Discordance of Diabetic Microangiopathy in Identical Twins

In a pair of 19-year-old monozygotic twin girls, one developed insulin-dependent, ketosis-prone diabetes at the age of three and has required insulin for the past 16 years. Her identical twin has maintained normal oral and intravenous glucose tolerance with normal insulin release and glucagon suppression. An unequivocal hypertrophy of the muscle capillary basement membrane(1,800 ± 148 Å) was found in the diabetic twin, while a normal thickness of 1,149 ± 62 Å was present in her nondiabetic sister. Follow-up of the present subjects and data from other discordant identical twins who have reached adulthood could determine whether muscle capillary basement membrane hypertrophy is an independent marker of genetic diabetes in adults. Discordance of diabetic microangiopathy in a pair of monozygotic twins has important implications regarding the influence of heredity and environment on diabetic microangiopathy.

[1]  K. Johansen,et al.  Serum insulin and growth hormone response patterns in monozygotic twin siblings of patients with juvenile-onset diabetes. , 1975, New England Journal of Medicine.

[2]  T. Maugh.  Diabetes: epidemiology suggests a viral connection. , 1975, Science.

[3]  P. Raskin,et al.  Capillary basement membrane width in diabetic children. , 1975, The American journal of medicine.

[4]  R. Tattersall,et al.  Glucagon secretion in unaffected monozygotic twins of juvenile diabetics. , 1975, Metabolism: clinical and experimental.

[5]  K. Johansen,et al.  Insulin, growth hormone, and glucagon in prediabetes mellitus--a review. , 1974, Metabolism: clinical and experimental.

[6]  M. Bubel,et al.  Assessment of a haemagglutination test for thyroid microsomal antibody. , 1974, Medical laboratory technology.

[7]  E. Fisher,et al.  Capillary basement membranes in muscle in glucose intolerance of the chemical diabetes type. , 1974, American Journal of Clinical Pathology.

[8]  Nicholas Dennis,et al.  The biochemical genetics of man , 1978 .

[9]  J. Gerich,et al.  Stimulation of glucagon secretion by epinephrine in man. , 1973, The Journal of clinical endocrinology and metabolism.

[10]  P. Raskin,et al.  Electron Microscopic Quantification of Diabetic Microangiopathy , 1973, Diabetes.

[11]  P. Raskin,et al.  Hyperlipidemia and diabetes mellitus: can electron microscopy help in the diagnosis. , 1973, The Mount Sinai journal of medicine, New York.

[12]  G. S. Thompson.  Diabetes in identical twins. , 1973, Lancet.

[13]  C. Kilo,et al.  Muscle Capillary Basement Membrane Changes Related to Aging and to Diabetes Mellitus , 1972, Diabetes.

[14]  E. Fisher,et al.  Capillary basement membrane thickness and the pseudodiabetes of myopathy. , 1971, The American journal of medicine.

[15]  D. Pyke,et al.  Glucose Tolerance and Serum Insulin in Identical Twins of Diabetics , 1970, British medical journal.

[16]  Rudolfvracko.  Skeletal Muscle Capillaries in Diabetics , 1970 .

[17]  R. Gleason,et al.  Offspring of two diabetic parents: differential serum insulin responses to intravenous glucose and tolbutamide. , 1969, The Journal of clinical endocrinology and metabolism.

[18]  L S Penrose,et al.  [Memorandum on dermatoglyphic nomenclature]. , 1969, Jinrui idengaku zasshi. The Japanese journal of human genetics.

[19]  E. Ipp,et al.  Ultrastructure of Capillaries in South African Diabetics: II. Muscle Capillaries , 1969, Diabetes.

[20]  G. Grodsky,et al.  Early Phase of Insulin Release , 1968, Diabetes.

[21]  R. Unger,et al.  Studies of muscle capillary basement membranes in normal subjects, diabetic, and prediabetic patients. , 1968, The Journal of clinical investigation.

[22]  K. Lundbaek.  Intravenous Glucose Tolerance as a Tool in Definition and Diagnosis of Diabetes Mellitus* , 1962, British medical journal.

[23]  G. Grodsky,et al.  An immunochemical assay of total extractable insulin in man. , 1960, The Journal of clinical investigation.