Histological analysis of calcium phosphate bone grafts for surgically created periodontal bone defects in dogs.

A calcium phosphate cement (CPC-1), prepared by mixing an equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous with water, has been shown to be highly biocompatible and osteoconductive. A new type of calcium phosphate cement (CPC-2), prepared by mixing a mixture of alpha-tricalcium phosphate and calcium carbonate with pH 7.4 sodium phosphate solution, was also reported to be highly biocompatible. The objective of the present study was to compare the osteoconductivities of CPC-1 and CPC-2 when implanted in surgically created defects in the jaw bones of dogs. At 1 month after surgery, implanted CPC-1 was partially replaced by new bone and converted to bone within 6 months. In comparison, at 1 month after surgery, the defect filled with CPC-2 was mostly replaced by new bone. Therefore, bone formation in CPC-2-filled pocket was more rapid than in CPC-1-filled pocket. These findings supported the hypothesis that CPC-2 converted to bone more rapidly than CPC-1.

[1]  Masao,et al.  Characteristics of Human Alveolar Bone Derived Cells , 2010 .

[2]  J. Aubin,et al.  Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations , 1986, Calcified Tissue International.

[3]  J. Termine,et al.  Vibrational spectra of some phosphate salts amorphous to X-ray diffraction , 1974, Calcified Tissue Research.

[4]  S. Murai,et al.  Histopathological and cell enzyme studies of calcium phosphate cements. , 2004, Dental materials journal.

[5]  S. Takagi,et al.  Premixed calcium-phosphate cement pastes. , 2003, Journal of biomedical materials research. Part B, Applied biomaterials.

[6]  S. Murai,et al.  Fluorescent labeling analysis and electron probe microanalysis for alveolar ridge augmentation using calcium phosphate cement. , 2002, Dental materials journal.

[7]  S. Murai,et al.  Histopathologic reaction of a calcium phosphate cement for alveolar ridge augmentation. , 2002, Journal of biomedical materials research.

[8]  S. Takagi,et al.  Formation of macropores in calcium phosphate cement implants , 2001, Journal of materials science. Materials in medicine.

[9]  C. Friedman,et al.  Morphological and phase characterizations of retrieved calcium phosphate cement implants. , 2001, Journal of biomedical materials research.

[10]  S. Takagi,et al.  Diametral tensile strength and compressive strength of a calcium phosphate cement: effect of applied pressure. , 2000, Journal of biomedical materials research.

[11]  K. Ishikawa,et al.  Formation of hydroxyapatite in new calcium phosphate cements. , 1998, Biomaterials.

[12]  S. Murai,et al.  Histopathological reaction of calcium phosphate cement in periodontal bone defect. , 1995, Dental materials journal.

[13]  K. Asaoka,et al.  Behavior of a calcium phosphate cement in simulated blood plasma in vitro. , 1994, Dental materials : official publication of the Academy of Dental Materials.

[14]  I. Moro,et al.  Histopathological reactions of calcium phosphate cement. , 1992, Dental materials journal.

[15]  R Z LeGeros,et al.  Calcium phosphates in oral biology and medicine. , 1991, Monographs in oral science.

[16]  K. Otsuka,et al.  Mineralized bone nodule formation in vitro by cell populations from young adult rabbit alveolar bone. , 1989, Shika Kiso Igakkai zasshi = Japanese journal of oral biology.

[17]  A. Sasaki.  [On octacalcium phosphate]. , 1965, Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan.