Multifibre Application in Laser-Induced Interstitial Thermotherapy under On-Line MR Control

Abstract.The application of multiple fibres for the conformal irradiation of tumours by laser-induced interstitial thermotherapy (LITT) has been investigated. A study was performed to evaluate the coagulated zones produced in porcine muscle tissue in vitro. For delivering specified powers into the tissue, a multifibre system was developed which allows the simultaneous use of up to four fibres. A new quantitative method of magnetic resonance imaging (MRI) has been applied for real-time thermometry. It is based on the temperature dependence of the T1 relaxation time and the equilibrium magnetisation. The MR results were compared with the measurements of fibreoptic thermometers. Since the acquisition time of the selected MR sequence takes only 3 s per slice and the calculation of the temperature measurement could be realised within a few seconds, the temperature mapping works closely to real time. The accuracy of the temperature measurements in muscle tissue was 1.5°C. Whereas single-fibre applications induced convex-shaped isotherms, concave structures were generated by a multifibre LITT.

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