Protooncogene c-fos as a transcription factor.

Publisher Summary This chapter discusses the recent advances in the understanding of cellular gene regulation by c-fos—the cellular homolog of the transforming gene (v-fos) of the murine sarcoma viruses FBJ and FBR. The v-fos and c-fos genes are both capable of transforming fibroblasts, although the c-fos gene requires structural alterations. One of the ways of elevating c-fos levels is to transfect cells with an activated c-fos gene. The level of modification for c-fos appears to be dependent on the inducing agent used. If c-fos and c-jun are found in a single complex, then transcription factor AP-1 purified by sequence-specific DNA affinity chromatography can be expected to contain c-fos. The c-fos plays a role in the trans-activation of the TRE as antisense RNA to c-fos completely prevents trans-activation via the TRE when cells are stimulated by a number of agents. The role of c-fos in modulating the DNA-binding activity of c-jun is investigated in the chapter using proteins synthesized in rabbit reticulocyte translation systems from purified mRNA.

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