Syddansk Universitet The APOE e4 allele is associated with a reduction in FEV1/FVC in women A cross-sectional analysis of the long life family study

[1]  National Institute for Occupational Safety and Health Spirometry Training Program. , 2018 .

[2]  Cleo C. van Diemen,et al.  Genome‐wide association study on the FEV1/FVC ratio in never‐smokers identifies HHIP and FAM13A , 2017, The Journal of allergy and clinical immunology.

[3]  S. Levine,et al.  Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease. , 2016, American journal of respiratory cell and molecular biology.

[4]  H. Coxson,et al.  Chronic Hypoxia Accentuates Dysanaptic Lung Growth. , 2016, American journal of respiratory and critical care medicine.

[5]  I. Borecki,et al.  Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology , 2016, Journal of the American Geriatrics Society.

[6]  Paul M. Thompson,et al.  Age, APOE and sex: Triad of risk of Alzheimer’s disease , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[7]  A. Gow,et al.  Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis. , 2016, American journal of respiratory cell and molecular biology.

[8]  Lorna M. Lopez,et al.  Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation , 2015, Nature Communications.

[9]  L. Wain,et al.  Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank , 2015, The Lancet. Respiratory medicine.

[10]  Ling Lin,et al.  Apolipoprotein E deficiency and high-fat diet cooperate to trigger lipidosis and inflammation in the lung via the toll-like receptor 4 pathway , 2015, Molecular medicine reports.

[11]  J. Moss,et al.  Serum apolipoprotein A-I and large high-density lipoprotein particles are positively correlated with FEV1 in atopic asthma. , 2015, American journal of respiratory and critical care medicine.

[12]  L. Christiansen,et al.  Genetic variants associated with lung function: the long life family study , 2014, Respiratory Research.

[13]  P. Blackshear,et al.  APOε4 is associated with enhanced in vivo innate immune responses in human subjects. , 2014, The Journal of allergy and clinical immunology.

[14]  J. Madenspacher,et al.  Apolipoprotein E-Deficient Mice Are Susceptible to the Development of Acute Lung Injury , 2014, Respiration.

[15]  S. Pacheco,et al.  Dysanaptic growth of lung and airway in children with post‐infectious bronchiolitis obliterans , 2014, The clinical respiratory journal.

[16]  A. Yashin,et al.  Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan , 2014, PLoS genetics.

[17]  R. Mayeux,et al.  Apolipoprotein E and familial longevity , 2013, Neurobiology of Aging.

[18]  A. Yashin,et al.  The role of lipid‐related genes, aging‐related processes, and environment in healthspan , 2013, Aging cell.

[19]  M. Vitek,et al.  Apolipoproteins and Apolipoprotein Mimetic Peptides Modulate Phagocyte Trafficking through Chemotactic Activity* , 2012, The Journal of Biological Chemistry.

[20]  S. Stanojevic,et al.  Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations , 2012, European Respiratory Journal.

[21]  J. D’Armiento,et al.  Activation of the TLR4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[22]  D. Massaro,et al.  Developmental Alveologenesis: New Roles for ApoE and LDL Receptor , 2011, Pediatric Research.

[23]  Lorna M. Lopez,et al.  Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function , 2011, Nature Genetics.

[24]  C. Colton,et al.  Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A , 2011, The Journal of Immunology.

[25]  Paola Sebastiani,et al.  Health and function of participants in the Long Life Family Study: A comparison with other cohorts , 2011, Aging.

[26]  N. Raghavachari,et al.  Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway. , 2010, American journal of respiratory and critical care medicine.

[27]  I. Rahman,et al.  Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD , 2010, Journal of Inflammation.

[28]  C. Hersh.  Faculty Opinions recommendation of Genome-wide association study identifies five loci associated with lung function. , 2010 .

[29]  A. Yashin,et al.  “Predicting” parental longevity from offspring endophenotypes: Data from the Long Life Family Study (LLFS) , 2010, Mechanisms of Ageing and Development.

[30]  F. Theissig,et al.  ApoE-deficient mice on cholate-containing high-fat diet reveal a pathology similar to lung sarcoidosis. , 2010, The American journal of pathology.

[31]  C. Finch.  Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition , 2009, Proceedings of the National Academy of Sciences.

[32]  Laura Fratiglioni,et al.  APOE-related mortality: Effect of dementia, cardiovascular disease and gender , 2009, Neurobiology of Aging.

[33]  Guojun Bu,et al.  Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy , 2009, Nature Reviews Neuroscience.

[34]  A. Boulares,et al.  HIGH FAT DIET INDUCES LUNG REMODELING IN APOE DEFICIENT MICE: AN ASSOCIATION WITH AN INCREASE IN CIRCULATORY AND LUNG INFLAMMATORY FACTORS , 2009, Laboratory Investigation.

[35]  G. Kolovou,et al.  Apolipoprotein E gene polymorphism and gender. , 2009, Annals of clinical and laboratory science.

[36]  Scott T. Weiss,et al.  A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study , 2009, PLoS genetics.

[37]  Nicklas Raun Jacobsen,et al.  Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice , 2009, Particle and Fibre Toxicology.

[38]  D. Massaro,et al.  Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[39]  G. Hansmann,et al.  An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. , 2008, The Journal of clinical investigation.

[40]  H. Gérard,et al.  Apolipoprotein E4 enhances attachment of Chlamydophila (Chlamydia) pneumoniae elementary bodies to host cells. , 2008, Microbial pathogenesis.

[41]  P. Mortensen,et al.  The Danish Civil Registration System. A cohort of eight million persons. , 2006, Danish medical bulletin.

[42]  K. Weisgraber,et al.  Apolipoprotein E structure: insights into function. , 2006, Trends in biochemical sciences.

[43]  H. Melbye,et al.  Lung function testing in the elderly--can we still use FEV1/FVC<70% as a criterion of COPD? , 2006, Respiratory medicine.

[44]  Jiwang Chen,et al.  Alveolar type I cells protect rat lung epithelium from oxidative injury , 2006, The Journal of physiology.

[45]  J. Hankinson,et al.  Interpretative strategies for lung function tests , 2005, European Respiratory Journal.

[46]  F. Sacks,et al.  Apolipoprotein-mediated pathways of lipid antigen presentation , 2005, Nature.

[47]  J. Hankinson,et al.  Standardisation of spirometry , 2005, European Respiratory Journal.

[48]  T. Murohara,et al.  Preventive cardiology: abstractAssociation of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors , 2004 .

[49]  B. Celli,et al.  Population impact of different definitions of airway obstruction , 2003, European Respiratory Journal.

[50]  A. Gulsvik,et al.  Epidemiological aspects and early detection of chronic obstructive airway diseases in the elderly , 2003, European Respiratory Journal.

[51]  A. Ryan,et al.  Maternal loading with very low-density lipoproteins stimulates fetal surfactant synthesis. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[52]  T. V. van Berkel,et al.  Apolipoprotein E Protects Against Bacterial Lipopolysaccharide-induced Lethality , 2001, The Journal of Biological Chemistry.

[53]  J. Kuiper,et al.  Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo. , 1997, The Journal of clinical investigation.

[54]  Jonathan D. Smith,et al.  Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides , 1996, Nature Genetics.

[55]  H. V. van Houwelingen,et al.  Growth of airways and air spaces in teenagers is related to sex but not to symptoms. , 1993, Journal of applied physiology.

[56]  J. Ordovás,et al.  Familial apolipoprotein E deficiency. , 1986, The Journal of clinical investigation.

[57]  L. Chan,et al.  Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues. , 1986, The Journal of clinical investigation.

[58]  Z. Werb,et al.  Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages , 1984, Journal of Experimental Medicine.

[59]  R. Levy,et al.  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.

[60]  M. Province,et al.  The Long Life Family Study (LLFS) , 2019, Encyclopedia of Gerontology and Population Aging.

[61]  A. Yashin,et al.  Age , gender , and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E 4 allele on lifespan , 2015 .

[62]  Elizabeth Anderson,et al.  Genome-wide association study of lung function phenotypes in a founder population. , 2014, The Journal of allergy and clinical immunology.

[63]  J. D’Armiento,et al.  Activation of the TLR 4 signaling pathway and abnormal cholesterol efflux lead to emphysema in ApoE-deficient mice , 2012 .

[64]  A. Kennerley,et al.  Cardiovascular , Pulmonary , and Renal Pathology Paigen Diet – Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1 – Dependent Manner , 2011 .

[65]  A. Hofman,et al.  Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function , 2010, Nature Genetics.

[66]  Ahmad Y. Sheikh,et al.  Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. , 2007, Circulation.

[67]  P. Sebastiani,et al.  American Journal of Epidemiology Practice of Epidemiology a Family Longevity Selection Score: Ranking Sibships by Their Longevity, Size, and Availability for Study , 2022 .