An evaluation of structural and functional prefrontal deficits in schizophrenia: MRI and neuropsychological measures

Magnetic resonance imaging was used to assess prefrontal brain structure in 17 schizophrenic, 18 psychiatric control, and 19 normal control subjects of comparable age, social background, and educational status, while three neuropsychological measures were used to assess prefrontal functioning. Schizophrenic patients had significantly smaller prefrontal areas than both psychiatric control and normal control subjects in all three planes. When posterior brain area and temporal lobe were entered into statistical analysis as covariates, they did not explain the prefrontal deficits. Schizophrenic patients made more perseveration errors on the Wisconsin Card Sorting Task and had fewer correct responses on the Spatial Delayed Response Task than normal control subjects. Schizophrenic patients performed more poorly than psychiatric control subjects on the Block Design Test. No group differences were found on three other nonfrontal tasks. These data lend some support to the role of prefrontal deficits in the development of schizophrenia.

[1]  H. Kaiya,et al.  Midsagittal cortical pathomorphology of schizophrenia: A magnetic resonance imaging study , 1989, Psychiatry Research.

[2]  R. Priest.  Measurement and Classification of Psychiatric Symptoms , 1975 .

[3]  S. Mednick,et al.  The Copenhagen High-Risk Project, 1962-86. , 1987, Schizophrenia bulletin.

[4]  Arthur L. Benton,et al.  Differential behavioral effects in frontal lobe disease , 1968 .

[5]  D. Weinberger,et al.  Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. , 1988, Archives of general psychiatry.

[6]  Great Britain. Foreign Office.,et al.  Classification of occupations , 1960 .

[7]  Clemens S. Bernhardson,et al.  375: Type I Error Rates When Multiple Comparison Procedures Follow a Significant F Test of ANOVA , 1975 .

[8]  N C Andreasen,et al.  Negative v positive schizophrenia. Definition and validation. , 1982, Archives of general psychiatry.

[9]  J. Graham Beaumont.  Introduction to Neuropsychology , 1989 .

[10]  Morton B. Brown,et al.  372: The Anova and Multiple Comparisons for Data with Heterogeneous Variances , 1974 .

[11]  Rand R. Wilcox,et al.  New Statistical Procedures for the Social Sciences: Modern Solutions To Basic Problems , 1987 .

[12]  J. Ehrhardt,et al.  Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. , 1990, Archives of general psychiatry.

[13]  M S Buchsbaum,et al.  Simultaneous cerebral glucography with positron emission tomography and topographic electroencephalography. , 1984, Progress in brain research.

[14]  H. Hendrie,et al.  Magnetic resonance brain images in schizophrenic and normal subjects: influence of diagnosis and education. , 1988, Schizophrenia bulletin.

[15]  A. Raine,et al.  Interhemispheric transfer in schizophrenics, depressives, and normals with schizoid tendencies. , 1989 .

[16]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[17]  D. Weinberger,et al.  Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism. , 1988, Archives of general psychiatry.

[18]  J. Kelsoe,et al.  Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study. , 1988, Archives of general psychiatry.

[19]  J. Kelsoe,et al.  Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. , 1989, The American journal of psychiatry.

[20]  H. Nelson.  A Modified Card Sorting Test Sensitive to Frontal Lobe Defects , 1976, Cortex.

[21]  J. Ehrhardt,et al.  Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study. , 1986, Archives of general psychiatry.

[22]  A. Young,et al.  A Magnetic Resonance Imaging Study of Schizophrenia: Brain Structure and Clinical Symptoms , 1991, British Journal of Psychiatry.

[23]  P F Liddle,et al.  Schizophrenic Syndromes and Frontal Lobe Performance , 1991, British Journal of Psychiatry.

[24]  D. Weinberger,et al.  Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. , 1986, Archives of general psychiatry.

[25]  Elizabeth K. Warrington,et al.  The WAIS as a lateralizing and localizing diagnostic instrument: A study of 656 patients with unilateral cerebral lesions , 1986, Neuropsychologia.

[26]  A. Raine,et al.  Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls: A magnetic resonance imaging and neuropsychological evaluation. , 1990 .

[27]  D. Weinberger.  Implications of normal brain development for the pathogenesis of schizophrenia. , 1987, Archives of general psychiatry.