DB110726 2853..2860

RESEARCH DESIGN AND METHODS—Whole pancreata from untreated (n = 3), MnCl2 and glucose-injected mice (n = 6), and mice injected with either streptozotocin (STZ; n = 4) or citrate buffer (n = 4) were imaged ex vivo for unambiguous evaluation of islets. Exteriorized pancreata of MnCl2 and glucose-injected mice (n = 6) were imaged in vivo to directly visualize the gland and minimize movements. In all cases, MR images were acquired in a 14.1 Tesla scanner and correlated with the corresponding (immuno)histological sections.

[1]  Greg M. Thurber,et al.  Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog , 2011, Proceedings of the National Academy of Sciences.

[2]  Rolf Gruetter,et al.  Diffusion tensor echo planar imaging using surface coil transceiver with a semiadiabatic RF pulse sequence at 14.1T , 2011, Magnetic resonance in medicine.

[3]  Sabina Muend,et al.  Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cells , 2011, BioMetals.

[4]  J. Gaglia,et al.  Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. , 2011, The Journal of clinical investigation.

[5]  P. Meda,et al.  Assessment of Human Islet Labeling with Clinical Grade Iron Nanoparticles Prior to Transplantation for Graft Monitoring by MRI , 2010, Cell transplantation.

[6]  W. Oyen,et al.  Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques , 2010, The Journal of Nuclear Medicine.

[7]  V. Tolmachev,et al.  Radionuclide molecular imaging using Affibody molecules. , 2010, Current pharmaceutical biotechnology.

[8]  J. Gaglia,et al.  Near-infrared fluorescent probe for imaging of pancreatic beta cells. , 2010, Bioconjugate chemistry.

[9]  K. Thulborn,et al.  Vital signs and cognitive function are not affected by 23‐sodium and 17‐oxygen magnetic resonance imaging of the human brain at 9.4 T , 2010, Journal of magnetic resonance imaging : JMRI.

[10]  L. Leoni,et al.  MR imaging of pancreatic islets: tracking isolation, transplantation and function. , 2010, Current pharmaceutical design.

[11]  L. Eliasson,et al.  Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCα and PKCδ , 2010, Diabetologia.

[12]  T. Yen,et al.  Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles. , 2009, Transplantation proceedings.

[13]  F. Epstein,et al.  Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. , 2009, American journal of physiology. Endocrinology and metabolism.

[14]  J. Virostko,et al.  Molecular imaging of the pancreas in small animal models. , 2009, Gastroenterology.

[15]  S. Schneider.  Efforts to develop methods for in vivo evaluation of the native β‐cell mass , 2008, Diabetes, obesity & metabolism.

[16]  Ting Song,et al.  A review of imaging techniques for systems biology , 2008, BMC Systems Biology.

[17]  M. Köhler,et al.  Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye , 2008, Nature Protocols.

[18]  R. Weissleder,et al.  Imaging in the era of molecular oncology , 2008, Nature.

[19]  F. Ris,et al.  Clinical Magnetic Resonance Imaging of Pancreatic Islet Grafts After Iron Nanoparticle Labeling , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[20]  D. Koh,et al.  Size distribution of mouse Langerhans islets. , 2007, Biophysical journal.

[21]  F. Ris,et al.  [Islet autotransplantation to prevent diabetes after pancreatectomy for benign disease of the pancreas]. , 2007, Revue medicale suisse.

[22]  Brian Rutt,et al.  Imaging Islets Labeled With Magnetic Nanoparticles at 1.5 Tesla , 2006, Diabetes.

[23]  M. Freeby,et al.  Current progress in non-invasive imaging of beta cell mass of the endocrine pancreas. , 2006, Current medicinal chemistry.

[24]  E. Jansen,et al.  Current status of imaging pancreatic islets , 2006, Current diabetes reports.

[25]  D. Hill,et al.  Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. , 2006, Endocrinology.

[26]  E. Jansen,et al.  A Novel Method of Monitoring Response to Islet Transplantation: Bioluminescent Imaging of an NF-kB Transgenic Mouse Model , 2006, Transplantation.

[27]  G. Camussi,et al.  Platelet-Activating Factor Synthesis and Response on Pancreatic Islet Endothelial Cells: Relevance for Islet Transplantation , 2006, Transplantation.

[28]  Ichio Aoki,et al.  Manganese‐enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations , 2004, NMR in biomedicine.

[29]  Afonso C. Silva,et al.  Manganese‐enhanced magnetic resonance imaging (MEMRI) , 2004, NMR in biomedicine.

[30]  R. Weissleder,et al.  Imaging inflammation of the pancreatic islets in type 1 diabetes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[31]  S. Wild,et al.  Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. , 2004, Diabetes care.

[32]  J. Kowalewski,et al.  Field-dependent proton relaxation in aqueous solutions of some manganese(II) complexes: a new interpretation , 2003, JBIC Journal of Biological Inorganic Chemistry.

[33]  J. Glusker,et al.  The arrangement of first- and second-shell water molecules in trivalent aluminum complexes: results from density functional theory and structural crystallography. , 2003, Inorganic chemistry.

[34]  M. Janjua,et al.  The optimum dose of nicotinamide for protection of pancreatic beta-cells against the cytotoxic effect of streptozotocin in albino rat. , 2001, Journal of Ayub Medical College, Abbottabad : JAMC.

[35]  G. Nepom,et al.  Low-Dose Streptozotocin Induces Sustained Hyperglycemia in Macaca nemestrina , 2001, Autoimmunity.

[36]  F. Karlsson,et al.  Expression of Pancreatic Islet MHC Class I, Insulin, and ICA 512 Tyrosine Phosphatase in Low-dose Streptozotocin-induced Diabetes in Mice , 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[37]  A A Elayat,et al.  An immunocytochemical and morphometric study of the rat pancreatic islets. , 1995, Journal of anatomy.

[38]  C. Newgard,et al.  STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells , 1994, Diabetes.

[39]  S. Bonner-Weir,et al.  Correlations of In Vivo β-Cell Function Tests With β-Cell Mass and Pancreatic Insulin Content in Streptozocin-Administered Baboons , 1991, Diabetes.

[40]  G. Grodsky,et al.  Progressive Damage of Cultured Pancreatic Islets After Single Early Exposure to Streptozocin , 1986, Diabetes.

[41]  L. Skovgaard,et al.  Pancreatic islet volume distribution: direct measurement in preparations stained by perfusion in situ. , 1984, Acta endocrinologica.

[42]  Å. Lernmark,et al.  A Major Loss in Islet Mass and B-cell Function Precedes Hyperglycemia in Mice Given Multiple Low Doses of Streptozotocin , 1981, Diabetes.

[43]  K. Murase,et al.  Measurement of manganese content in various organs in rats with or without glucose stimulation , 2011, Radiological physics and technology.

[44]  M. Gotthardt,et al.  Approaches for imaging islets: recent advances and future prospects. , 2010, Advances in experimental medicine and biology.

[45]  T. Desai,et al.  Functional MR microimaging of pancreatic beta-cell activation. , 2006, Cell transplantation.

[46]  Anna Moore,et al.  In vivo imaging of islet transplantation , 2006, Nature Medicine.

[47]  T. Blackwell,et al.  BIOLUMINESCENT IMAGING OF AN NF-kB TRANSGENIC MOUSE MODEL FOR MONITORING IMMUNE RESPONSE TO A BIOARTIFICIAL PANCREAS REAL TIME AND IN VIVO : VALIDATION OF THE METHOD , 2005 .

[48]  S. Schulte im Walde,et al.  Differential target molecules for toxicity induced by streptozotocin and alloxan in pancreatic islets of mice in vitro. , 2004, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[49]  S. Brolin,et al.  Histochemical observations on the pancreatic islets in normal and obese-hyperglycemic mice , 2004, Zeitschrift für Zellforschung und Mikroskopische Anatomie.