The alteration of ferritin and transferrin saturation under body mass index and blood pressure in first-time and regular male blood donors in Taiwan

Abstract Iron status, body mass index (BMI) and blood pressure (BP) are all important health indicators. In this study, ferritin and transferrin saturation levels and their correlations with BMI and BP were investigated in first-time and regular male blood donors in Taiwan. Serum ferritin and transferrin saturation values represented iron status of blood donors. Serum ferritin, serum iron, and total iron binding capacity (TIBC) were determined by chemiluminescent immunoassay sandwich method, timed-endpoint method, and turbidimetric method, respectively. Transferrin saturation was calculated as 100× serum iron/TIBC. Statistical analyses included 2-sample t test, chi-square test, Pearson correlation coefficient, and multiple linear regression. Comparisons of ferritin and transferrin saturation mean values with BMI, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), and occupation were conducted. A total of 111 first-time donors and 1249 regular blood donors participated in this study. The ferritin and transferrin saturation mean values of regular male blood donors were lower than those of first-time male blood donors, but remained within the safe range. BMI was positively correlated with serum log ferritin, but not with transferrin saturation value in first-time and regular blood donors. First-time donors with BMI ≥24 kg/m2 and aged more than 40 years demonstrated 1.37-fold higher serum ferritin on average. Among regular donors, significant effects of BMI ≥24 kg/m2 and age >40 years were observed with 1.25- and 1.18-fold higher serum ferritin levels, respectively. First-time donors with SBP ≥120/DBP ≥80, ≥120/<80, and <120/≥80 mm Hg had on average 1.65-, 1.54-, and 2.59-fold higher serum ferritin levels than those with normal BP. Ferritin level was higher in BMI ≥24 kg/m2 subgroup than in BMI <24 kg/m2 subgroup among first time and regular male donors, but no difference was found in transferrin saturation values. Abnormal SBP/DBP was associated with increased ferritin level only in first-time male blood donors.

[1]  J. Moreno-Navarrete,et al.  Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression , 2018, The Journal of clinical endocrinology and metabolism.

[2]  P. Kraml,et al.  Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process. , 2018, Atherosclerosis.

[3]  W. D. de Kort,et al.  Associations of health status with subsequent blood donor behavior—An alternative perspective on the Healthy Donor Effect from Donor InSight , 2017, PloS one.

[4]  S. O’Brien,et al.  A large national study of ferritin testing in Canadian blood donors , 2017, Transfusion.

[5]  R. Djoudi,et al.  International forum: an investigation of iron status in blood donors. , 2017, Blood transfusion = Trasfusione del sangue.

[6]  Abidullah Khan,et al.  Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People , 2016, Journal of obesity.

[7]  D. Crawford,et al.  Iron and non-alcoholic fatty liver disease , 2016, World journal of gastroenterology.

[8]  F. Carrasco,et al.  Micronutrient Deficiencies in Morbidly Obese Women Prior to Bariatric Surgery , 2016, Obesity Surgery.

[9]  F. Wang,et al.  Obesity and iron deficiency: a quantitative meta‐analysis , 2015, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[10]  S. Lattimore,et al.  Blood donors in England and North Wales: demography and patterns of donation , 2015, Transfusion.

[11]  M. Shuchman.  Frequent blood donors risk iron deficiency , 2014, Canadian Medical Association Journal.

[12]  G. Tarantino,et al.  Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease? , 2014, World journal of gastroenterology.

[13]  Libin Liu,et al.  Study of the correlation between serum ferritin levels and the aggregation of metabolic disorders in non-diabetic elderly patients , 2014, Experimental and therapeutic medicine.

[14]  I. Veldhuizen,et al.  Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return. , 2014, Blood transfusion = Trasfusione del sangue.

[15]  S. Glynn,et al.  Iron deficiency in blood donors: the REDS‐II Donor Iron Status Evaluation (RISE) study , 2012, Transfusion.

[16]  Hoi Lun Cheng,et al.  The relationship between obesity and hypoferraemia in adults: a systematic review , 2012, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[17]  A. Buser,et al.  The value of routine ferritin measurement in blood donors , 2010, Transfusion.

[18]  B. Bacon,et al.  Diagnosis and Management of Hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases , 2011, Hepatology.

[19]  D. Swinkels,et al.  Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. , 2009, The Journal of clinical endocrinology and metabolism.

[20]  S. Katz,et al.  Iron Stores and Vascular Function in Voluntary Blood Donors , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[21]  J. Halterman,et al.  Overweight children and adolescents: a risk group for iron deficiency. , 2004, Pediatrics.

[22]  M. Yılmaz,et al.  Increased oxidative stress and hypozincemia in male obesity. , 2002, Clinical biochemistry.

[23]  R. Dover,et al.  Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? , 2001, BMJ : British Medical Journal.

[24]  A. Tavill.  Diagnosis and management of hemochromatosis , 2001, Hepatology.