Understanding the role topographical features play in stimulating the endogenous peripheral nerve regeneration across critically sized nerve gaps

[1]  A. English,et al.  Thin-film enhanced nerve guidance channels for peripheral nerve repair. , 2009, Biomaterials.

[2]  S. Mackinnon,et al.  The Role of Conduits in Nerve Repair: A Review , 1996, Reviews in the neurosciences.

[3]  Tatsuo Nakamura,et al.  Nerve regeneration across a 25-mm gap bridged by a polyglycolic acid-collagen tube: a histological and electrophysiological evaluation of regenerated nerves , 1996, Brain Research.

[4]  D J Mooney,et al.  Development of biocompatible synthetic extracellular matrices for tissue engineering. , 1998, Trends in biotechnology.

[5]  H M Buettner,et al.  Schwann cell response to micropatterned laminin surfaces. , 2001, Tissue engineering.

[6]  J. Salzer,et al.  Studies of Schwann cell proliferation. II. Characterization of the stimulation and specificity of the response to a neurite membrane fraction , 1980, The Journal of cell biology.

[7]  H. Buettner,et al.  Oriented Schwann Cell Monolayers for Directed Neurite Outgrowth , 2004, Annals of Biomedical Engineering.

[8]  Hanry Yu,et al.  Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. , 2003, Biomaterials.

[9]  M. Shoichet,et al.  Nerve guidance channels as drug delivery vehicles. , 2006, Biomaterials.

[10]  E. Shooter,et al.  The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  B. Schlosshauer,et al.  Strategies for inducing the formation of bands of Büngner in peripheral nerve regeneration. , 2009, Biomaterials.

[12]  X. Wen,et al.  Fabrication of semipermeable hollow fiber membranes with highly aligned texture for nerve guidance. , 2005, Journal of biomedical materials research. Part A.

[13]  E Ruoslahti,et al.  New perspectives in cell adhesion: RGD and integrins. , 1987, Science.

[14]  D. Moratal,et al.  Effect of nanoscale topography on fibronectin adsorption, focal adhesion size and matrix organisation. , 2010, Colloids and surfaces. B, Biointerfaces.

[15]  H. Markram,et al.  Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. , 2009, Nature nanotechnology.

[16]  M. Maltarello,et al.  Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves. , 1996, Biomaterials.

[17]  Patrick Tresco,et al.  Neurite outgrowth on well-characterized surfaces: preparation and characterization of chemically and spatially controlled fibronectin and RGD substrates with good bioactivity. , 2005, Biomaterials.

[18]  Chad Johnson,et al.  The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. , 2004, Biomaterials.

[19]  Shan-hui Hsu,et al.  Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits , 2007, Biomedical microdevices.

[20]  Gabriel A Silva,et al.  Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system. , 2005, Surgical neurology.

[21]  A. Valero-Cabré,et al.  Superior muscle reinnervation after autologous nerve graft or poly‐L‐lactide‐ϵ‐caprolactone (PLC) tube implantation in comparison to silicone tube repair , 2001, Journal of neuroscience research.

[22]  M. Prabhakaran,et al.  Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering. , 2009, Acta biomaterialia.

[23]  Martin Fischer,et al.  Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms , 2006, Neurobiology of Disease.

[24]  Albert Folch,et al.  Integration of topographical and biochemical cues by axons during growth on microfabricated 3-D substrates. , 2005, Experimental cell research.

[25]  R. Eberhart,et al.  Poly(L‐Lactide) microfilaments enhance peripheral nerve regeneration across extended nerve lesions , 2003, Journal of neuroscience research.

[26]  William P King,et al.  Myoblast alignment and differentiation on cell culture substrates with microscale topography and model chemistries. , 2007, Biomaterials.

[27]  A. Berger,et al.  The Interfascicular Nerve-grafting of the Median and Ulnar Nerves , 1972 .

[28]  M. E. Eichler,et al.  The influence of fibronectin and laminin during Schwann cell migration and peripheral nerve regeneration through silicon chambers , 1993, Journal of neurocytology.

[29]  W. Friedman,et al.  The function of p75NTR in glia , 2008, Trends in Neurosciences.

[30]  Göran Lundborg,et al.  Nerve regeneration in silicone chambers: Influence of gap length and of distal stump components , 1982, Experimental Neurology.

[31]  Robert A. Brown,et al.  Cell responses to biomimetic protein scaffolds used in tissue repair and engineering. , 2007, International review of cytology.

[32]  G. Weskamp,et al.  Nerve growth factor and its low-affinity receptor promote Schwann cell migration. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Seeram Ramakrishna,et al.  Design strategies of tissue engineering scaffolds with controlled fiber orientation. , 2007, Tissue engineering.

[34]  Stephanie Bryant,et al.  Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds. , 2008, Biomacromolecules.

[35]  G. Bowlin,et al.  Extracellular matrix regenerated : tissue engineering via electrospun biomimetic nanofibers , 2007 .

[36]  C. Wilkinson,et al.  Making structures for cell engineering. , 2004, European cells & materials.

[37]  A. Höke,et al.  Transfection NCSCsPluripotent stem cells Schwann cells Schwann cells expressing NFs ? ? Adult stem / progenitor cells NF Gradient Proximal end of the damaged nerve Distal end of the damaged nerve Regenerating nerve front , 2011 .

[38]  M. Wiberg,et al.  Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves. , 2002, British journal of plastic surgery.

[39]  S. Wolfe,et al.  Peripheral Nerve Injury and Repair , 2000, The Journal of the American Academy of Orthopaedic Surgeons.

[40]  R Langer,et al.  A tissue-engineered conduit for peripheral nerve repair. , 1998, Archives of otolaryngology--head & neck surgery.

[41]  Lissy K Krishnan,et al.  Development of a fibrin composite-coated poly(epsilon-caprolactone) scaffold for potential vascular tissue engineering applications. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[42]  R. Brown,et al.  Neurotrophin‐3 Delivered Locally via Fibronectin Mats Enhances Peripheral Nerve Regeneration , 1997, The European journal of neuroscience.

[43]  R. Bellamkonda,et al.  Lipid-based microtubular drug delivery vehicles. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[44]  Masanori Oka,et al.  30 mm regeneration of rat sciatic nerve along collagen filaments , 2002, Brain Research.

[45]  R. Midha,et al.  Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. , 1998, The Journal of trauma.

[46]  J. Corbett,et al.  Expression of Neuregulins and their Putative Receptors, ErbB2 and ErbB3, Is Induced during Wallerian Degeneration , 1997, The Journal of Neuroscience.

[47]  J. Vacanti,et al.  A new artificial nerve graft containing rolled Schwann cell monolayers , 2001, Microsurgery.

[48]  Jonathan V Selinger,et al.  Diacetylenic Lipid Tubules: Experimental Evidence for a Chiral Molecular Architecture , 1994, Science.

[49]  Rajiv Midha,et al.  Peripheral nerve regeneration through a synthetic hydrogel nerve tube. , 2005, Restorative neurology and neuroscience.

[50]  R. Timpl,et al.  In vivo and in vitro observations on laminin production by Schwann cells. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Peter M Vogt,et al.  Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit , 2006, Journal of cellular and molecular medicine.

[52]  F H Silver,et al.  Collagen fibrillogenesis in vitro: comparison of types I, II, and III. , 1984, Archives of biochemistry and biophysics.

[53]  Fabrizio Gelain,et al.  Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections , 2008, BMC biotechnology.

[54]  Mingyong Gao,et al.  Precision microchannel scaffolds for central and peripheral nervous system repair , 2011, Journal of materials science. Materials in medicine.

[55]  E. Shooter,et al.  Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Raff,et al.  Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve , 1979, Brain Research.

[57]  D. Seliktar,et al.  Compositional alterations of fibrin-based materials for regulating in vitro neural outgrowth. , 2008, Tissue engineering. Part A.

[58]  B. Rosén,et al.  Tubular Repair of the Median or Ulnar Nerve in the Human Forearm: A 5-Year Follow-Up , 2004, Journal of hand surgery.

[59]  H. M. Liu The role of extracellular matrix in peripheral nerve regeneration: a wound chamber study , 2004, Acta Neuropathologica.

[60]  Lars Montelius,et al.  Axonal outgrowth on nano-imprinted patterns. , 2006, Biomaterials.

[61]  Samuel I Stupp,et al.  Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofibers by soft lithography. , 2007, Nano letters.

[62]  R. Brown,et al.  Nerve guide material made from fibronectin: assessment of in vitro properties. , 2003, Tissue engineering.

[63]  Marcello Imbriani,et al.  Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines. , 2011, Biomacromolecules.

[64]  A Curtis,et al.  Topographical control of cells. , 1997, Biomaterials.

[65]  A. Shin,et al.  Treatment of a segmental nerve defect in the rat with use of bioabsorbable synthetic nerve conduits: a comparison of commercially available conduits. , 2009, The Journal of bone and joint surgery. American volume.

[66]  Anderson,et al.  Host response to tissue engineered devices. , 1998, Advanced drug delivery reviews.

[67]  J. Golding,et al.  Effects of Extracellular Matrix Components on Axonal Outgrowth from Peripheral Nerves of Adult Animalsin Vitro , 1997, Experimental Neurology.

[68]  C. Schmidt,et al.  Engineering strategies for peripheral nerve repair. , 1999, The Orthopedic clinics of North America.

[69]  M. Salmerón-Sánchez,et al.  Biological activity of the substrate-induced fibronectin network: insight into the third dimension through electrospun fibers. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[70]  N. Kleitman,et al.  Axonal regeneration into Schwann cell‐seeded guidance channels grafted into transected adult rat spinal cord , 1995, The Journal of comparative neurology.

[71]  Peter X Ma,et al.  Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. , 2003, Journal of biomedical materials research. Part A.

[72]  A. Ansselin,et al.  Axonal regeneration through peripheral nerve grafts: The effect of proximo‐distal orientation , 1988, Microsurgery.

[73]  C. Woolf,et al.  The neuropathic pain triad: neurons, immune cells and glia , 2007, Nature Neuroscience.

[74]  Xiaojun Yu,et al.  Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps. , 2003, Tissue engineering.

[75]  P Weiss,et al.  SCIENTIFIC APPARATUS AND LABORATORY METHODS. REUNION OF STUMPS OF SMALL NERVES BY TABULATION INSTEAD OF SUTURES , 1945 .

[76]  M. Horne,et al.  Review Paper: A Review of the Cellular Response on Electrospun Nanofibers for Tissue Engineering , 2009, Journal of biomaterials applications.

[77]  R. Langer,et al.  Engineering substrate topography at the micro- and nanoscale to control cell function. , 2009, Angewandte Chemie.

[78]  Dietmar W Hutmacher,et al.  Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. , 2008, Biomacromolecules.

[79]  L. Ghasemi‐Mobarakeh,et al.  Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. , 2008, Biomaterials.

[80]  Wei Wang,et al.  Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration. , 2009, Journal of biomedical materials research. Part A.

[81]  Cato T Laurencin,et al.  Electrospun nanofibrous structure: a novel scaffold for tissue engineering. , 2002, Journal of biomedical materials research.

[82]  A. English,et al.  Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation , 2005, Experimental Neurology.

[83]  G. Comi,et al.  The extracellular matrix affects axonal regeneration in peripheral neuropathies , 2008, Neurology.

[84]  H. Kleinman,et al.  Fibronectin promotes rat Schwann cell growth and motility. , 1982 .

[85]  W. Bonfield,et al.  In vitro and in vivo evaluation of polyhydroxybutyrate and of polyhydroxybutyrate reinforced with hydroxyapatite. , 1991, Biomaterials.

[86]  Christine E Schmidt,et al.  Effects of collagen 1, fibronectin, laminin and hyaluronic acid concentration in multi-component gels on neurite extension , 2007, Journal of biomaterials science. Polymer edition.

[87]  R. Bellamkonda,et al.  Sustained release of plasmid DNA using lipid microtubules and agarose hydrogel. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[88]  G. Evans,et al.  Challenges to nerve regeneration. , 2000, Seminars in surgical oncology.

[89]  T. Olsson,et al.  Peripheral nerve injury induces endoneurial expression of IFN-gamma, IL-10 and TNF-alpha mRNA. , 2000, Journal of neuroimmunology.

[90]  Xavier Navarro,et al.  Magnetically Aligned Collagen Gel Filling a Collagen Nerve Guide Improves Peripheral Nerve Regeneration , 1999, Experimental Neurology.

[91]  D. Sierra,et al.  Brain-derived neurotrophic factor and collagen tubulization enhance functional recovery after peripheral nerve transection and repair. , 1996, Archives of otolaryngology--head & neck surgery.

[92]  A. Lejeune,et al.  Sciatic Nerve Regeneration through Venous or Nervous Grafts in the Rat , 1997, Experimental Neurology.

[93]  M. Shoichet,et al.  Peripheral nerve regeneration through guidance tubes , 2004, Neurological research.

[94]  G. Lundborg,et al.  A Role of Migratory Schwann Cells in a Conditioning Effect of Peripheral Nerve Regeneration , 1999, Experimental Neurology.

[95]  J. Salzer,et al.  Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury , 1980, The Journal of cell biology.

[96]  Xiaosong Gu,et al.  Biocompatibility evaluation of silk fibroin with peripheral nerve tissues and cells in vitro. , 2007, Biomaterials.

[97]  James N. Campbell,et al.  Complications from silicon‐polymer intubulation of nerves , 1989, Microsurgery.

[98]  J. A. Cooper,et al.  Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. , 2006, Acta biomaterialia.

[99]  A. Goldstein,et al.  Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. , 2006, Biomaterials.

[100]  Cheryl Miller,et al.  Synergistic effects of physical and chemical guidance cues on neurite alignment and outgrowth on biodegradable polymer substrates. , 2002, Tissue engineering.

[101]  Yasuhiko Tabata,et al.  Tissue regeneration based on growth factor release. , 2003, Tissue engineering.

[102]  Ravi V Bellamkonda,et al.  The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. , 2008, Biomaterials.

[103]  Charles Tator,et al.  Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube. , 2003, Journal of neurosurgery.

[104]  T. Gordon,et al.  Chronic Schwann Cell Denervation and the Presence of a Sensory Nerve Reduce Motor Axonal Regeneration , 2002, Experimental Neurology.

[105]  Ravi V Bellamkonda,et al.  Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. , 2008, Biomaterials.

[106]  Xiaojun Yu,et al.  Novel nanofibrous spiral scaffolds for neural tissue engineering , 2008, Journal of neural engineering.

[107]  Qingfeng Li,et al.  Nerve conduit filled with GDNF gene‐modified schwann cells enhances regeneration of the peripheral nerve , 2006, Microsurgery.

[108]  M. Wiberg,et al.  New Fibrin Conduit for Peripheral Nerve Repair , 2008, Journal of reconstructive microsurgery.

[109]  Doris Klee,et al.  Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-epsilon-caprolactone and a collagen/poly-epsilon-caprolactone blend. , 2007, Biomaterials.

[110]  W. Nix,et al.  Electrical stimulation of regenerating nerve and its effect on motor recovery , 1983, Brain Research.

[111]  J. Vega,et al.  Expression of the cytoskeletal protein MAP5 and its regulation by neurotrophin 3 (NT3) in the inner ear sensory neurons , 1997, Anatomy and Embryology.

[112]  Yoshito Ikada,et al.  Creating bioabsorbable Schwann cell coated conduits through tissue engineering. , 2003, Bio-medical materials and engineering.

[113]  W. Tian,et al.  Improvement of peripheral nerve regeneration by a tissue-engineered nerve filled with ectomesenchymal stem cells. , 2007, International journal of oral and maxillofacial surgery.

[114]  Stefano Geuna,et al.  Evaluation of two biodegradable nerve guides for the reconstruction of the rat sciatic nerve. , 2007, Bio-medical materials and engineering.

[115]  R F Valentini,et al.  Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels. , 1991, Biomaterials.

[116]  Mikael Wiberg,et al.  Effect of Allogeneic Schwann Cell Transplantation on Peripheral Nerve Regeneration , 2002, Experimental Neurology.

[117]  S. Rotshenker Wallerian degeneration: the innate-immune response to traumatic nerve injury , 2011, Journal of Neuroinflammation.

[118]  D. Moratal,et al.  Substrate-induced assembly of fibronectin into networks: influence of surface chemistry and effect on osteoblast adhesion. , 2009, Tissue engineering. Part A.

[119]  Tessa Gordon,et al.  Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression , 2007, Experimental Neurology.

[120]  Yen Wei,et al.  Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts , 2006, Journal of biomaterials science. Polymer edition.

[121]  C. Krarup,et al.  Monkey median nerve repaired by nerve graft or collagen nerve guide tube , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[122]  M. Spector,et al.  Collagen-GAG Substrate Enhances the Quality of Nerve Regeneration through Collagen Tubes up to Level of Autograft , 1998, Experimental Neurology.

[123]  A. English,et al.  Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling , 2007, Developmental neurobiology.

[124]  R. Martini,et al.  Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease , 2008, Glia.

[125]  J. Salzer,et al.  Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen , 1980, The Journal of cell biology.

[126]  Seeram Ramakrishna,et al.  Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering. , 2008, Tissue engineering. Part A.

[127]  K. Thompson,et al.  Pharmacokinetics and Biodistribution of Novel Aptamer Compositions , 2004, Pharmaceutical Research.

[128]  Andrés J. García,et al.  Role of fibronectin in topographical guidance of neurite extension on electrospun fibers. , 2011, Biomaterials.

[129]  G. F. Walter,et al.  Bridging Extended Nerve Defects with an Artifcial Nerve Graft Containing Schwann Cells Pre-Seeded on Polyglactin Filaments , 2007, The International journal of artificial organs.

[130]  Toshihiro Akaike,et al.  A novel degradable polycaprolactone networks for tissue engineering. , 2003, Biomaterials.

[131]  M. Wiberg,et al.  A composite poly‐hydroxybutyrate–glial growth factor conduit for long nerve gap repairs , 2003, Journal of anatomy.

[132]  D. Brunette,et al.  Effects of substratum surface topography on the organization of cells and collagen fibers in collagen gel cultures. , 2002, Journal of biomedical materials research.

[133]  R. Bellamkonda,et al.  Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury , 2009, Proceedings of the National Academy of Sciences.

[134]  G. Lundborg,et al.  The use of silicone tubing in the late repair of the median and ulnar nerves in the forearm. , 2001, Journal of hand surgery.

[135]  J. Trotter,et al.  STEM/TEM studies of collagen fibril assembly. , 2001, Micron.

[136]  P. Tresco,et al.  Contact guidance induced organization of extracellular matrix. , 2004, Biomaterials.

[137]  Yong Yang,et al.  Nanoscale surfacing for regenerative medicine. , 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[138]  P. M. Galletti,et al.  Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump , 1988, Brain Research.

[139]  Rajiv Midha,et al.  Emerging techniques for nerve repair: nerve transfers and nerve guidance tubes. , 2006, Clinical neurosurgery.

[140]  Seeram Ramakrishna,et al.  Electrospun poly(L-lactide-co-glycolide) biodegradable polymer nanofibre tubes for peripheral nerve regeneration , 2004 .

[141]  S. Bowald,et al.  Regeneration of peripheral nerve through a polyglactin tube , 1982, Muscle & nerve.

[142]  G. Weddell Axonal regeneration in cutaneous nerve plexuses. , 1943, Journal of anatomy.

[143]  D. F. Davey,et al.  Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells , 1997, Neuropathology and applied neurobiology.

[144]  J. Terzis,et al.  Historical and Basic Science Review: Past, Present, and Future of Nerve Repair , 1997, Journal of reconstructive microsurgery.

[145]  B. Hempstead Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[146]  M. Oka,et al.  Collagen filaments as a scaffold for nerve regeneration. , 2001, Journal of biomedical materials research.

[147]  G. Lundborg,et al.  Repair of the transected rat sciatic nerve: matrix formation within implanted silicone tubes. , 1993, Restorative neurology and neuroscience.

[148]  Ida K. Fox,et al.  Effects of motor versus sensory nerve grafts on peripheral nerve regeneration , 2004, Experimental Neurology.

[149]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[150]  C. Schmidt,et al.  Neuroactive conducting scaffolds: nerve growth factor conjugation on active ester-functionalized polypyrrole , 2009, Journal of The Royal Society Interface.

[151]  Michiya Matsusaki,et al.  Fabrication of cellular multilayers with nanometer-sized extracellular matrix films. , 2007, Angewandte Chemie.

[152]  R. Giardino,et al.  Guided regeneration with resorbable conduits in experimental peripheral nerve injuries , 2000, International Orthopaedics.

[153]  E. Shooter,et al.  Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[154]  Benjamin G Keselowsky,et al.  Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding. , 2004, Biomaterials.

[155]  Surya K Mallapragada,et al.  Directed growth and selective differentiation of neural progenitor cells on micropatterned polymer substrates. , 2006, Biomaterials.

[156]  Yen Wei,et al.  Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. , 2006, Biomaterials.

[157]  J. Vacanti,et al.  A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. , 2000, Tissue engineering.

[158]  S. Varon,et al.  Modification of fibrin matrix formation in situ enhances nerve regeneration in silicone chambers , 1985, The Journal of comparative neurology.

[159]  R. Bellamkonda,et al.  Tissue Engineering Strategies Designed to Realize the Endogenous Regenerative Potential of Peripheral Nerves , 2009 .

[160]  P. Thanos,et al.  Ultrastructure and Cellular Biology of Nerve Regeneration , 1998, Journal of reconstructive microsurgery.

[161]  H. Kleinman,et al.  Synthesis and effects of basement membrane components in cultured rat Schwann cells. , 1984, Developmental biology.

[162]  G. Lundborg,et al.  Ulnar nerve repair by the silicone chamber technique. Case report. , 1991, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[163]  Surya K Mallapragada,et al.  Synergistic effects of micropatterned biodegradable conduits and Schwann cells on sciatic nerve regeneration , 2004, Journal of neural engineering.

[164]  Xuejun Peng,et al.  Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. , 2005, Journal of biomedical materials research. Part A.

[165]  B. Schlosshauer,et al.  Synthetic Nerve Guide Implants in Humans: A Comprehensive Survey , 2006, Neurosurgery.

[166]  Y. Koyama,et al.  Enhancement of peripheral nerve regeneration using bioabsorbable polymer tubes packed with fibrin gel. , 2007, Artificial organs.

[167]  M. Prabhakaran,et al.  Nanotechnology for nanomedicine and delivery of drugs. , 2008, Current pharmaceutical design.

[168]  Guoping Chen,et al.  Cellular control of tissue architectures using a three-dimensional tissue fabrication technique. , 2007, Biomaterials.

[169]  M Cronin-Golomb,et al.  Surface organization and nanopatterning of collagen by dip-pen nanolithography , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[170]  M. Constantinescu,et al.  Effects of local continuous release of brain derived neurotrophic factor (BDNF) on peripheral nerve regeneration in a rat model , 2006, Experimental Neurology.

[171]  M. Oka,et al.  Peripheral nerve regeneration along collagen filaments , 2001, Brain Research.

[172]  K. Akassoglou,et al.  Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice , 2003, Neuroscience Letters.

[173]  L. Williams,et al.  Exogenous fibrin matrix precursors stimulate the temporal progress of nerve regeneration within a silicone chamber , 1987, Neurochemical Research.

[174]  R. Bellamkonda,et al.  The use of lipid microtubes as a novel slow‐release delivery system for laryngeal injection , 2011, The Laryngoscope.

[175]  T Gordon,et al.  Brief Electrical Stimulation Promotes the Speed and Accuracy of Motor Axonal Regeneration , 2000, The Journal of Neuroscience.

[176]  B. Nebe,et al.  Control of focal adhesion dynamics by material surface characteristics. , 2005, Biomaterials.

[177]  G. Cavallaro,et al.  Autogenous Vein and Nerve Grafts: A Comparative Study of Nerve Regeneration in the Rat , 1989, Journal of hand surgery.

[178]  R. Bhat,et al.  Why Is Trehalose an Exceptional Protein Stabilizer? , 2003, Journal of Biological Chemistry.

[179]  R. Brown,et al.  Adhesion, alignment, and migration of cultured Schwann cells on ultrathin fibronectin fibres. , 1999, Cell motility and the cytoskeleton.

[180]  D. Burke,et al.  A topical mixture for preventing, abolishing, and treating autophagia and self-mutilation in laboratory rats. , 2001, Contemporary topics in laboratory animal science.

[181]  G. Keilhoff,et al.  Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cells. , 2006, European journal of cell biology.

[182]  M. Wiberg,et al.  A resorbable nerve conduit as an alternative to nerve autograft in nerve gap repair. , 1999, British journal of plastic surgery.

[183]  S T Li,et al.  A collagen‐based nerve guide conduit for peripheral nerve repair: An electrophysiological study of nerve regeneration in rodents and nonhuman primates , 1991, The Journal of comparative neurology.

[184]  D. Muir,et al.  Chondroitin sulfate proteoglycan with neurite-inhibiting activity is up-regulated following peripheral nerve injury. , 1998, Journal of neurobiology.

[185]  J. Fawcett,et al.  Division of labor of Schwann cell integrins during migration on peripheral nerve extracellular matrix ligands. , 1997, Developmental biology.

[186]  J. L. Seifert,et al.  Peripheral Nerve Repair Through Multi-Luminal Biosynthetic Implants , 2011, Annals of Biomedical Engineering.

[187]  H. K. Tuttle EXPOSURE OF THE BRACHIAL PLEXUS WITH NERVE-TRANSPLANTATION , 1913 .

[188]  H. Sawada,et al.  Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats. , 2004, Journal of neurosurgery.

[189]  S. Ramakrishna,et al.  In vivo study of novel nanofibrous intra-luminal guidance channels to promote nerve regeneration , 2010, Journal of neural engineering.

[190]  G Lundborg,et al.  Bioartificial nerve graft for bridging extended nerve defects in rat sciatic nerve based on resorbable guiding filaments. , 2000, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[191]  Kam W Leong,et al.  Sustained release of proteins from electrospun biodegradable fibers. , 2005, Biomacromolecules.

[192]  G. Lundborg,et al.  Competence of nerve tissue as distal insert promoting nerve regeneration in a silicone chamber , 1984, Brain Research.

[193]  J. Schnur,et al.  Lipid Tubules: A Paradigm for Molecularly Engineered Structures , 1993, Science.

[194]  Vivek Mukhatyar,et al.  Advances in bioengineered conduits for peripheral nerve regeneration. , 2011, Atlas of the oral and maxillofacial surgery clinics of North America.

[195]  R V Bellamkonda,et al.  The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold. , 1998, Journal of biomaterials science. Polymer edition.

[196]  Don L. Jewett,et al.  Nerve repair and regeneration : its clinical and experimental basis , 1980 .

[197]  M. Saarma,et al.  Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons , 1997, Cell and Tissue Research.

[198]  R. Ambron,et al.  Histologic analysis of Schwann cell migration and peripheral nerve regeneration in the autogenous venous nerve conduit (AVNC). , 2003, Journal of reconstructive microsurgery.

[199]  Wei Liu,et al.  Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration. , 2007, Biomaterials.

[200]  Shiao-Wen Tsai,et al.  Growth of Mesenchymal Stem Cells on Electrospun Type I Collagen Nanofibers , 2006, Stem cells.

[201]  Kam W Leong,et al.  The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. , 2008, Biomaterials.

[202]  C. Vieu,et al.  Fabrication of planar cobalt electrodes separated by a sub-10nm gap using high resolution electron beam lithography with negative PMMA. , 2007, Ultramicroscopy.

[203]  H. Horie,et al.  Oxidized Galectin‐1 Stimulates the Migration of Schwann Cells from Both Proximal and Distal Stumps of Transected Nerves and Promotes Axonal Regeneration after Peripheral Nerve Injury , 2003, Journal of neuropathology and experimental neurology.

[204]  X. Cao,et al.  Defining the concentration gradient of nerve growth factor for guided neurite outgrowth , 2001, Neuroscience.

[205]  A. Narakas Thoughts on neurotization or nerve transfers in irreparable nerve lesions. , 1984, Clinics in Plastic Surgery.

[206]  D. Wise,et al.  Enhanced Peripheral Nerve Regeneration Elicited by Cell-Mediated Events Delivered via a Bioresorbable PLGA Guide , 2003, Journal of reconstructive microsurgery.

[207]  A. Farini,et al.  Skin‐derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection , 2007, Glia.

[208]  Diane Hoffman-Kim,et al.  Topography, cell response, and nerve regeneration. , 2010, Annual review of biomedical engineering.

[209]  Richard E. Coggeshall,et al.  Nerve regeneration through holey silicone tubes , 1985, Brain Research.

[210]  C. Patrick,et al.  In vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration. , 1999, Biomaterials.

[211]  J. Kohn,et al.  Carbon Nanotube Fibers Are Compatible With Mammalian Cells and Neurons , 2008, IEEE Transactions on NanoBioscience.

[212]  Göran Lundborg,et al.  Spatial‐Temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay , 1983, The Journal of comparative neurology.

[213]  R. Midha,et al.  Collagen nerve conduits promote enhanced axonal regeneration, schwann cell association, and neovascularization compared to silicone conduits. , 2009, Tissue engineering. Part A.

[214]  M. Raghunath,et al.  Electro-spinning of pure collagen nano-fibres - just an expensive way to make gelatin? , 2008, Biomaterials.

[215]  V. Parpura,et al.  Applications of Carbon Nanotubes in Neurobiology , 2007, Neurodegenerative Diseases.

[216]  P. Aebischer,et al.  The morphology of regenerating peripheral nerves is modulated by the surface microgeometry of polymeric guidance channels , 1990, Brain Research.

[217]  Stephen Britland,et al.  Morphogenetic guidance cues can interact synergistically and hierarchically in steering nerve cell growth , 1996 .

[218]  S. Kim,et al.  Peripheral Nerve Regeneration Using a Three Dimensionally Cultured Schwann Cell Conduit , 2007, The Journal of craniofacial surgery.

[219]  C. Zhang,et al.  Early Spatiotemporal Progress of Myelinated Nerve Fiber Regenerating through Biological Chitin Conduit after Injury , 2010, Artificial cells, blood substitutes, and immobilization biotechnology.

[220]  Krista L. Niece,et al.  Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers , 2004, Science.

[221]  J. Hubbell,et al.  Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. , 2005, Journal of neurobiology.

[222]  Roy M. Smeal,et al.  Substrate Curvature Influences the Direction of Nerve Outgrowth , 2005, Annals of Biomedical Engineering.

[223]  N. Danielsen,et al.  Exogenous matrix precursors promote functional nerve regeneration across a 15‐mm gap within a silicone chamber in the rat , 1987, The Journal of comparative neurology.

[224]  M. Wiberg,et al.  A New Resorbable Wrap-Around Implant as an Alternative Nerve Repair Technique , 1999, Journal of hand surgery.