Evaluation of pelvic washing specimens in patients with endometrial cancer: Cytomorphological features, diagnostic agreement, and pathologist experience

Pelvic washings for patients with endometrial cancer is recommended but not used for staging. The International System for Reporting Serous Fluid Cytology (TIS) has standardized diagnostic categories, but the criteria remain incomplete. The 3 primary goals of this study were to 1) investigate features that distinguish atypical/indeterminate from malignant specimens, 2) measure the level of agreement between chart and reviewer diagnoses, and 3) determine whether the number of years in practice had an effect on the diagnoses rendered.

[1]  F. Schmitt,et al.  The international system for reporting serous fluid cytopathology-diagnostic categories and clinical management. , 2020, Journal of the American Society of Cytopathology.

[2]  R. Pastorello,et al.  Application of the International System for Reporting Serous Fluid Cytopathology (ISRSFC) on Reporting Pericardial Effusion Cytology , 2020, Acta Cytologica.

[3]  J. Lang,et al.  The prognostic role of peritoneal cytology in stage IA endometrial endometrioid carcinomas. , 2019, Current problems in cancer.

[4]  J. Reynolds,et al.  Primary tumor types and origins in positive abdominopelvic washing cytology, a single institution experience. , 2019, Journal of the American Society of Cytopathology.

[5]  G. Piaggio,et al.  The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker. , 2019, Surgical oncology.

[6]  P. Mozetic,et al.  Seriate cytology vs molecular analysis of peritoneal washing to improve gastric cancer cells detection , 2019, Diagnostic cytopathology.

[7]  D. Bell,et al.  Molecular Genetics of Endometrial Carcinoma. , 2019, Annual review of pathology.

[8]  Matthew P. Goetz,et al.  NCCN CLINICAL PRACTICE GUIDELINES IN ONCOLOGY , 2019 .

[9]  K. Sundling,et al.  Ancillary studies in pleural, pericardial, and peritoneal effusion cytology , 2018, Cancer cytopathology.

[10]  S. Bean,et al.  Evolving Roles of Histologic Evaluation and Molecular/Genomic Profiling in the Management of Endometrial Cancer. , 2018, Journal of the National Comprehensive Cancer Network : JNCCN.

[11]  Kathleen R. Cho,et al.  Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology. , 2018, Journal of the National Comprehensive Cancer Network : JNCCN.

[12]  L. Yoxtheimer,et al.  The role of peritoneal washings in the diagnosis of endometriosis , 2018, Diagnostic cytopathology.

[13]  B. Seagle,et al.  Prognosis and treatment of positive peritoneal cytology in early endometrial cancer: matched cohort analyses from the National Cancer Database , 2017, American journal of obstetrics and gynecology.

[14]  S. Temkin,et al.  Impact of histology and surgical approach on survival among women with early-stage, high-grade uterine cancer: An NRG Oncology/Gynecologic Oncology Group ancillary analysis. , 2016, Gynecologic oncology.

[15]  C. VandenBussche,et al.  Concordance of Expert Consultation Diagnoses in the Review of Pelvic Washing Specimens , 2015, Acta Cytologica.

[16]  S. Pambuccian.  What is atypia? Use, misuse and overuse of the term atypia in diagnostic cytopathology. , 2015, Journal of the American Society of Cytopathology.

[17]  A. Berchuck,et al.  Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients. , 2014, Gynecologic oncology.

[18]  T. Ikeda,et al.  Does Positive Peritoneal Cytology Not Affect the Prognosis for Stage I Uterine Endometrial Cancer?: The Remaining Controversy and Review of the Literature , 2014, International Journal of Gynecologic Cancer.

[19]  R. Barakat,et al.  Positive peritoneal cytology is highly predictive of prognosis and relapse patterns in stage III (FIGO 2009) endometrial cancer. , 2013, Gynecologic oncology.

[20]  Jason D. Wright,et al.  Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer. , 2013, Gynecologic oncology.

[21]  B. Kong,et al.  Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology. , 2012, Gynecologic oncology.

[22]  A. Ayhan,et al.  Comparison of FIGO 1988 and 2009 staging systems for endometrial carcinoma , 2012, Medical Oncology.

[23]  Longwen Chen,et al.  Cytology: Diagnostic Principles and Clinical Correlates , 2010 .

[24]  T. Herzog,et al.  Prognostic significance and treatment implications of positive peritoneal cytology in endometrial adenocarcinoma: Unraveling a mystery. , 2009, Gynecologic oncology.

[25]  R. Mclellan,et al.  Peritoneal cytology in endometrial cancer: a review. , 1989, Obstetrical & gynecological survey.

[26]  R. Zuna,et al.  Cytohistologic correlation of peritoneal washing cytology in gynecologic disease. , 1989, Acta cytologica.

[27]  E. Ravinsky.  Cytology of peritoneal washings in gynecologic patients. Diagnostic criteria and pitfalls. , 1986, Acta cytologica.