Summary of the conclusions

From this Workshop it became clear that in recent years appreciable improvements in the efficacy and safety of histamine H1 antagonists have been achieved. Also, there has accumulated considerable new knowledge about the mechanisms of action of these drugs, both with respect to their interaction with the H1 receptor and with other cellular components. Amongst these are actions that relate to potential side-effects. The new understanding of molecular mechanisms is likely to provide the basis for further significant improvements in antihistamines as a drug group, through molecular-based design. Until this objective has been realized, the use of the term ‘third-generation’ antihistamine should be abandoned...

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