Biology of common β receptor–signaling cytokines: IL-3, IL-5, and GM-CSF

[1]  J. D. English,et al.  Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma , 2004, Journal of Molecular Medicine.

[2]  S. Robertson,et al.  Interleukin-5 Transgene Expression and Eosinophilia Are Associated with Retarded Mammary Gland Development in Mice1 , 2003, Biology of reproduction.

[3]  H. Strobl.  Molecular Mechanisms of Dendritic Cell Sublineage Development from Human Hematopoietic Progenitor/Stem Cells , 2003, International Archives of Allergy and Immunology.

[4]  K. Akashi,et al.  Enforced Granulocyte/Macrophage Colony-stimulating Factor Signals Do Not Support Lymphopoiesis, but Instruct Lymphoid to Myelomonocytic Lineage Conversion , 2003, The Journal of experimental medicine.

[5]  J. Kurtzberg,et al.  Absolute Values of Dendritic Cell Subsets in Bone Marrow, Cord Blood, and Peripheral Blood Enumerated by a Novel Method , 2003, Stem cells.

[6]  A. Kay,et al.  Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. , 2003, American journal of respiratory and critical care medicine.

[7]  M. Kavuru,et al.  Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis. , 2002, Clinical immunology.

[8]  A. Karsan,et al.  Interleukin‐3, but not granulocyte–macrophage colony‐stimulating factor and interleukin‐5, inhibits apoptosis of human basophils through phosphatidylinositol 3‐kinase: requirement of NF‐κB‐dependent and ‐independent pathways , 2002, Immunology.

[9]  A. Whetton,et al.  Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors. , 2002, Blood.

[10]  E. Coccia,et al.  Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis. , 2002, Blood.

[11]  M. Kavuru,et al.  Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis. , 2002, American journal of respiratory cell and molecular biology.

[12]  M. Manns,et al.  Cultured human intestinal mast cells express functional IL‐3 receptors and respond to IL‐3 by enhancing growth and IgE receptor‐dependent mediator release , 2002, European journal of immunology.

[13]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[14]  S. Hofer,et al.  A Novel Role for IL-3: Human Monocytes Cultured in the Presence of IL-3 and IL-4 Differentiate into Dendritic Cells That Produce Less IL-12 and Shift Th Cell Responses Toward a Th2 Cytokine Pattern1 , 2002, The Journal of Immunology.

[15]  Lewis C Cantley,et al.  The phosphoinositide 3-kinase pathway. , 2002, Science.

[16]  J. Emile,et al.  Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia. , 2002, Blood.

[17]  S. Bhattacharya,et al.  Signaling through the JAK/STAT pathway, recent advances and future challenges. , 2002, Gene.

[18]  D. Ribatti,et al.  In vivo activation of JAK2/STAT‐3 pathway during angiogenesis induced by GM‐CSF , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  M. Martinez-Moczygemba,et al.  Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. , 2001, The Journal of clinical investigation.

[20]  T. Zuberbier,et al.  Effect of granulocyte macrophage colony‐stimulating factor in a patient with benign systemic mastocytosis , 2001, The British journal of dermatology.

[21]  John Armstrong,et al.  Cytokine-Specific Transcriptional Regulation Through an IL-5Rα Interacting Protein , 2001, Science.

[22]  D. Ollis,et al.  Expression, crystallization and derivatization of the complete extracellular domain of the beta(c) subunit of the human IL-5, IL-3 and GM-CSF receptors. , 2001, European journal of biochemistry.

[23]  T. Zuberbier,et al.  GM-CSF downmodulates c-kit, FcεRIα and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells , 2001, Archives of Dermatological Research.

[24]  Angel F. Lopez,et al.  Structural and Functional Hot Spots in Cytokine Receptors , 2001, International journal of hematology.

[25]  P. Coffer,et al.  Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. , 2001, Cytokine & growth factor reviews.

[26]  O. Segatto,et al.  Negative regulation of receptor tyrosine kinase signals , 2001, FEBS letters.

[27]  Ian Walker,et al.  Structure of the Complete Extracellular Domain of the Common β Subunit of the Human GM-CSF, IL-3, and IL-5 Receptors Reveals a Novel Dimer Configuration , 2001, Cell.

[28]  A. Aventín,et al.  Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies. , 2001, Haematologica.

[29]  K. Chung,et al.  Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response , 2000, The Lancet.

[30]  I. G. Young,et al.  Uterine eosinophils and reproductive performance in interleukin 5-deficient mice. , 2000, Journal of reproduction and fertility.

[31]  James J. Lee,et al.  Role of IL-5 in Innate and Adaptive Immunity to Larval Strongyloides stercoralis in Mice1 , 2000, The Journal of Immunology.

[32]  S. Collins,et al.  Interleukin‐5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections , 2000, Parasite immunology.

[33]  M. Dottore,et al.  Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. , 2000, Molecular cell.

[34]  G. Mills,et al.  Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway , 1999, Oncogene.

[35]  M. Scheid,et al.  Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase* , 1999, The Journal of Biological Chemistry.

[36]  C. Bagley,et al.  The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications. , 1999, The international journal of biochemistry & cell biology.

[37]  C. Begley,et al.  The beta common chain (beta c) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and interleukin-5 receptors. , 1999, The international journal of biochemistry & cell biology.

[38]  D. H. Zhang,et al.  Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. , 1999, Immunity.

[39]  M. Dottore,et al.  Identification of a 14-3-3 Binding Sequence in the Common β Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF , 1999 .

[40]  K. Leong,et al.  Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma. , 1999, The Journal of allergy and clinical immunology.

[41]  D. Hilton,et al.  Negative regulation of the JAK/STAT pathway , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[42]  J. Armitage.  Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor , 1998 .

[43]  Y. Ogata,et al.  Eosinophilia associated with adult t‐cell leukemia: Role of interleukin 5 and granulocyte‐macrophage colony‐stimulating factor , 1998, American journal of hematology.

[44]  P. Coffer,et al.  Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. , 1998, Cellular signalling.

[45]  D. Chang,et al.  Inhibition of Stat1-mediated gene activation by PIAS1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Angel F. Lopez,et al.  Mechanism of Activation of the GM‐CSF, IL‐3, and IL‐5 Family of Receptors , 1998, Stem cells.

[47]  T. Adachi,et al.  The mechanism of IL-5 signal transduction. , 1998, The American journal of physiology.

[48]  P. O'Byrne,et al.  Enhanced expression of GM-CSF in differentiating eosinophils of atopic and atopic asthmatic subjects. , 1998, American journal of respiratory cell and molecular biology.

[49]  Angel F. Lopez,et al.  IL-3, IL-5, granulocyte-macrophage colony- stimulating factor receptor α-subunit, and common β-subunit expression by peripheral leukocytes and blood dendritic cells , 1998 .

[50]  G. Dranoff,et al.  Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites , 1998, Nature.

[51]  Q. Sun,et al.  Identification of a Cys Motif in the Common β Chain of the Interleukin 3, Granulocyte-Macrophage Colony-stimulating Factor, and Interleukin 5 Receptors Essential for Disulfide-linked Receptor Heterodimerization and Activation of All Three Receptors* , 1998, The Journal of Biological Chemistry.

[52]  K. Yamada,et al.  Expression of cytokine receptors on follicular dendritic cells. , 1997, Blood.

[53]  P. O'Byrne,et al.  Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. , 1997, The Journal of clinical investigation.

[54]  A. Ashworth,et al.  A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells , 1997, Current Biology.

[55]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[56]  T. Adachi,et al.  Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival , 1997, The Journal of experimental medicine.

[57]  S. Yokoyama,et al.  Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells , 1997, Oncogene.

[58]  E. Nishida,et al.  Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3. , 1997, Blood.

[59]  L. Koenderman,et al.  Multiple tyrosine residues in the intracellular domain of the common β subunit of the interleukin 5 receptor are involved in activation of STAT5 , 1997, FEBS letters.

[60]  S. Akira,et al.  Structure and function of a new STAT-induced STAT inhibitor , 1997, Nature.

[61]  Takaho A. Endo,et al.  A new protein containing an SH2 domain that inhibits JAK kinases , 1997, Nature.

[62]  Warren S. Alexander,et al.  A family of cytokine-inducible inhibitors of signalling , 1997, Nature.

[63]  E. Gelfand,et al.  Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma , 1997, The Journal of experimental medicine.

[64]  M. Sporn.  Growth factors and cytokines in health and disease , 1997 .

[65]  M. Welham,et al.  SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates. , 1997, The Journal of biological chemistry.

[66]  K. Arai,et al.  Activation of c-Jun N-terminal kinase by human granulocyte macrophage-colony stimulating factor in BA/F3 cells. , 1997, Biochemical and biophysical research communications.

[67]  J. Lammers,et al.  Activation of 12-O-Tetradecanoylphorbol-13-acetate Response Element- and Dyad Symmetry Element-dependent Transcription by Interleukin-5 Is Mediated by Jun N-terminal Kinase/Stress-activated Protein Kinase Kinases* , 1997, The Journal of Biological Chemistry.

[68]  K. Arai,et al.  JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells (*) , 1996, The Journal of Biological Chemistry.

[69]  J. Miyazaki,et al.  Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. , 1996, Immunity.

[70]  M. Collins,et al.  The role of MAP kinase kinase in interleukin-3 stimulation of proliferation. , 1996, Blood.

[71]  K. Arai,et al.  The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit , 1996, The Journal of experimental medicine.

[72]  G. Mills,et al.  Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils , 1996, The Journal of experimental medicine.

[73]  K. Arai,et al.  Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling (*) , 1996, The Journal of Biological Chemistry.

[74]  D. Huston,et al.  Creation of a biologically active interleukin-5 monomer , 1996, Nature.

[75]  D. Huston,et al.  Delineation of IL-5 domains predicted to engage the IL-5 receptor complex. , 1996, Journal of immunology.

[76]  Robert R. Rich,et al.  Clinical Immunology Principles and Practice , 1996 .

[77]  P. Foster,et al.  Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model , 1996, The Journal of experimental medicine.

[78]  P. Hodgkin,et al.  IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. , 1996, Immunity.

[79]  I. Mellman.  Endocytosis and molecular sorting. , 1996, Annual review of cell and developmental biology.

[80]  C. Begley,et al.  Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[81]  S. Anderson,et al.  Activation of src-related tyrosine kinases by IL-3. , 1995, Journal of immunology.

[82]  R. D'Andrea,et al.  Cytokine receptor genes: structure, chromosomal location, and involvement in human disease. , 1995, Leukemia & lymphoma.

[83]  A. Sauter,et al.  Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[84]  M. Peitsch,et al.  Identification of Key Charged Residues of Human Interleukin-5 in Receptor Binding and Cellular Activation (*) , 1995, The Journal of Biological Chemistry.

[85]  N. Copeland,et al.  A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.

[86]  K. Arai,et al.  Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. , 1995, Oncogene.

[87]  R. Nishinakamura,et al.  Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal , 1995 .

[88]  K. Arai,et al.  Suppression of apoptotic death in hematopoietic cells by signalling through the IL‐3/GM‐CSF receptors. , 1995, The EMBO journal.

[89]  木下 大成.  Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM-CSF receptors , 1995 .

[90]  T. Watanabe,et al.  IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases , 1994, The Journal of experimental medicine.

[91]  P. Emanuel,et al.  Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor. , 1994, Biochimica et biophysica acta.

[92]  P. Lapchak,et al.  Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors , 1994, Neuroscience.

[93]  A. Dunn,et al.  Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[94]  P. Gebicke-haerter,et al.  Changes of β‐amyloid precursor protein splice patterns in brain cell aggregate cultures , 1994, Journal of neuroscience research.

[95]  M. F. Shannon,et al.  Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function. , 1994, The Journal of biological chemistry.

[96]  A Wlodawer,et al.  Structural comparisons among the short-chain helical cytokines. , 1994, Structure.

[97]  M. Vadas,et al.  A cytokine receptor gene cluster in the X-Y pseudoautosomal region? , 1993, Blood.

[98]  M. Lambert,et al.  A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5 , 1993, Nature.

[99]  J. Merrill,et al.  Lymphokine induction of rat microglia multinucleated giant cell formation , 1993, Glia.

[100]  John Calvin Reed,et al.  Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. , 1993, The Journal of biological chemistry.

[101]  J. Tavernier,et al.  Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[102]  M. F. Shannon,et al.  Residue 21 of human granulocyte‐macrophage colony‐stimulating factor is critical for biological activity and for high but not low affinity binding. , 1992, The EMBO journal.

[103]  S. Durham,et al.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. , 1992, The New England journal of medicine.

[104]  K. Blaser,et al.  Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. , 1991, The Journal of allergy and clinical immunology.

[105]  T. Suda,et al.  Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. , 1991, Blood.

[106]  S. Durham,et al.  Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. , 1991, The Journal of allergy and clinical immunology.

[107]  J. Tavernier,et al.  A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF , 1991, Cell.

[108]  K. Arai,et al.  Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors , 1991, Cell.

[109]  G. Widhopf,et al.  Identification and characterization of a low-affinity granulocyte-macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells. , 1991, Blood.

[110]  A. Wardlaw,et al.  Interleukin-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. , 1991, International archives of allergy and applied immunology.

[111]  K. Arai,et al.  Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[112]  A. Wardlaw,et al.  IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. , 1990, Immunology.

[113]  J. Bazan,et al.  Haemopoietic receptors and helical cytokines. , 1990, Immunology today.

[114]  T. Yokota,et al.  Cytokines: coordinators of immune and inflammatory responses. , 1990, Annual review of biochemistry.

[115]  J. Bodmer,et al.  HLA-DR and -DQ epitopes and monoclonal antibody specificity. , 1989, Immunology today.

[116]  I. G. Young,et al.  Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5. , 1989, Blood.

[117]  A. Gazdar,et al.  Nonhematopoietic tumor cells express functional GM-CSF receptors , 1989 .

[118]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.