Noninvasive Brain Stimulation Improves Language Learning

Anodal transcranial direct current stimulation (tDCS) is a reliable technique to improve motor learning. We here wanted to test its potential to enhance associative verbal learning, a skill crucial for both acquiring new languages in healthy individuals and for language reacquisition after stroke-induced aphasia. We applied tDCS (20 min, 1 mA) over the posterior part of the left peri-sylvian area of 19 young right-handed individuals while subjects acquired a miniature lexicon of 30 novel object names. Every subject participated in one session of anodal tDCS, one session of cathodal tDCS, and one sham session in a randomized and double-blinded design with three parallel versions of the miniature lexicon. Outcome measures were learning speed and learning success at the end of each session, and the transfer to the subjects' native language after the respective stimulation. With anodal stimulation, subjects showed faster and better associative learning as compared to sham stimulation. Mood ratings, reaction times, and response styles were comparable between stimulation conditions. Our results demonstrate that anodal tDCS is a promising technique to enhance language learning in healthy adults and may also have the potential to improve language reacquisition after stroke.

[1]  L. Squire,et al.  Structure and function of declarative and nondeclarative memory systems. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Jeffrey W Jutai,et al.  Priorities for stroke rehabilitation and research: results of a 2003 Canadian Stroke Network consensus conference. , 2007, Archives of physical medicine and rehabilitation.

[3]  M. Nitsche,et al.  Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human , 2003, Journal of Cognitive Neuroscience.

[4]  D. Llano,et al.  Biological approaches to aphasia treatment , 2009, Current neurology and neuroscience reports.

[5]  Daniel A Bloch,et al.  A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependence. , 2008, The international journal of neuropsychopharmacology.

[6]  K. H. Britten,et al.  Neuronal plasticity that underlies improvement in perceptual performance. , 1994, Science.

[7]  M. Hallett,et al.  Early consolidation in human primary motor cortex , 2002, Nature.

[8]  M. Nitsche,et al.  Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. , 2002, Brain : a journal of neurology.

[9]  Á. Pascual-Leone,et al.  Enhanced visual spatial attention ipsilateral to rTMS-induced 'virtual lesions' of human parietal cortex , 2001, Nature Neuroscience.

[10]  F. Fregni,et al.  Transcranial direct current stimulation as a therapeutic tool for the treatment of major depression: insights from past and recent clinical studies , 2009, Current opinion in psychiatry.

[11]  Á. Pascual-Leone,et al.  Improved picture naming in chronic aphasia after TMS to part of right Broca’s area: An open-protocol study , 2005, Brain and Language.

[12]  Caterina Breitenstein,et al.  Specific and nonspecific effects of transcranial magnetic stimulation on picture–word verification , 2004, The European journal of neuroscience.

[13]  D. Pandya,et al.  Parietal, temporal, and occipita projections to cortex of the superior temporal sulcus in the rhesus monkey: A retrograde tracer study , 1994, The Journal of comparative neurology.

[14]  Toma S Pauss.  Imaging the brain before \ during \ and after transcranial magnetic stimulation , 2022 .

[15]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[16]  Walter Paulus,et al.  Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects. , 2003, Supplements to Clinical neurophysiology.

[17]  S. Lisanby,et al.  Brain Stimulation in Psychiatry , 2008 .

[18]  L. Cohen,et al.  Efficacy of repetitive transcranial magnetic stimulation/transcranial direct current stimulation in cognitive neurorehabilitation , 2008, Brain Stimulation.

[19]  Á. Pascual-Leone,et al.  Degree of language lateralization determines susceptibility to unilateral brain lesions , 2002, Nature Neuroscience.

[20]  D. Watson,et al.  Development and validation of brief measures of positive and negative affect: the PANAS scales. , 1988, Journal of personality and social psychology.

[21]  Philippe A. Chouinard,et al.  Modulating neural networks with transcranial magnetic stimulation applied over the dorsal premotor and primary motor cortices. , 2003, Journal of neurophysiology.

[22]  M. Folstein,et al.  Reliability, validity, and clinical application of the visual analogue mood scale , 1973, Psychological Medicine.

[23]  Felipe Fregni,et al.  Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females , 2008, Neuroscience Letters.

[24]  M. Hallett,et al.  Improving hand function in chronic stroke. , 2002, Archives of neurology.

[25]  Joseph Classen,et al.  Modulation of use-dependent plasticity by d-amphetamine. , 2002, Annals of neurology.

[26]  R. Gracely.  Pain measurement , 1999, Acta anaesthesiologica Scandinavica.

[27]  Pienie Zwitserlood,et al.  D-Amphetamine Boosts Language Learning Independent of its Cardiovascular and Motor Arousing Effects , 2004, Neuropsychopharmacology.

[28]  L. Cohen,et al.  Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation. , 2004, Journal of neurophysiology.

[29]  R. Töpper,et al.  Facilitation of picture naming after repetitive transcranial magnetic stimulation , 1999, Neurology.

[30]  M. Nitsche,et al.  Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans , 2001, Neurology.

[31]  Stefan Knecht,et al.  Electrical Stimulation of Broca's Area Enhances Implicit Learning of an Artificial Grammar , 2010, Journal of Cognitive Neuroscience.

[32]  J. Donoghue,et al.  Strengthening of horizontal cortical connections following skill learning , 1998, Nature Neuroscience.

[33]  R. Campbell,et al.  Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex , 2000, Current Biology.

[34]  Niels Birbaumer,et al.  Influence of somatosensory input on motor function in patients with chronic stroke , 2004, Annals of neurology.

[35]  Jean-Francois Mangin,et al.  Modulation of language areas with functional MR image-guided magnetic stimulation , 2006, NeuroImage.

[36]  Thomas Wolbers,et al.  Hippocampus activity differentiates good from poor learners of a novel lexicon , 2005, NeuroImage.

[37]  Walter Paulus,et al.  Catecholaminergic consolidation of motor cortical neuroplasticity in humans. , 2004, Cerebral cortex.

[38]  Scott T. Grafton,et al.  Anatomical Substrates of Visual and Auditory Miniature Second-language Learning , 2006, Journal of Cognitive Neuroscience.

[39]  Walter Paulus,et al.  Facilitation of visuo‐motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans , 2004, The European journal of neuroscience.

[40]  A. Jansen,et al.  Word learning can be achieved without feedback: implications for aphasia therapy. , 2004, Restorative neurology and neuroscience.

[41]  Walter Paulus,et al.  Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human , 2004, Neuropsychologia.

[42]  Jacquie Kurland,et al.  Transcranial Magnetic Stimulation as a Complementary Treatment for Aphasia , 2004, Seminars in speech and language.

[43]  Caterina Breitenstein,et al.  Development and validation of a language learning model for behavioral and functional-imaging studies , 2002, Journal of Neuroscience Methods.

[44]  Felipe Fregni,et al.  Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS) , 2009, Neuropsychologia.

[45]  F. M. Mottaghy,et al.  Facilitation of picture naming by focal transcranial magnetic stimulation of Wernicke’s area , 1998, Experimental Brain Research.

[46]  S. Sato,et al.  Safety and cognitive effect of frontal DC brain polarization in healthy individuals , 2005, Neurology.

[47]  L. Cohen,et al.  Transcranial direct current stimulation: State of the art 2008 , 2008, Brain Stimulation.

[48]  E. Ringelstein,et al.  Levodopa: Faster and better word learning in normal humans , 2004, Annals of neurology.

[49]  Sergio P. Rigonatti,et al.  Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory , 2005, Experimental Brain Research.

[50]  M. Nitsche,et al.  GABAergic modulation of DC stimulation‐induced motor cortex excitability shifts in humans , 2004, The European journal of neuroscience.

[51]  Á. Pascual-Leone,et al.  A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. , 2008, The international journal of neuropsychopharmacology.

[52]  J. Krakauer,et al.  Consensus: Can transcranial direct current stimulation and transcranial magnetic stimulation enhance motor learning and memory formation? , 2008, Brain Stimulation.

[53]  R. Töpper,et al.  Repetitive Transcranial Magnetic Stimulation Effects on Language Function Depend on the Stimulation Parameters , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[54]  S. Kirker,et al.  Combined transcranial direct current stimulation and robot-assisted arm training in subacute stroke patients: a pilot study. , 2007, Restorative neurology and neuroscience.

[55]  D. Purpura,et al.  INTRACELLULAR ACTIVITIES AND EVOKED POTENTIAL CHANGES DURING POLARIZATION OF MOTOR CORTEX. , 1965, Journal of neurophysiology.

[56]  Leslie G. Ungerleider,et al.  Functional MRI evidence for adult motor cortex plasticity during motor skill learning , 1995, Nature.

[57]  J. Donoghue,et al.  Long-term potentiation and long-term depression of horizontal connections in rat motor cortex. , 1996, Acta neurobiologiae experimentalis.

[58]  R. Henson,et al.  The neural basis of episodic memory: evidence from functional neuroimaging. , 2002, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[59]  L. Cohen,et al.  Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. , 2005, Brain : a journal of neurology.

[60]  Leonardo G. Cohen,et al.  Recovery of function in humans: Cortical stimulation and pharmacological treatments after stroke , 2010, Neurobiology of Disease.

[61]  C. Price.  The anatomy of language: contributions from functional neuroimaging , 2000, Journal of anatomy.

[62]  S. Knecht,et al.  Tonic Dopaminergic Stimulation Impairs Associative Learning in Healthy Subjects , 2006, Neuropsychopharmacology.

[63]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[64]  G. Dell,et al.  Perseverations and anticipations in aphasia: primed intrusions from the past and future. , 2004, Seminars in speech and language.