Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

[1]  H. Nagase,et al.  Opioids in preclinical and clinical trials. , 2011, Topics in current chemistry.

[2]  H. Nagase,et al.  Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration. , 2010, Bioorganic & medicinal chemistry letters.

[3]  Y. Six,et al.  Synthetic transformations mediated by the combination of titanium(IV) alkoxides and grignard reagents: selectivity issues and recent applications. Part 1: reactions of carbonyl derivatives and nitriles , 2010 .

[4]  N. Yamaotsu,et al.  Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. , 2010, Bioorganic & medicinal chemistry letters.

[5]  A. Zhang,et al.  Synthesis and opioid receptor activity of indolopropellanes. , 2009, Bioorganic & medicinal chemistry letters.

[6]  S. Hirono,et al.  Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. , 2009, Bioorganic & medicinal chemistry letters.

[7]  H. Nagase,et al.  Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction. , 2009, Bioorganic & medicinal chemistry letters.

[8]  H. Mochizuki,et al.  Nalfurafine hydrochloride: a new drug for the treatment of uremic pruritus in hemodialysis patients. , 2009, Drugs of today.

[9]  M. Narita,et al.  Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology. , 2008, Bioorganic & medicinal chemistry letters.

[10]  H. Nagase,et al.  Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. , 2008, Bioorganic & medicinal chemistry.

[11]  S. Hirono,et al.  Synthesis of a stable iminium salt and propellane derivatives. , 2008, The Journal of organic chemistry.

[12]  H. Nagase,et al.  Rational Drug Design of Selective ℇ Opioid Receptor Agonist TAN-821 and Antagonist TAN-1014 , 2006 .

[13]  James B. Thomas,et al.  N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)-7α-amidomorphans Are Potent, Selective κ Opioid Receptor Antagonists , 2006 .

[14]  J. Deschamps,et al.  N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists. , 2005, Journal of medicinal chemistry.

[15]  Ulrike Holzgrabe,et al.  Comparison of Pharmacological Activities of Three Distinct κ Ligands (Salvinorin A, TRK-820 and 3FLB) on κ Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo , 2005, Journal of Pharmacology and Experimental Therapeutics.

[16]  O. Kulinkovich Synthetic Applications of Intermolecular Cyclopropanation of Carboxylic Esters with Dialkoxytitanacyclopropane Reagents , 2004 .

[17]  M. Narita,et al.  Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats. , 2004, Life sciences.

[18]  M. Narita,et al.  Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor. , 2004, Bioorganic & medicinal chemistry.

[19]  Ronald F. Mucha,et al.  Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning , 2004, Psychopharmacology.

[20]  F I Carroll,et al.  Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. , 2001, Journal of medicinal chemistry.

[21]  J. Kamei,et al.  The pharmacological profile of δ opioid receptor ligands, (+) and (−) TAN-67 on pain modulation , 2001 .

[22]  M. Narita,et al.  The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice. , 2001, Life sciences.

[23]  M. Narita,et al.  The novel kappa-opioid receptor agonist TRK-820 has no affect on the development of antinociceptive tolerance to morphine in mice. , 2000, European journal of pharmacology.

[24]  J. Kamei,et al.  Characterization of the antinociceptive effects of TRK-820 in the rat. , 2000, European journal of pharmacology.

[25]  M. Narita,et al.  Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist , 1999 .

[26]  H. Nagase,et al.  Pharmacological properties of TRK-820 on cloned μ-, δ- and κ-opioid receptors and nociceptin receptor , 1999 .

[27]  H. Nagase,et al.  Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67). , 1998, Chemical & pharmaceutical bulletin.

[28]  H. Nagase,et al.  Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan. , 1998, Chemical & pharmaceutical bulletin.

[29]  P B Bradley,et al.  International Union of Pharmacology. XII. Classification of opioid receptors. , 1996, Pharmacological reviews.

[30]  M. Millan κ-Opioid receptors and analgesia , 1990 .

[31]  G. Pasternak,et al.  Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. , 1989, The Journal of pharmacology and experimental therapeutics.

[32]  R. Zukin,et al.  Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[33]  D. L. Larson,et al.  Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity. , 1988, Journal of medicinal chemistry.

[34]  J. Mccall,et al.  [3H]U-69593 a highly selective ligand for the opioid κ receptor , 1985 .

[35]  R. Lahti,et al.  Properties of a selective kappa agonist, U-50,488H. , 1982, Life sciences.

[36]  P. von Voigtlander,et al.  Benzeneacetamide amines: structurally novel non-m mu opioids. , 1982, Journal of medicinal chemistry.