[1]  S. Groshen,et al.  Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. , 2007, Human pathology.

[2]  Amy S. Lee,et al.  ER chaperones in mammalian development and human diseases , 2007, FEBS letters.

[3]  Wei Wang,et al.  VP-16 resistance in the NCI-H460 human lung cancer cell line is significantly associated with glucose-regulated protein78 (GRP78) induction. , 2007, Anticancer research.

[4]  Amy S. Lee.  GRP78 induction in cancer: therapeutic and prognostic implications. , 2007, Cancer research.

[5]  Y. Liu,et al.  Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery. , 2007, Molecular pharmaceutics.

[6]  S. Fang,et al.  Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer , 2007, Clinical & Experimental Metastasis.

[7]  H. Müller-Hermelink,et al.  The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein , 2007, Molecular Cancer Therapeutics.

[8]  S. Calderwood,et al.  Role of Scavenger Receptors in the Binding and Internalization of Heat Shock Protein 701 , 2006, The Journal of Immunology.

[9]  H. Vollmers,et al.  Natural IgM antibodies: from parias to parvenus. , 2006, Histology and histopathology.

[10]  S. Pizzo,et al.  Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. , 2006, Cancer research.

[11]  S. Groshen,et al.  Expression of Stress Response Protein Grp78 Is Associated with the Development of Castration-Resistant Prostate Cancer , 2006, Clinical Cancer Research.

[12]  S. Groshen,et al.  GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. , 2006, Cancer research.

[13]  Amy S. Lee,et al.  Glucose regulated proteins in cancer progression, Drug resistance and immunotherapy , 2006, Cancer biology & therapy.

[14]  S. Pizzo,et al.  Activation and Cross-talk between Akt, NF-κB, and Unfolded Protein Response Signaling in 1-LN Prostate Cancer Cells Consequent to Ligation of Cell Surface-associated GRP78* , 2006, Journal of Biological Chemistry.

[15]  S. Tsutsumi,et al.  Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells , 2006, Oncogene.

[16]  C. Koumenis.  ER stress, hypoxia tolerance and tumor progression. , 2006, Current molecular medicine.

[17]  Amy S. Lee,et al.  Stress induction of GRP78/BiP and its role in cancer. , 2006, Current molecular medicine.

[18]  T. Ranheim,et al.  Retention of Mutant Low Density Lipoprotein Receptor in Endoplasmic Reticulum (ER) Leads to ER Stress* , 2006, Journal of Biological Chemistry.

[19]  A. Koong,et al.  The Unfolded Protein Response: A Novel Component of the Hypoxic Stress Response in Tumors , 2005, Molecular Cancer Research.

[20]  Raymond Sawaya,et al.  The role of autophagy in cancer development and response to therapy , 2005, Nature Reviews Cancer.

[21]  P. Cossart,et al.  Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein , 2005, The EMBO journal.

[22]  C. Liu,et al.  Regulation of Tissue Factor—Mediated Initiation of the Coagulation Cascade by Cell Surface Grp78 , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[23]  R. Tiwari,et al.  Differences in glycosylation patterns of heat shock protein, gp96: implications for prostate cancer prevention. , 2005, Cancer research.

[24]  H. Vollmers,et al.  The "early birds": natural IgM antibodies and immune surveillance. , 2005, Histology and histopathology.

[25]  J. Esko,et al.  The sweet and sour of cancer: glycans as novel therapeutic targets , 2005, Nature Reviews Cancer.

[26]  M. Morita,et al.  Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. , 2005, Lung cancer.

[27]  S. Bates,et al.  Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment. , 2005, Cancer research.

[28]  C. Bertozzi,et al.  Glycans in cancer and inflammation — potential for therapeutics and diagnostics , 2005, Nature Reviews Drug Discovery.

[29]  D. Egan,et al.  Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78. , 2005, Cancer research.

[30]  Seung-Oe Lim,et al.  Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. , 2005, World journal of gastroenterology.

[31]  H. Vollmers,et al.  Death by stress: natural IgM-induced apoptosis. , 2005, Methods and findings in experimental and clinical pharmacology.

[32]  S. Pizzo,et al.  The Role of MTJ-1 in Cell Surface Translocation of GRP78, a Receptor for α2-Macroglobulin-Dependent Signaling1 , 2005, The Journal of Immunology.

[33]  L. Hendershot,et al.  The role of the unfolded protein response in tumour development: friend or foe? , 2004, Nature Reviews Cancer.

[34]  L. Hendershot,et al.  The ER function BiP is a master regulator of ER function. , 2004, The Mount Sinai journal of medicine, New York.

[35]  W. Arap,et al.  Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. , 2004, Cancer cell.

[36]  S. Pizzo,et al.  A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. , 2004, Cellular signalling.

[37]  M. Dwek,et al.  Harnessing changes in cellular glycosylation in new cancer treatment strategies. , 2004, Current cancer drug targets.

[38]  H. Müller-Hermelink,et al.  Lipoptosis: tumor-specific cell death by antibody-induced intracellular lipid accumulation. , 2004, Cancer research.

[39]  S. Pizzo,et al.  Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells. , 2004, Cellular signalling.

[40]  D. Smith,et al.  Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2 , 2004, Archives of Virology.

[41]  H. Müller-Hermelink,et al.  Natural IgM antibodies and immunosurveillance mechanisms against epithelial cancer cells in humans. , 2003, Cancer research.

[42]  K. Mori,et al.  Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. , 2003, Journal of Hepatology.

[43]  H. Müller-Hermelink,et al.  Cysteine-rich fibroblast growth factor receptor 1, a new marker for precancerous epithelial lesions defined by the human monoclonal antibody PAM-1. , 2003, Cancer research.

[44]  S. Pizzo,et al.  The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. , 2002, The Journal of biological chemistry.

[45]  D. Fradelizi,et al.  GRP78, a Coreceptor for Coxsackievirus A9, Interacts with Major Histocompatibility Complex Class I Molecules Which Mediate Virus Internalization , 2002, Journal of Virology.

[46]  Y. Park,et al.  Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade. , 2001, Cancer research.

[47]  H. Müller-Hermelink,et al.  Regulation of the New Coexpressed CD55 (Decay-Accelerating Factor) Receptor on Stomach Carcinoma Cells Involved in Antibody SC-1–Induced Apoptosis , 2001, Laboratory Investigation.

[48]  Amy S. Lee,et al.  The glucose-regulated proteins: stress induction and clinical applications. , 2001, Trends in biochemical sciences.

[49]  D. Fradelizi,et al.  Major histocompatibility class one molecule associates with glucose regulated protein (GRP) 78 on the cell surface. , 2001, Human immunology.

[50]  M. Mann,et al.  A Novel Proliferation-Associated Variant of CFR-1 Defined by a Human Monoclonal Antibody , 2001, Laboratory Investigation.

[51]  J. Dennis,et al.  Glycoprotein glycosylation and cancer progression. , 1999, Biochimica et biophysica acta.

[52]  M. Mann,et al.  Characterization of glycosylphosphatidylinositol-linked molecule CD55/decay-accelerating factor as the receptor for antibody SC-1-induced apoptosis. , 1999, Cancer research.

[53]  M. Volm,et al.  Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas. , 1999, Anticancer research.

[54]  H. Müller-Hermelink,et al.  Mitogenic autoantibodies in Helicobacter pylori‐associated stomach cancerogenesis , 1999, International journal of cancer.

[55]  Amy S. Lee,et al.  De‐regulation of GRP stress protein expression in human breast cancer cell lines , 1999, Breast Cancer Research and Treatment.

[56]  J. Kiang,et al.  Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. , 1998, Pharmacology & therapeutics.

[57]  Amy S. Lee,et al.  Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[58]  R. Gatenby,et al.  The potential role of transformation-induced metabolic changes in tumor-host interaction. , 1995, Cancer research.

[59]  S. Patierno,et al.  Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions , 2004, Breast Cancer Research and Treatment.

[60]  P. Piselli,et al.  Cell surface localization of the 78 kD glucose regulated protein (GRP 78) induced by thapsigargin. , 1998, Molecular membrane biology.