Dermatophytes: host-pathogen interaction and antifungal resistance.

Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance.

[1]  D. E. Gras,et al.  Transcriptional profiling reveals genes in the human pathogen Trichophyton rubrum that are expressed in response to pH signaling. , 2010, Microbial pathogenesis.

[2]  D. E. Gras,et al.  Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum , 2010, BMC Microbiology.

[3]  V. Silva,et al.  Onychomycosis in São Paulo, Brazil , 2009, Mycopathologia.

[4]  N. Martinez-Rossi,et al.  Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. , 2009, Journal of medical microbiology.

[5]  N. Leite,et al.  [Feet dermatophytosis in soccer players]. , 2009, Anais brasileiros de dermatologia.

[6]  T. Liu,et al.  Expression dynamics of secreted protease genes in Trichophyton rubrum induced by key host's proteinaceous components. , 2009, Medical mycology.

[7]  Jérôme Thomas,et al.  Gene Expression Profiling in the Human Pathogenic Dermatophyte Trichophyton rubrum during Growth on Proteins , 2008, Eukaryotic Cell.

[8]  B. Losson,et al.  Secreted dipeptidyl peptidases as potential virulence factors for Microsporum canis. , 2008, FEMS immunology and medical microbiology.

[9]  B. Losson,et al.  Secreted subtilisins of Microsporum canis are involved in adherence of arthroconidia to feline corneocytes. , 2008, Journal of medical microbiology.

[10]  T. C. White,et al.  Generating and Testing Molecular Hypotheses in the Dermatophytes , 2008, Eukaryotic Cell.

[11]  N. Peres,et al.  Antifungal Resistance Mechanisms in Dermatophytes , 2008, Mycopathologia.

[12]  Aditya K. Gupta,et al.  Update in Antifungal Therapy of Dermatophytosis , 2008, Mycopathologia.

[13]  H. Degreef Clinical Forms of Dermatophytosis (Ringworm Infection) , 2008, Mycopathologia.

[14]  J. Bouchara,et al.  Updates on the Epidemiology of Dermatophyte Infections , 2008, Mycopathologia.

[15]  B. Losson,et al.  Pathogenesis of Dermatophytosis , 2008, Mycopathologia.

[16]  R. Aly,et al.  The prevalence of dermatophyte infection in patients infected with human immunodeficiency virus , 2008, International journal of dermatology.

[17]  F. Segato,et al.  Over-expression of genes coding for proline oxidase, riboflavin kinase, cytochrome c oxidase and an MFS transporter induced by acriflavin in Trichophyton rubrum. , 2008, Medical mycology.

[18]  T. Liu,et al.  Global gene expression of Trichophyton rubrum in response to PH11B, a novel fatty acid synthase inhibitor , 2007, Journal of applied microbiology.

[19]  N. Martinez-Rossi,et al.  Isolation of transcripts over-expressed in human pathogen Trichophyton rubrum during growth in keratin. , 2007, Microbial pathogenesis.

[20]  A. Hasegawa,et al.  The effect of dermatophytes on cytokine production by human keratinocytes , 2007, Archives of Dermatological Research.

[21]  F. Segato,et al.  Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs. , 2007, FEMS microbiology letters.

[22]  O. Boulat,et al.  Sulphite efflux pumps in Aspergillus fumigatus and dermatophytes. , 2007, Microbiology.

[23]  B. Horwitz,et al.  Infection stages of the dermatophyte pathogen Trichophyton: microscopic characterization and proteolytic enzymes. , 2007, Medical mycology.

[24]  A. Gaedigk,et al.  Tracking Trichophyton tonsurans Through a Large Urban Child Care Center: Defining Infection Prevalence and Transmission Patterns by Molecular Strain Typing , 2006, Pediatrics.

[25]  H. Silveira,et al.  The pH signaling transcription factor PacC mediates the growth of Trichophyton rubrum on human nail in vitro. , 2006, Medical mycology.

[26]  S. Ikeda,et al.  Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections. , 2006, Journal of medical microbiology.

[27]  W. Maccheroni,et al.  Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. , 2006, Journal of medical microbiology.

[28]  O. Fischman,et al.  Incidence of Tinea capitis in São Paulo, Brazil , 2006, Mycopathologia.

[29]  D. Perlin,et al.  A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus , 2006, Antimicrobial Agents and Chemotherapy.

[30]  E. R. Siqueira,et al.  [Occurrence of dermatophyte, in nails, feet and hands of university students]. , 2006, Revista da Sociedade Brasileira de Medicina Tropical.

[31]  N. Martinez-Rossi,et al.  Molecular cloning and characterization of a novel ABC transporter gene in the human pathogen Trichophyton rubrum. , 2006, Medical mycology.

[32]  D. Parry,et al.  The three-dimensional structure of trichocyte (hard alpha-) keratin intermediate filaments: features of the molecular packing deduced from the sites of induced crosslinks. , 2005, Journal of structural biology.

[33]  R. Cordeiro,et al.  Onychomycosis in Ceará (Northeast Brazil): epidemiological and laboratory aspects. , 2005, Memorias do Instituto Oswaldo Cruz.

[34]  W. de Souza,et al.  The influence of surface carbohydrates during in vitro infection of mammalian cells by the dermatophyte Trichophyton rubrum. , 2004, Research in microbiology.

[35]  R. Prade,et al.  Molecular aspects of dermatophyte-host interactions. , 2004 .

[36]  G Molenberghs,et al.  High prevalence of foot diseases in Europe: results of the Achilles Project , 2003, Mycoses.

[37]  W. de Souza,et al.  The role of surface carbohydrates on the interaction of microconidia of Trichophyton mentagrophytes with epithelial cells. , 2003, FEMS immunology and medical microbiology.

[38]  M. Ghannoum,et al.  Clinical Trichophyton rubrum Strain Exhibiting Primary Resistance to Terbinafine , 2003, Antimicrobial Agents and Chemotherapy.

[39]  M. Monod,et al.  Secreted Metalloprotease Gene Family of Microsporum canis , 2002, Infection and Immunity.

[40]  P. Sohnle,et al.  Dermatophytes and host defence in cutaneous mycoses. , 1998, Medical mycology.

[41]  A. H. Aubaid,et al.  Extracellular enzyme activities of dermatophytes and yeast isolates on solid media , 1997, Mycoses.

[42]  P. Sohnle,et al.  Cutaneous defenses against dermatophytes and yeasts , 1995, Clinical microbiology reviews.

[43]  R. Nelson,et al.  An immunoinhibitory cell wall glycoprotein (mannan) from Trichophyton rubrum. , 1991, The Journal of investigative dermatology.

[44]  K. Takamori,et al.  Isolation of a keratinolytic proteinase from Trichophyton mentagrophytes with enzymatic activity at acidic pH , 1989, Infection and immunity.

[45]  D. Stevens,et al.  Steroid metabolism as a mechanism of escape from progesterone-mediated growth inhibition in Trichophyton mentagrophytes. , 1989, The Journal of biological chemistry.