Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications

We propose and characterize oil-in-gelatin dispersions that approximate the dispersive dielectric properties of a variety of human soft tissues over the microwave frequency range from 500 MHz to 20 GHz. Different tissues are mimicked by selection of an appropriate concentration of oil. The materials possess long-term stability and can be employed in heterogeneous configurations without change in geometry or dielectric properties due to osmotic effects. Thus, these materials can be used to construct heterogeneous phantoms, including anthropomorphic types, for narrowband and ultrawideband microwave technologies, such as breast cancer detection and imaging systems.

[1]  A. W. Guy,et al.  Analyses of Electromagnetic Fields Induced in Biological Tissues by Thermographic Studies on Equivalent Phantom Models , 1971 .

[2]  D. Koopman,et al.  Experimental Development of Simulated Biomaterials for Dosimetry Studies of Hazardous Microwave Radiation (Short Papers) , 1976 .

[3]  P L Carson,et al.  Anthropomorphic breast phantoms for assessing ultrasonic imaging system performance and for training ultrasonographers: Part I , 1982, Journal of clinical ultrasound : JCU.

[4]  T. W. Athey,et al.  Measurement of Radio Frequency Permittivity of Biological Tissues with an Open-Ended Coaxial Line: Part II - Experimental Results , 1982 .

[5]  E L Madsen,et al.  Oil-in-gelatin dispersions for use as ultrasonically tissue-mimicking materials. , 1982, Ultrasound in medicine & biology.

[6]  P L Carson,et al.  Anthropomorphic breast phantoms for assessing ultrasonic imaging system performance and for training ultrasonographers: Part II , 1982, Journal of clinical ultrasound : JCU.

[7]  Maria A. Stuchly,et al.  Measurement of Radio Frequency Permittivity of Biological Tissues with an Open-Ended Coaxial Line: Part I , 1982 .

[8]  Roberto Olmi,et al.  The Polyacrylamide as a Phantom Material for Electromagnetic Hyperthermia Studies , 1984, IEEE Transactions on Biomedical Engineering.

[9]  A. Guy,et al.  Formulas for preparing phantom muscle tissue at various radiofrequencies. , 1984, Bioelectromagnetics.

[10]  J J Lagendijk,et al.  Hyperthermia dough: a fat and bone equivalent phantom to test microwave/radiofrequency hyperthermia heating systems. , 1985, Physics in medicine and biology.

[11]  M B Flamm Detection of breast cancer. , 1987, JAMA.

[12]  E. Madsen,et al.  Anthropomorphic phantoms for assessing systems used in ultrasound imaging of the compressed breast. , 1988, Ultrasound in medicine & biology.

[13]  R. Olmi,et al.  Use of polyacrylamide as a tissue-equivalent material in the microwave range , 1988, IEEE Transactions on Biomedical Engineering.

[14]  M Nadi,et al.  Dielectric properties of gelatine phantoms used for simulations of biological tissues between 10 and 50 MHz. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[15]  P. Strax Detection of breast cancer , 1990, Cancer.

[16]  M. J. Richardson,et al.  New materials for dielectric simulation of tissues. , 1991, Physics in medicine and biology.

[17]  Z Petrovich,et al.  Utilization of a multilayer polyacrylamide phantom for evaluation of hyperthermia applicators. , 1992, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[18]  S. S. Stuchly,et al.  A new aperture admittance model for open-ended waveguides , 1992 .

[19]  S. S. Stuchly,et al.  Dielectric measurements using a rational function model , 1994 .

[20]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[21]  Y. Nikawa,et al.  Soft and dry phantom modeling material using silicone rubber with carbon fiber , 1996 .

[22]  A. Taflove,et al.  Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors , 1998, IEEE Transactions on Biomedical Engineering.

[23]  Paul M. Meaney,et al.  A conductive plastic for simulating biological tissue at microwave frequencies , 2000 .

[24]  S.C. Hagness,et al.  A confocal microwave imaging algorithm for breast cancer detection , 2001, IEEE Microwave and Wireless Components Letters.

[25]  Koichi Ito,et al.  Development and characteristics of a biological tissue‐equivalent phantom for microwaves , 2001 .

[26]  J. Gore,et al.  Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. , 2001, Physics in medicine and biology.

[27]  X. Li,et al.  Confocal microwave imaging for breast cancer detection: localization of tumors in three dimensions , 2002, IEEE Transactions on Biomedical Engineering.

[28]  M. Clemens,et al.  Reduced vector potential formulations for FI2TD schemes , 2002 .

[29]  G. Fixter,et al.  Design of solid broadband human tissue simulant materials , 2002 .

[30]  Claire McCann,et al.  Feasibility of salvage interstitial microwave thermal therapy for prostate carcinoma following failed brachytherapy: studies in a tissue equivalent phantom. , 2003, Physics in medicine and biology.

[31]  Ian J Craddock,et al.  Numerical investigation of breast tumour detection using multi-static radar , 2003 .

[32]  Xu Li,et al.  Microwave imaging via space-time beamforming for early detection of breast cancer , 2003 .

[33]  Takayuki Obata,et al.  Development of a dielectric equivalent gel for better impedance matching for human skin , 2003, Bioelectromagnetics.

[34]  A. Rubio Bretones,et al.  A ROTATING ARRAY OF ANTENNAS FOR CONFOCAL MICROWAVE BREAST IMAGING , 2003 .

[35]  S. Davidson,et al.  Measurement of the thermal conductivity of polyacrylamide tissue-equivalent material , 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[36]  D. W. van der Weide,et al.  Microwave imaging via space-time beamforming: experimental investigation of tumor detection in multilayer breast phantoms , 2004, IEEE Transactions on Microwave Theory and Techniques.

[37]  T. Peters,et al.  Poly(vinyl alcohol) cryogel phantoms for use in ultrasound and MR imaging , 2004, Physics in medicine and biology.

[38]  Quing Zhu,et al.  Modeling of noninvasive microwave characterization of breast tumors , 2004, IEEE Transactions on Biomedical Engineering.

[39]  Magda El-Shenawee,et al.  Resonant spectra of Malignant breast cancer tumors using the three-dimensional Electromagnetic Fast multipole model , 2004, IEEE Transactions on Biomedical Engineering.

[40]  Barry D. Van Veen,et al.  Ultrawideband microwave breast cancer detection: a detection-theoretic approach using the generalized likelihood ratio test , 2005, IEEE Transactions on Biomedical Engineering.

[41]  M. Okoniewski,et al.  Precision open-ended coaxial probes for in vivo and ex vivo dielectric spectroscopy of biological tissues at microwave frequencies , 2005, IEEE Transactions on Microwave Theory and Techniques.