Immunological discrimination between self and non-self by precursor depletion and memory accumulation.

[1]  R. Owen.  IMMUNOGENETIC CONSEQUENCES OF VASCULAR ANASTOMOSES BETWEEN BOVINE TWINS. , 1945, Science.

[2]  F. Burnet,et al.  The production of antibodies , 1949 .

[3]  P. Medawar,et al.  ‘Actively Acquired Tolerance’ of Foreign Cells , 1953, Nature.

[4]  J. Humphrey.  IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. I. THE DURATION OF UNRESPONSIVENESS FOLLOWING A SINGLE INJECTION AT BIRTH. , 1964, Immunology.

[5]  Melvin Cohn,et al.  A Theory of Self-Nonself Discrimination , 1970, Science.

[6]  L. Old,et al.  Rejection of Skin Allografts by Radiation Chimaeras: Selective Gene Action in the Specification of Cell Surface Structure , 1970, Nature.

[7]  W. Weigle.  Recent observations and concepts in immunological unresponsiveness and autoimmunity. , 1971, Clinical and experimental immunology.

[8]  L. Old,et al.  Tolerance of Sk-incompatibte Skin Grafts , 1973, Nature.

[9]  R. Zinkernagel,et al.  H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T- cell specificities are associated with structures coded for in H-2K or H-2D; , 1975, The Journal of experimental medicine.

[10]  E. Metcalf,et al.  In vitro tolerance induction of neonatal murine B cells. , 1976, The Journal of experimental medicine.

[11]  E. Metcalf,et al.  In vitro tolerance induction of bone marrow cells: a marker for B cell maturation. , 1977, Journal of immunology.

[12]  R. Zinkernagel,et al.  On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? , 1978, The Journal of experimental medicine.

[13]  R. Gorczynski,et al.  Suppression of cytotoxic response to histoincompatible cells. II. Analysis of the role of two independent T suppressor pools in maintenance of neonatally induced allograft tolerance in mice. , 1979, Journal of immunology.

[14]  R. Gorczynski,et al.  Suppression of cytotoxic response to histoincompatible cells. I. Evidence for two types of T lymphocyte-derived suppressors acting at different stages in the induction of a cytotoxic response. , 1979, Journal of immunology.

[15]  H. Claman.  T-cell tolerance—One signal? , 1979 .

[16]  I. Hilgert.  The Involvement of Activated Specific Suppressor T Cells in Maintenance of Transplantation Tolerance , 1979, Immunological reviews.

[17]  G. Nossal,et al.  In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T- dependent responsive B cells by antigen , 1979, The Journal of experimental medicine.

[18]  L. Hood,et al.  An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH , 1980, Cell.

[19]  H. Claman,et al.  T cell signals: tolerance to DNFB is converted to sensitization by a separate nonspecific second signal. , 1980, Journal of immunology.

[20]  H. Macdonald,et al.  Quantitation and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors , 1981, The Journal of experimental medicine.

[21]  W. Droege.  A random repertoire of V genes for T-cell receptors? Theoretical implications of recent experimental observations on T-cell specificity and self-restriction. , 1981, Cellular immunology.

[22]  W. Dröge.  Theoretical considerations and probability models for the somatic development of the T-cell repertoire. , 1981, Cellular immunology.

[23]  F. Bach,et al.  Antigen-driven helper cell-independent cloned cytolytic T lymphocytes , 1981, Nature.

[24]  Z. Grossman.  Recognition of self, balance of growth and competition: Horizontal networks regulate immune responsiveness , 1982, European journal of immunology.

[25]  Stephen J. Merrill,et al.  Foundations of the use of an enzyme-kinetic analogy in cell-mediated cytotoxicity☆ , 1982 .

[26]  F. Bach,et al.  The cellular mechanism of maintenance of neonatally induced tolerance to H-2 class I antigens. , 1983, Journal of immunology.

[27]  C. Orosz,et al.  Helper cell-independent cytolytic T lymphocytes specific for a minor histocompatibility antigen. , 1983, Journal of immunology.

[28]  J. Louis,et al.  Clonal analysis of T cell unresponsiveness to alloantigens induced by neonatal injection of F1 spleen cells into parental mice. , 1983, Journal of immunology.

[29]  G. Nossal.  Cellular mechanisms of immunologic tolerance. , 1983, Annual review of immunology.

[30]  S. Ishizaka,et al.  Analysis by limiting dilution of interleukin 2‐producing T cells in murine ontogeny , 1983, European journal of immunology.

[31]  A. Coutinho,et al.  Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs. , 1983, Journal of immunology.

[32]  S. Levin.  Lectu re Notes in Biomathematics , 1983 .

[33]  S. Ishizaka,et al.  Early loss of precursors of CTL and IL 2-producing cells in the development of neonatal tolerance to alloantigens. , 1984, Journal of immunology.

[34]  Mark M. Davis,et al.  Somatic recombination in a murine T-cell receptor gene , 1984, Nature.

[35]  N. K. Jerne,et al.  Idiotypic Networks and Other Preconceived Ideas , 1984, Immunological reviews.

[36]  P. Medawar,et al.  Is immunological tolerance (non-responsiveness) a consequence of interleukin 2 deficit during the recognition of antigen? , 1984, Immunology today.

[37]  E. Unanue.  Antigen-presenting function of the macrophage. , 1984, Annual review of immunology.

[38]  J. Ihle,et al.  Comparison of allogeneic and self-restricted stimulation of lymphokine production by dual-reactive cloned T cells. , 1984, Journal of immunology.

[39]  K. Shortman,et al.  T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants , 1984, Immunological reviews.

[40]  A. Mustafa,et al.  Reversal by Interleukin‐2 of the T Cell Unresponsiveness of Lepromatous Leprosy to Mycobacterium Leprae , 1984, Immunological reviews.

[41]  D. Cantrell,et al.  The interleukin-2 T-cell system: a new cell growth model. , 1984, Science.

[42]  B. Argyris.  The interaction between macrophages and suppressor cells in immunological maturation in mice. , 1984, Immunology today.

[43]  Z. Grossman,et al.  Recognition of Self and Regulation of Specificity at the Level of Cell Populations , 1984, Immunological reviews.

[44]  K. Smith.  Inside the thymus. , 1984, Immunology today.

[45]  A. Basten,et al.  Induction of memory and effector suppressor T cells by perinatal exposure to antigen , 1984, European journal of immunology.

[46]  C. Milstein,et al.  Somatic mutation and the maturation of immune response to 2-phenyl oxazolone , 1984, Nature.

[47]  J. Levy,et al.  Natural suppressor cell inhibiting T killer responses against retroviruses: a model for self tolerance. , 1985, Journal of immunology.

[48]  A. Weiss,et al.  T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. , 1985, Journal of immunology.

[49]  G. M. Griffiths,et al.  Molecular events during maturation of the immune response to oxazolone , 1985, Nature.

[50]  S. Rosenberg,et al.  In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. , 1985, Journal of immunology.

[51]  B. Rouse,et al.  Frequency of herpes simplex virus-specific helper T lymphocyte precursors in the lymph node cells of infected mice. , 1985, Journal of immunology.

[52]  P Hogeweg,et al.  Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model. , 1985, Journal of immunology.

[53]  V. Paetkau,et al.  Interaction of interleukin 2 with cells: quantitative analysis of effects. , 1985, Journal of immunology.

[54]  L. Hood,et al.  The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments , 1985, Nature.

[55]  S. Rosenberg,et al.  In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2. , 1985, Journal of immunology.

[56]  P Hogeweg,et al.  Tumor escape from immune elimination: simplified precursor bound cytotoxicity models. , 1985, Journal of theoretical biology.

[57]  P Hogeweg,et al.  Interactions between macrophages and T-lymphocytes: tumor sneaking through intrinsic to helper T cell dynamics. , 1986, Journal of theoretical biology.

[58]  B. Kyewski,et al.  Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation , 1986, The Journal of experimental medicine.

[59]  B. Stockinger,et al.  Adsorption on B cell hybridomas removes suppressor cells from spleen cells of neonatally tolerized mice , 1986, European journal of immunology.

[60]  R. Schwartz,et al.  High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules. , 1986, Journal of immunology.

[61]  R. Miller,et al.  Stages of T cell activation: continued antigen dependence of IL 2-producing cells after IL 2 receptor expression. , 1986, Journal of immunology.

[62]  N. Shastri,et al.  Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation , 1986, Nature.

[63]  P Hogeweg,et al.  Concomitant immunization by the fully antigenic counterparts prevents modulated tumor cells from escaping cellular immune elimination. , 1986, Journal of immunology.

[64]  H. Kolb,et al.  Recombinant interleukin 2 enhances spontaneous insulin‐dependent diabetes in BB rats , 1986, European journal of immunology.

[65]  K. Matsushima,et al.  There is more than one interleukin 1. , 1986, Immunology today.