Hyper-inflammation of astrocytes in patients of major depressive disorder: Evidence from serum astrocyte-derived extracellular vesicles

[1]  O. Wolkowitz,et al.  Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder , 2021, Molecular Psychiatry.

[2]  M. Hotopf,et al.  Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank. , 2021, The American journal of psychiatry.

[3]  M. Mattson,et al.  Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer’s Disease , 2021, Cells.

[4]  E. Savarino,et al.  Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. , 2021, The lancet. Gastroenterology & hepatology.

[5]  G. Terstappen,et al.  Strategies for delivering therapeutics across the blood–brain barrier , 2021, Nature Reviews Drug Discovery.

[6]  V. Stanton,et al.  Tolerogenic nanoparticles suppress central nervous system inflammation , 2020, Proceedings of the National Academy of Sciences.

[7]  Hsin-Yao Tang,et al.  Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice , 2020, Science Translational Medicine.

[8]  F. Quintana,et al.  Astrocyte Crosstalk in CNS Inflammation , 2020, Neuron.

[9]  E. Beurel,et al.  Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice , 2020, Journal of Neuroinflammation.

[10]  Changyong Wang,et al.  A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment , 2020, Journal of Neuroinflammation.

[11]  C. Nemeroff,et al.  The Bidirectional Relationship of Depression and Inflammation: Double Trouble , 2020, Neuron.

[12]  B. Penninx,et al.  Altered peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis , 2020, Brain, Behavior, and Immunity.

[13]  Y. Karamanos,et al.  Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles , 2020, Cells.

[14]  A. Cressant,et al.  Neuroinflammation and depression: A review , 2020, The European journal of neuroscience.

[15]  O. Howes,et al.  Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls , 2020, Brain, Behavior, and Immunity.

[16]  Bradley S. Davidson,et al.  Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  J. Wither,et al.  Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis. , 2020, Seminars in arthritis and rheumatism.

[18]  C. Nievergelt,et al.  Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity , 2019, Front. Neurosci..

[19]  C. Pariante,et al.  Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue , 2019, Brain, Behavior, and Immunity.

[20]  J. Jia,et al.  Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid , 2019, Alzheimer's & Dementia.

[21]  V. Arolt,et al.  Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium , 2019, Front. Psychiatry.

[22]  B. Khakh,et al.  The Emerging Nature of Astrocyte Diversity. , 2019, Annual review of neuroscience.

[23]  D. Fan,et al.  Increased Interleukin-6 Levels in the Astrocyte-Derived Exosomes of Sporadic Amyotrophic Lateral Sclerosis Patients , 2019, Front. Neurosci..

[24]  M. Walter,et al.  The Role of Depressive Subtypes within the Neuroinflammation Hypothesis of Major Depressive Disorder , 2019, Neuroscience.

[25]  J. Loftis,et al.  Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies , 2019, Pharmacology Biochemistry and Behavior.

[26]  Tessandra H Stewart,et al.  New windows into the brain: Central nervous system-derived extracellular vesicles in blood , 2019, Progress in Neurobiology.

[27]  A. Douaihy,et al.  The role of substance use, smoking, and inflammation in risk for suicidal behavior. , 2019, Journal of affective disorders.

[28]  F. Elahi,et al.  Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia , 2018, Alzheimer's & dementia.

[29]  Huaxi Xu,et al.  Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation , 2018, Neuron.

[30]  W. Drevets,et al.  PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects , 2018, EJNMMI Research.

[31]  D. Goldsmith,et al.  What does plasma CRP tell us about peripheral and central inflammation in depression? , 2018, Molecular Psychiatry.

[32]  J. Meldolesi Exosomes and Ectosomes in Intercellular Communication , 2018, Current Biology.

[33]  G. Jicha,et al.  High complement levels in astrocyte‐derived exosomes of Alzheimer disease , 2018, Annals of neurology.

[34]  Sophie E. Holmes,et al.  Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study , 2018, Biological Psychiatry.

[35]  W. K. Simmons,et al.  Depression and obesity: evidence of shared biological mechanisms , 2018, Molecular Psychiatry.

[36]  Ji-Hong Liu,et al.  An astroglial basis of major depressive disorder? An overview , 2017, Glia.

[37]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[38]  E. Goetzl,et al.  Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes , 2017, Front. Neurosci..

[39]  A. Carvalho,et al.  Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies , 2017, Acta psychiatrica Scandinavica.

[40]  D. Llewellyn,et al.  The effects of acute inflammation on cognitive functioning and emotional processing in humans: A systematic review of experimental studies. , 2017, Journal of psychosomatic research.

[41]  O. Wolkowitz,et al.  Oxidative stress, inflammation and treatment response in major depression , 2017, Psychoneuroendocrinology.

[42]  E. Goetzl,et al.  Multicellular hypothesis for the pathogenesis of Alzheimer's disease , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  M. Fava,et al.  Inflammatory cytokines in major depressive disorder: A case–control study , 2017, The Australian and New Zealand journal of psychiatry.

[44]  Andrew H. Miller,et al.  Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation , 2017, Neuropsychopharmacology.

[45]  D. Goldsmith,et al.  A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression , 2016, Molecular Psychiatry.

[46]  C. Escartin,et al.  The complex STATes of astrocyte reactivity: How are they controlled by the JAK–STAT3 pathway? , 2016, Neuroscience.

[47]  E. Goetzl,et al.  Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[48]  H. Weiner,et al.  IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation , 2016, Brain : a journal of neurology.

[49]  J. Cavanagh,et al.  TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain , 2016, Journal of Neuroinflammation.

[50]  K. Engedal,et al.  Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis , 2016, Neuropsychiatric disease and treatment.

[51]  Robert C. Thompson,et al.  Evidence for alterations of the glial syncytial function in major depressive disorder. , 2016, Journal of psychiatric research.

[52]  Andrew H. Miller,et al.  The role of inflammation in depression: from evolutionary imperative to modern treatment target , 2015, Nature Reviews Immunology.

[53]  Baoman Li,et al.  Targeting astrocytes in major depression , 2015, Expert review of neurotherapeutics.

[54]  C. Escartin,et al.  Elusive roles for reactive astrocytes in neurodegenerative diseases , 2015, Front. Cell. Neurosci..

[55]  F. Quintana,et al.  Control of autoimmune CNS inflammation by astrocytes , 2015, Seminars in Immunopathology.

[56]  R. Petersen,et al.  Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study , 2015, Alzheimer's & Dementia.

[57]  Peter B. Jones,et al.  Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. , 2014, JAMA psychiatry.

[58]  Suzana Herculano-Houzel,et al.  The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution , 2014, Glia.

[59]  M. Sofroniew Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators , 2014, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[60]  M. Szyf,et al.  Astrocytic abnormalities and global DNA methylation patterns in depression and suicide , 2014, Molecular Psychiatry.

[61]  J. Cavanagh,et al.  Peripheral inflammation is associated with remote global gene expression changes in the brain , 2014, Journal of Neuroinflammation.

[62]  Sara Hall,et al.  Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment , 2013, Brain, Behavior, and Immunity.

[63]  R. Carson,et al.  The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [11C]PBR28 PET study , 2013, Brain, Behavior, and Immunity.

[64]  G. Rajkowska,et al.  Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. , 2013, Current drug targets.

[65]  Klaus P. Ebmeier,et al.  CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. , 2013, Journal of affective disorders.

[66]  M. Hotopf,et al.  The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis , 2013, Rheumatology.

[67]  I. Losito,et al.  Phospholipidomics of human blood microparticles. , 2013, Analytical chemistry.

[68]  O. Devinsky,et al.  Neuroinflammation and psychiatric illness , 2013, Journal of Neuroinflammation.

[69]  Teruhiko Higuchi,et al.  Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. , 2013, Journal of psychiatric research.

[70]  A. Baker,et al.  A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity , 2012, Brain, Behavior, and Immunity.

[71]  R. Ho,et al.  Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. , 2012, Journal of Affective Disorders.

[72]  B. Barres,et al.  Genomic Analysis of Reactive Astrogliosis , 2012, The Journal of Neuroscience.

[73]  G. Turecki,et al.  Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides , 2011, Neuropsychopharmacology.

[74]  S. Janelidze,et al.  Changes in behaviour and cytokine expression upon a peripheral immune challenge , 2011, Behavioural Brain Research.

[75]  M. Poo,et al.  Grand challenges in global mental health , 2011, Nature.

[76]  Kathryn J. Jones,et al.  IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection , 2011, Brain, Behavior, and Immunity.

[77]  A. Kriegstein,et al.  Developmental genetics of vertebrate glial–cell specification , 2010, Nature.

[78]  Xia Li,et al.  IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes , 2010, The Journal of Immunology.

[79]  E. Erdfelder,et al.  Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses , 2009, Behavior research methods.

[80]  Martin Samuelsson,et al.  Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity , 2009, Biological Psychiatry.

[81]  J. Heinrich,et al.  Relation between stressful life events, neuropeptides and cytokines: results from the LISA birth cohort study , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[82]  N. Sousa,et al.  IL-10 modulates depressive-like behavior. , 2008, Journal of psychiatric research.

[83]  R. Belmaker,et al.  Major depressive disorder. , 2008, The New England journal of medicine.

[84]  B. Jin,et al.  Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo , 2007, Experimental & Molecular Medicine.

[85]  Matthias Egger,et al.  The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies , 2007, PLoS medicine.

[86]  G. Bing,et al.  Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra , 2007, Neurobiology of Aging.

[87]  F. Crews,et al.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration , 2007, Glia.

[88]  D. Gruol,et al.  Physiological and pathological roles of interleukin-6 in the central nervous system , 1997, Molecular Neurobiology.

[89]  J. Falsig,et al.  The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function , 2006, Journal of neurochemistry.

[90]  A. Rosenwald,et al.  BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma , 2005, The Journal of experimental medicine.

[91]  C. Brosnan,et al.  Cytokines: Powerful Regulators of Glial Cell Activation , 2003, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[92]  Paolo Cassano,et al.  Depression and public health: an overview. , 2002, Journal of psychosomatic research.

[93]  Sabine Landau,et al.  Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. , 2002, Cerebral cortex.

[94]  E. Benveniste,et al.  Immune function of astrocytes , 2001, Glia.

[95]  Y. Benjamini,et al.  THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .

[96]  A. Yu,et al.  Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury. , 2001, Journal of neurotrauma.

[97]  J. Levine,et al.  Cerebrospinal Cytokine Levels in Patients with Acute Depression , 1999, Neuropsychobiology.

[98]  Jae-Wook Oh,et al.  Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor , 1999, The Journal of Neuroscience.

[99]  B. Roth,et al.  Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗ ∗ See accompanying Editorial, in this issue. , 1999, Biological Psychiatry.

[100]  J. Price,et al.  Glial reduction in the subgenual prefrontal cortex in mood disorders. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[101]  T. Perneger What's wrong with Bonferroni adjustments , 1998, BMJ.

[102]  J. Philippot,et al.  Asymmetric distribution of phospholipids in the membrane of vesicles released during in vitro maturation of guinea pig reticulocytes: Evidence precluding a role for “aminophospholipid translocase” , 1989, Journal of cellular physiology.

[103]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.