An Image-Based Comprehensive Approach for Automatic Segmentation of Left Ventricle from Cardiac Short Axis Cine MR Images

Segmentation of the left ventricle is important in the assessment of cardiac functional parameters. Manual segmentation of cardiac cine MR images for acquiring these parameters is time-consuming. Accuracy and automation are the two important criteria in improving cardiac image segmentation methods. In this paper, we present a comprehensive approach to segment the left ventricle from short axis cine cardiac MR images automatically. Our method incorporates a number of image processing and analysis techniques including thresholding, edge detection, mathematical morphology, and image filtering to build an efficient process flow. This process flow makes use of various features in cardiac MR images to achieve high accurate segmentation results. Our method was tested on 45 clinical short axis cine cardiac images and the results are compared with manual delineated ground truth (average perpendicular distance of contours near 2 mm and mean myocardium mass overlapping over 90%). This approach provides cardiac radiologists a practical method for an accurate segmentation of the left ventricle.

[1]  Paul F. Whelan,et al.  Segmentation of the Left Ventricle of the Heart in 3-D+t MRI Data Using an Optimized Nonrigid Temporal Model , 2008, IEEE Transactions on Medical Imaging.

[2]  Pau-Choo Chung,et al.  A Fast Algorithm for Multilevel Thresholding , 2001, J. Inf. Sci. Eng..

[3]  Matthew D. Robson,et al.  Cardiovascular Magnetic Resonance: Basic Principles, Methods, and Techniques , 2010 .

[4]  John F. Canny,et al.  A Computational Approach to Edge Detection , 1986, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[5]  Milan Sonka,et al.  Multistage hybrid active appearance model matching: segmentation of left and right ventricles in cardiac MR images , 2001, IEEE Transactions on Medical Imaging.

[6]  Demetri Terzopoulos,et al.  Snakes: Active contour models , 2004, International Journal of Computer Vision.

[7]  Wieslaw Lucjan Nowinski,et al.  A hybrid approach for segmentation of anatomic structures in medical images , 2008, International Journal of Computer Assisted Radiology and Surgery.

[8]  Marcel Breeuwer,et al.  Comprehensive Segmentation of Cine Cardiac MR Images , 2008, MICCAI.

[9]  N. Paragios A level set approach for shape-driven segmentation and tracking of the left ventricle , 2003, IEEE Transactions on Medical Imaging.

[10]  Gerald M. Pohost,et al.  Cardiac CT, PET and MR , 2006 .

[11]  Marie-Pierre Jolly,et al.  Interactive Organ Segmentation Using Graph Cuts , 2000, MICCAI.

[12]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[13]  Wiro J Niessen,et al.  Automatic image‐driven segmentation of the ventricles in cardiac cine MRI , 2008, Journal of magnetic resonance imaging : JMRI.

[14]  Daniel Rueckert,et al.  Segmentation of 4D Cardiac MR Images Using a Probabilistic Atlas and the EM Algorithm , 2003, MICCAI.

[15]  B. Cowan,et al.  Model-based Graph Cut Method for Segmentation of the Left Ventricle , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[16]  I. D. Coope,et al.  Circle fitting by linear and nonlinear least squares , 1993 .

[17]  Alejandro F. Frangi,et al.  Three-dimensional modeling for functional analysis of cardiac images, a review , 2001, IEEE Transactions on Medical Imaging.

[18]  William E. Lorensen,et al.  Marching cubes: A high resolution 3D surface construction algorithm , 1987, SIGGRAPH.

[19]  Alexander Dick,et al.  Segmentation of Left Ventricle in Cardiac Cine MRI: An Automatic Image-Driven Method , 2009, FIMH.

[20]  Boudewijn P. F. Lelieveldt,et al.  A multiresolution image segmentation technique based on pyramidal segmentation and fuzzy clustering , 2000, IEEE Trans. Image Process..

[21]  Boudewijn P. F. Lelieveldt,et al.  Time Continuous Tracking and Segmentation of Cardiovascular Magnetic Resonance Images Using Multidimensional Dynamic Programming , 2006, Investigative radiology.

[22]  Ioannis A. Kakadiaris,et al.  Automated left ventricular segmentation in cardiac MRI , 2006, IEEE Transactions on Biomedical Engineering.

[23]  Jürgen Weese,et al.  Automated segmentation of the left ventricle in cardiac MRI , 2004, Medical Image Anal..