Effects of image noise, respiratory motion, and motion compensation on 3D activity quantification in count-limited PET images

The aims of this study were to evaluate the effects of noise, motion blur, and motion compensation using quiescent-period gating (QPG) on the activity concentration (AC) distribution-quantified using the cumulative AC volume histogram (ACVH)-in count-limited studies such as 90Y-PET/CT. An International Electrotechnical Commission phantom filled with low 18F activity was used to simulate clinical 90Y-PET images. PET data were acquired using a GE-D690 when the phantom was static and subject to 1-4 cm periodic 1D motion. The static data were down-sampled into shorter durations to determine the effect of noise on ACVH. Motion-degraded PET data were sorted into multiple gates to assess the effect of motion and QPG on ACVH. Errors in ACVH at AC90 (minimum AC that covers 90% of the volume of interest (VOI)), AC80, and ACmean (average AC in the VOI) were characterized as a function of noise and amplitude before and after QPG. Scan-time reduction increased the apparent non-uniformity of sphere doses and the dispersion of ACVH. These effects were more pronounced in smaller spheres. Noise-related errors in ACVH at AC20 to AC70 were smaller (<15%) compared to the errors between AC80 to AC90 (>15%). The accuracy of ACmean was largely independent of the total count. Motion decreased the observed AC and skewed the ACVH toward lower values; the severity of this effect depended on motion amplitude and tumor diameter. The errors in AC20 to AC80 for the 17 mm sphere were  -25% and  -55% for motion amplitudes of 2 cm and 4 cm, respectively. With QPG, the errors in AC20 to AC80 of the 17 mm sphere were reduced to  -15% for motion amplitudes  <4 cm. For spheres with motion amplitude to diameter ratio  >0.5, QPG was effective at reducing errors in ACVH despite increases in image non-uniformity due to increased noise. ACVH is believed to be more relevant than mean or maximum AC to calculate tumor control and normal tissue complication probability. However, caution needs to be exercised when using ACVH in post-therapy 90Y imaging because of its susceptibility to image degradation from both image noise and respiratory motion.

[1]  C. Ling,et al.  Effect of respiratory gating on quantifying PET images of lung cancer. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  F. Orsi,et al.  Radioembolization of Hepatic Lesions from a Radiobiology and Dosimetric Perspective , 2014, Front. Oncol..

[3]  D. Townsend,et al.  Post-radioembolization yttrium-90 PET/CT - part 2: dose-response and tumor predictive dosimetry for resin microspheres , 2013, EJNMMI Research.

[4]  Yuni K Dewaraja,et al.  131I-Tositumomab Radioimmunotherapy: Initial Tumor Dose–Response Results Using 3-Dimensional Dosimetry Including Radiobiologic Modeling , 2010, Journal of Nuclear Medicine.

[5]  M. D’Arienzo,et al.  90Y PET-based dosimetry after selective internal radiotherapy treatments , 2012, Nuclear medicine communications.

[6]  R. Coleman,et al.  Single photon emission computed tomography and positron emission tomography in cancer imaging. , 1991, Cancer.

[7]  S. Kappadath,et al.  Comparing voxel-based absorbed dosimetry methods in tumors, liver, lung, and at the liver-lung interface for 90Y microsphere selective internal radiation therapy , 2015, EJNMMI Physics.

[8]  G M Megson,et al.  Comparison of Techniques , 1999 .

[9]  Yan Rolland,et al.  Clinical Feasibility of Fast 3-Dimensional Dosimetry of the Liver for Treatment Planning of Hepatocellular Carcinoma with 90Y-Microspheres , 2011, The Journal of Nuclear Medicine.

[10]  C Ross Schmidtlein,et al.  Assessing and accounting for the impact of respiratory motion on FDG uptake and viable volume for liver lesions in free-breathing PET using respiration-suspended PET images as reference. , 2014, Medical physics.

[11]  Yuni K. Dewaraja,et al.  MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy , 2012, The Journal of Nuclear Medicine.

[12]  Ravinder Nath,et al.  AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137. , 2009, Medical physics.

[13]  George Starkschall,et al.  A novel platform simulating irregular motion to enhance assessment of respiration‐correlated radiation therapy procedures , 2005, Journal of applied clinical medical physics.

[14]  Otto Muzik,et al.  Early dose response to yttrium-90 microsphere treatment of metastatic liver cancer by a patient-specific method using single photon emission computed tomography and positron emission tomography. , 2009, International journal of radiation oncology, biology, physics.

[15]  A. Pasciak,et al.  A Comparison of Techniques for 90Y PET/CT Image-Based Dosimetry Following Radioembolization with Resin Microspheres , 2014, Front. Oncol..

[16]  S. Jalkanen,et al.  Nuclear imaging of inflammation: homing-associated molecules as targets , 2013, EJNMMI Research.

[17]  Michael Tapner,et al.  A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres , 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[18]  Kenneth G. Thurston,et al.  Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: Technical and methodologic considerations. , 2006, Journal of vascular and interventional radiology : JVIR.

[19]  George Sgouros,et al.  Dosimetry of internal emitters. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  E. Frey,et al.  Development and evaluation of convergent and accelerated penalized SPECT image reconstruction methods for improved dose-volume histogram estimation in radiopharmaceutical therapy. , 2014, Medical physics.

[21]  Marnix G. E. H. Lam,et al.  Quantitative Comparison of PET and Bremsstrahlung SPECT for Imaging the In Vivo Yttrium-90 Microsphere Distribution after Liver Radioembolization , 2013, PloS one.

[22]  D. Townsend,et al.  Post-radioembolization yttrium-90 PET/CT - part 1: diagnostic reporting , 2013, EJNMMI Research.

[23]  V. Bettinardi,et al.  Number of partitions (gates) needed to obtain motion-free images in a respiratory gated 4D-PET/CT study as a function of the lesion size and motion displacement. , 2009, Medical physics.

[24]  T. Pan,et al.  Factors affecting quantification in PET/CT imaging , 2008 .

[25]  Kris Thielemans,et al.  Quiescent period respiratory gating for PET/CT. , 2010, Medical physics.

[26]  S. Nehmeh,et al.  Respiratory motion in positron emission tomography/computed tomography: a review. , 2008, Seminars in nuclear medicine.

[27]  S. Kappadath,et al.  Selective Internal Radiation Therapy With Yttrium-90 Glass Microspheres: Biases and Uncertainties in Absorbed Dose Calculations Between Clinical Dosimetry Models. , 2016, International journal of radiation oncology, biology, physics.

[28]  W. Butler,et al.  AAPM Recommendations on Dose Prescription and Reporting Methods for Permanent Interstitial Brachytherapy for Prostate Cancer Report of AAPMTask Group , 2009 .

[29]  C. Bodet-Milin,et al.  Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT , 2013, EJNMMI Research.

[30]  Anna Celler,et al.  Comparison of internal dose estimates obtained using organ-level, voxel S value, and Monte Carlo techniques. , 2014, Medical physics.

[31]  F. Mourtada,et al.  Evaluation of a deterministic grid-based Boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine , 2016, Physics in medicine and biology.

[32]  S. Kappadath,et al.  Practical reconstruction protocol for quantitative (90)Y bremsstrahlung SPECT/CT. , 2016, Medical physics.

[33]  John W. Clark,et al.  A motion-incorporated reconstruction method for gated PET studies , 2006, Physics in medicine and biology.

[34]  Cedric X. Yu,et al.  Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma. , 2004, Medical physics.

[35]  S. Hapdey,et al.  Management of respiratory motion in PET/computed tomography: the state of the art , 2014, Nuclear medicine communications.

[36]  R Mohan,et al.  Dose-volume histograms. , 1991, International journal of radiation oncology, biology, physics.

[37]  G. Sgouros,et al.  Dosimetry for radiopharmaceutical therapy. , 2014, Seminars in nuclear medicine.

[38]  Kathy Willowson,et al.  Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging , 2014, PloS one.

[39]  Kenneth G. Thurston,et al.  Yttrium-90 microspheres: radiation therapy for unresectable liver cancer. , 2002, Journal of vascular and interventional radiology : JVIR.

[40]  E. Frey,et al.  Improved dose–volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters , 2013, Physics in medicine and biology.

[41]  D. Bailey,et al.  Quantitative (90)Y image reconstruction in PET. , 2012, Medical physics.

[42]  Renaud Lhommel,et al.  Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[43]  Habib Zaidi,et al.  The effect of breathing irregularities on quantitative accuracy of respiratory gated PET∕CT. , 2011, Medical physics.

[44]  Jennifer Prekeges.  Nuclear Medicine Instrumentation , 2009 .

[45]  Bradley T. Christian,et al.  Quantitative PET with positron emitters that emit prompt gamma rays , 1995, IEEE Trans. Medical Imaging.

[46]  L A DeWerd,et al.  A new internal pair production branching ratio of 90Y: the development of a non-destructive assay for 90Y and 90Sr. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[47]  D. Low,et al.  A comparison between amplitude sorting and phase-angle sorting using external respiratory measurement for 4D CT. , 2006, Medical physics.

[48]  D. Franck,et al.  Three-Dimensional Personalized Monte Carlo Dosimetry in 90Y Resin Microspheres Therapy of Hepatic Metastases: Nontumoral Liver and Lungs Radiation Protection Considerations and Treatment Planning Optimization , 2014, The Journal of Nuclear Medicine.

[49]  J. Bouček,et al.  A Gelatin Liver Phantom of Suspended 90Y Resin Microspheres to Simulate the Physiologic Microsphere Biodistribution of a Postradioembolization Liver , 2014, The Journal of Nuclear Medicine Technology.

[50]  S. Nehmeh,et al.  Respiratory Motion Correction Strategies in Thoracic PET-CT Imaging. , 2013, PET clinics.

[51]  Michael Ljungberg,et al.  Development and evaluation of an improved quantitative (90)Y bremsstrahlung SPECT method. , 2012, Medical physics.

[52]  A. Pevsner,et al.  Quantitation of respiratory motion during 4D-PET/CT acquisition. , 2004, Medical physics.