Lactate Dyscrasia: a Novel Explanation for Amyotrophic Lateral Sclerosis

[1]  John McAnally,et al.  MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice , 2009, Science.

[2]  R. Pasterkamp,et al.  Axon guidance proteins: Novel therapeutic targets for ALS? , 2009, Progress in Neurobiology.

[3]  M. Schwartz,et al.  Thymic involution, a co-morbidity factor in amyotrophic lateral sclerosis , 2009, Journal of cellular and molecular medicine.

[4]  G. Mora,et al.  Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process , 2009, Journal of Neuroimmunology.

[5]  C. Atwood,et al.  Opioid and progesterone signaling is obligatory for early human embryogenesis. , 2009, Stem cells and development.

[6]  Silvia Mangia,et al.  The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation , 2009, Journal of neurochemistry.

[7]  L. Schaeffer,et al.  Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons , 2009, PloS one.

[8]  T. Raju,et al.  Cerebrospinal Fluid from sporadic Amyotrophic Lateral Sclerosis patients induces degeneration of a cultured motor neuron cell line , 2009, Brain Research.

[9]  T. Gordon,et al.  Progressive motor unit loss in the G93A mouse model of amyotrophic lateral sclerosis is unaffected by gender , 2009, Muscle & nerve.

[10]  Janice Rymer,et al.  The role of androgens , 2008 .

[11]  C. Svendsen,et al.  Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[12]  L. Pellerin.  Brain energetics (thought needs food) , 2008, Current opinion in clinical nutrition and metabolic care.

[13]  Y. Mali,et al.  Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase , 2008, Neurobiology of Disease.

[14]  C. Atwood,et al.  Reproductive hormones regulate the selective permeability of the blood-brain barrier. , 2008, Biochimica et biophysica acta.

[15]  B. Gwag,et al.  Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice , 2008, Journal of Neurological Sciences.

[16]  J. Leiter,et al.  Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte–Neuron Lactate-Shuttle Hypothesis , 2008, The Journal of Neuroscience.

[17]  C. Svendsen,et al.  Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis , 2008, Trends in Neurosciences.

[18]  T. Holmøy,et al.  T cells in amyotrophic lateral sclerosis , 2008, European journal of neurology.

[19]  R. Oppenheim,et al.  Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis , 2007, The Journal of Neuroscience.

[20]  T. Gordon,et al.  Time course of preferential motor unit loss in the SOD1G93A mouse model of amyotrophic lateral sclerosis , 2007, Neurobiology of Disease.

[21]  P. Leigh,et al.  Clinical care of patients with amyotrophic lateral sclerosis , 2007, The Lancet Neurology.

[22]  F. Muller,et al.  Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[23]  C. Svendsen,et al.  GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS , 2007, PloS one.

[24]  A. Echaniz-Laguna,et al.  Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model , 2007, The Journal of Neuroscience.

[25]  T. Raju,et al.  Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients , 2007, Journal of the Neurological Sciences.

[26]  A. Parsadanian,et al.  Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS , 2007, Experimental Neurology.

[27]  I. Ionov.  Survey of ALS‐associated factors potentially promoting Ca2+ overload of motor neurons , 2007, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[28]  E. Beghi,et al.  The epidemiology of ALS and the role of population-based registries. , 2006, Biochimica et biophysica acta.

[29]  F. Gage,et al.  Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis , 2006, Proceedings of the National Academy of Sciences.

[30]  M. Schwab,et al.  The neurite outgrowth inhibitor Nogo‐A promotes denervation in an amyotrophic lateral sclerosis model , 2006, EMBO reports.

[31]  Robert H. Brown,et al.  Molecular biology of amyotrophic lateral sclerosis: insights from genetics , 2006, Nature Reviews Neuroscience.

[32]  George Perry,et al.  Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. , 2006, Biochimica et biophysica acta.

[33]  F. Andrade,et al.  Lactate is a metabolic substrate that sustains extraocular muscle function , 2006, Pflügers Archiv.

[34]  G. Hoogland,et al.  Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients , 2006, Neurochemistry International.

[35]  Lei Liu,et al.  Rapid inhibitory effect of glucocorticoids on airway smooth muscle contractions in guinea pigs , 2006, Steroids.

[36]  O. Uchitel,et al.  Testosterone modulates Cav2.2 calcium channels’ functional expression at rat levator ani neuromuscular junction , 2005, Neuroscience.

[37]  M. Behan,et al.  Sex hormone receptors are expressed in identified respiratory motoneurons in male and female rats , 2005, Neuroscience.

[38]  Dongxian Zhang,et al.  Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model , 2005, The European journal of neuroscience.

[39]  P. Shaw,et al.  Molecular and cellular pathways of neurodegeneration in motor neurone disease , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[40]  A Al-Chalabi,et al.  Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET. , 2005, Brain : a journal of neurology.

[41]  J. Glass,et al.  The Wld S gene modestly prolongs survival in the SOD1G93A fALS mouse , 2005, Neurobiology of Disease.

[42]  M. Lupi,et al.  Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells , 2005, Journal of the Neurological Sciences.

[43]  Mari Yoshida,et al.  α-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy , 2005, Acta Neuropathologica.

[44]  R. Brinton,et al.  The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression , 2005, The Journal of Neuroscience.

[45]  M. Beal,et al.  Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice , 2005, The Journal of Neuroscience.

[46]  A. Harvey,et al.  Androgens, andropause and neurodegeneration: exploring the link between steroidogenesis, androgens and Alzheimer's disease. , 2005, Cellular and molecular life sciences : CMLS.

[47]  J. Simpkins,et al.  Estrogens, progestins, menopause and neurodegeneration: basic and clinical studies. , 2005, Cellular and molecular life sciences : CMLS.

[48]  Sterling C. Johnson,et al.  Neuroprotective effects of female sex steroids in humans: current controversies and future directions. , 2005, Cellular and molecular life sciences : CMLS.

[49]  Mark A. Smith,et al.  Dysregulation of the Hypothalamic-Pituitary-Gonadal Axis with Menopause and Andropause Promotes Neurodegenerative Senescence , 2005, Journal of neuropathology and experimental neurology.

[50]  C. Atwood,et al.  The role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain. , 2005, Cellular and molecular life sciences : CMLS.

[51]  S. Yang,et al.  Alzheimer’s disease: the impact of age-related changes in reproductive hormones , 2005, Cellular and Molecular Life Sciences CMLS.

[52]  Clovis Rakotoarivelo,et al.  Receptors to Steroid Hormones and Aromatase Are Expressed by Cultured Motoneurons but Not by Glial Cells Derived from Rat Embryo Spinal Cord , 2005, Neuroendocrinology.

[53]  A. Musarò,et al.  Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model , 2005, The Journal of cell biology.

[54]  W. Wang,et al.  Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) , 2004, Neuroscience.

[55]  L. Barbeito,et al.  A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis , 2004, Brain Research Reviews.

[56]  H. Scheich,et al.  Age-dependent changes in MRI of motor brain stem nuclei in a mouse model of ALS , 2004, Neuroreport.

[57]  C. Atwood,et al.  Living and Dying for Sex , 2004, Gerontology.

[58]  S. Landau,et al.  Cortical selective vulnerability in motor neuron disease: a morphometric study. , 2004, Brain : a journal of neurology.

[59]  C. Jordan,et al.  Androgen receptor immunoreactivity in skeletal muscle: Enrichment at the neuromuscular junction , 2004, The Journal of comparative neurology.

[60]  R. Martins,et al.  Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-β Precursor Protein and Amyloid-β Deposition* , 2004, Journal of Biological Chemistry.

[61]  F. Turkheimer,et al.  Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study , 2004, Neurobiology of Disease.

[62]  T. Gordon,et al.  Adaptive and maladaptive motor axonal sprouting in aging and motoneuron disease , 2004, Neurological research.

[63]  M. Weiner,et al.  17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions. , 2004, Archives of neurology.

[64]  J. Glass,et al.  Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man , 2004, Experimental Neurology.

[65]  A. Hays,et al.  Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis , 2004, Journal of the Neurological Sciences.

[66]  B. Bhavnani,et al.  Equine Estrogens Differentially Prevent Neuronal Cell Death Induced by Glutamate , 2003, The Journal of the Society for Gynecologic Investigation: JSGI.

[67]  G. Forster,et al.  Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS , 2003, Neurology.

[68]  J. Sanes,et al.  Inhibiting Axon Degeneration and Synapse Loss Attenuates Apoptosis and Disease Progression in a Mouse Model of Motoneuron Disease , 2003, Current Biology.

[69]  C. Léránth,et al.  Gonadal Hormones Affect Spine Synaptic Density in the CA1 Hippocampal Subfield of Male Rats , 2003, The Journal of Neuroscience.

[70]  Zuoshang Xu,et al.  Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis , 2002, Journal of neurochemistry.

[71]  Naoyuki Taniguchi,et al.  Dorfin Ubiquitylates Mutant SOD1 and Prevents Mutant SOD1-mediated Neurotoxicity* , 2002, The Journal of Biological Chemistry.

[72]  M. Beal,et al.  Mutated Human SOD1 Causes Dysfunction of Oxidative Phosphorylation in Mitochondria of Transgenic Mice* , 2002, The Journal of Biological Chemistry.

[73]  Lixia Zhao,et al.  Neuroprotective and Neurotrophic Efficacy of Phytoestrogens in Cultured Hippocampal Neurons , 2002, Experimental biology and medicine.

[74]  C. Léránth,et al.  Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal subfield of female nonhuman primates , 2002, The Journal of comparative neurology.

[75]  S. Al-Sarraj,et al.  Ubiquitin‐only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia , 2002, Neuropathology and applied neurobiology.

[76]  V. Bella,et al.  The serum level of free testosterone is reduced in amyotrophic lateral sclerosis , 2002, Journal of the Neurological Sciences.

[77]  Zuoshang Xu,et al.  A quantitative histochemical assay for activities of mitochondrial electron transport chain complexes in mouse spinal cord sections , 2002, Journal of Neuroscience Methods.

[78]  N. Gonatas,et al.  The Golgi apparatus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions , 2002, Acta Neuropathologica.

[79]  J. Bender,et al.  Rapid vascular cell responses to estrogen and membrane receptors. , 2002, Vascular pharmacology.

[80]  L. Murri,et al.  Impaired oxidative metabolism in exercising muscle from ALS patients , 2001, Journal of the Neurological Sciences.

[81]  O. Gratzl,et al.  17β-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway , 2001, Brain Research.

[82]  T. Jessell,et al.  The status of Wnt signalling regulates neural and epidermal fates in the chick embryo , 2001, Nature.

[83]  Tomoki,et al.  N‐methyl‐D‐aspartate receptor‐mediated mitochondrial Ca2+ overload in acute excitotoxic motor neuron death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx , 2001 .

[84]  P N Leigh,et al.  Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil. , 2000, Brain : a journal of neurology.

[85]  Elizabeth Gould,et al.  Regulation of hippocampal neurogenesis in adulthood , 2000, Biological Psychiatry.

[86]  G. Pelletier.  Localization of androgen and estrogen receptors in rat and primate tissues. , 2000, Histology and histopathology.

[87]  M. Pinter,et al.  Functional motor unit failure precedes neuromuscular degeneration in canine motor neuron disease , 2000, Annals of neurology.

[88]  N. Gonatas,et al.  Fragmentation of the Golgi apparatus of the anterior horn cells in patients with familial amyotrophic lateral sclerosis with SOD1 mutations and posterior column involvement , 2000, Journal of the Neurological Sciences.

[89]  Imaharu Nakano,et al.  Frontotemporal dementia with motor neuron disease (amyotrophic lateral sclerosis with dementia) , 2000, Neuropathology : official journal of the Japanese Society of Neuropathology.

[90]  M. Mattson,et al.  ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis , 1999, Experimental Neurology.

[91]  T. Uchihara,et al.  Bunina bodies in amyotrophic lateral sclerosis on Guam: a histochemical, immunohistochemical and ultrastructural investigation , 1999, Acta Neuropathologica.

[92]  M. Figueiredo-Pereira,et al.  Ubiquitin, cellular inclusions and their role in neurodegeneration , 1998, Trends in Neurosciences.

[93]  T. Iwaki,et al.  Skein-like inclusions in the neostriatum from a case of amyotrophic lateral sclerosis with dementia , 1998, Acta Neuropathologica.

[94]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[95]  N. Gonatas,et al.  The involvement of the Golgi apparatus in the pathogenesis of amyotrophic lateral sclerosis, Alzheimer’s disease, and ricin intoxication , 1998, Histochemistry and Cell Biology.

[96]  F. Poccia,et al.  Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH‐SY5Y cells , 1997, FEBS letters.

[97]  H. Horvitz,et al.  Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis , 1997, Annals of neurology.

[98]  D. Schiffer,et al.  Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis , 1996, Journal of the Neurological Sciences.

[99]  C. Kenyon,et al.  Control of cell proliferation in the rat adrenal gland in vivo by the renin-angiotensin system. , 1996, The American journal of physiology.

[100]  F. Finiels,et al.  Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: an electromyographic study. , 1996, Neuroreport.

[101]  W. Hung,et al.  Intense Superoxide Dismutase‐1 Immunoreactivity in Intracytoplasmic Hyaline Inclusions of Familial Amyotrophic Lateral Sclerosis with Posterior Column Involvement , 1996, Journal of neuropathology and experimental neurology.

[102]  M. Iwata,et al.  Ultrastructural study of synapses in the anterior horn neurons of patients with amyotrophic lateral sclerosis , 1996, Neuroscience Letters.

[103]  L. Henderson,et al.  Androgen regulation of neuromuscular junction structure and function in a sexually dimorphic muscle of the frog Xenopus laevis. , 1995, Journal of neurobiology.

[104]  S H Appel,et al.  Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. , 1995, Brain : a journal of neurology.

[105]  V. Meininger,et al.  Superoxide dismutase activity in lymphoblastoid cells from motor neurone disease/amyotrophic lateral sclerosis (MND/ALS) patients , 1995, Journal of the Neurological Sciences.

[106]  M. Beal,et al.  Bioenergetic and oxidative stress in neurodegenerative diseases. , 1995, Life sciences.

[107]  T. Umahara,et al.  Cu Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis , 1994, Neuroscience Letters.

[108]  J. Buckwalter,et al.  Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects. , 1994, Archives of neurology.

[109]  K. Aihara,et al.  Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. , 1994, European journal of pharmacology.

[110]  S. Hirai,et al.  Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum , 1993, Neuroscience Letters.

[111]  C. Woolley,et al.  Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat , 1993, The Journal of comparative neurology.

[112]  G. Brewer,et al.  Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination , 1993, Journal of neuroscience research.

[113]  K. Kataoka,et al.  Steroid hormones protect spinal cord neurons from glutamate toxicity , 1993, Neuroscience.

[114]  S. Maruyama,et al.  Ultrastructural study of Bunina bodies in the anterior horn neurons of patients with amyotrophic lateral sclerosis , 1993, Neuroscience Letters.

[115]  H. Sasano,et al.  Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[116]  H. Kusaka,et al.  Ubiquitin-positive inclusion in anterior horn cells in subgroups of motor neuron diseases: A comparative study of adult-onset amyotrophic lateral sclerosis, juvenile amyotrophic lateral sclerosis and werdnig-hoffmann disease , 1993, Journal of the Neurological Sciences.

[117]  L. Whalley,et al.  Epidemiology of Alzheimer's presenile dementia in Scotland, 1974-88. , 1993, BMJ.

[118]  A. Hays,et al.  Peripherin and Neurofilament Protein Coexist in Spinal Spheroids of Motor Neuron Disease , 1992, Journal of neuropathology and experimental neurology.

[119]  P. Mcgeer,et al.  Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. , 1992, The American journal of pathology.

[120]  H. Kawakami,et al.  A unique pattern of astrocytosis in the primary motor area in amyotrophic lateral sclerosis , 1991, Acta Neuropathologica.

[121]  W. Pulsinelli,et al.  Acid-induced death in neurons and glia , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[122]  S. Natori,et al.  Effect of insulin, glucagon or dexamethasone on the production of insulin-like growth factor I in cultured rat hepatocytes. , 1991, Fukuoka igaku zasshi = Hukuoka acta medica.

[123]  M. Swash,et al.  Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity. , 1991, Brain : a journal of neurology.

[124]  W. Bleisch,et al.  Androgens modulate endplate size and ACh receptor density at synapses in rat levator ani muscle. , 1989, Journal of neurobiology.

[125]  S. Miller,et al.  Protirelin (thyrotropin-releasing hormone) in amyotrophic lateral sclerosis. The role of androgens. , 1989, Archives of neurology.

[126]  D. Perl,et al.  Accumulation of Phosphorylated Neurofilaments in Anterior Horn Motoneurons of Amyotrophic Lateral Sclerosis Patients , 1988, Journal of neuropathology and experimental neurology.

[127]  Anthony F. Jorm,et al.  The prevalence of dementia: A quantitative integration of the literature , 1987, Acta psychiatrica Scandinavica.

[128]  H. Hayashi.  Lactic dehydrogenase activities in single motoneurons in relation to amyotrophic lateral sclerosis , 1987, Journal of the Neurological Sciences.

[129]  G. Montgomery,et al.  Neuropsychological perspectives in amyotrophic lateral sclerosis. , 1987, Neurologic clinics.

[130]  M. Hadfield,et al.  Anterior Horn Changes of Motor Neuron Disease Associated with Demyelinating Radiculopathy , 1986, Journal of neuropathology and experimental neurology.

[131]  J. Sanes,et al.  Axon guidance during reinnervation of skeletal muscle , 1985, Trends in Neurosciences.

[132]  V. Luine,et al.  Testosterone increases acetylcholine receptor number in the "levator ani" muscle of the rat. , 1982, Journal of neurobiology.

[133]  S H Appel,et al.  A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease , 1981, Annals of neurology.

[134]  A. Scheibel,et al.  Degeneration of the human Betz cell due to amyotrophic lateral sclerosis , 1979, Experimental Neurology.

[135]  I. Kahán,et al.  Lactate dehydrogenase isoenzyme pattern in the eye muscles. Deviation in myopia. , 1976, The British journal of ophthalmology.

[136]  E. Frank,et al.  The interaction between foreign and original motor nerves innervating the soleus muscle of rats. , 1975, The Journal of physiology.

[137]  E. Robins,et al.  QUANTITATIVE HISTOCHEMICAL STUDIES OF THE HYPOTHALAMUS DEHYDROGENASE ENZYMES , 1974, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[138]  F. Collins,et al.  Principles of Biochemistry , 1937, The Indian Medical Gazette.

[139]  A. Ludolph,et al.  Amyotrophic lateral sclerosis. , 2012, Current opinion in neurology.

[140]  J. Lowe,et al.  The new neuropathology of degenerative frontotemporal dementias , 2009, Acta Neuropathologica.

[141]  C. Sfagos,et al.  Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis. , 2008, In vivo.

[142]  Mari Yoshida,et al.  alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. , 2005, Acta neuropathologica.

[143]  Christoph Schmitz,et al.  Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS , 2005, Nature Neuroscience.

[144]  Y. Ihara,et al.  Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis , 2004, Acta Neuropathologica.

[145]  N. Mahy,et al.  In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death , 2004, Hippocampus.

[146]  S. Maruyama,et al.  Immunocytochemical and ultrastructural studies of the motor cortex in amyotrophic lateral sclerosis , 2004, Acta Neuropathologica.

[147]  R. Martins,et al.  Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. , 2004, The Journal of biological chemistry.

[148]  S. Hirai,et al.  Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis , 2004, Acta Neuropathologica.

[149]  F. Udaka,et al.  Degeneration of betz cells in motor neuron disease. A Golgi study , 2004, Acta Neuropathologica.

[150]  J. Trojanowski,et al.  Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells , 2004, Acta Neuropathologica.

[151]  D. Troost,et al.  Neurofilament and glial alterations in the cerebral cortex in amyotrophic lateral sclerosis , 2004, Acta Neuropathologica.

[152]  R. Simerly.  Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. , 2002, Annual review of neuroscience.

[153]  S. Shimohama,et al.  N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx. , 2001, Journal of neuroscience research.

[154]  P. Leigh,et al.  The Molecular Pathology of Motor Neuron Disease , 1995 .

[155]  S. Aquilonius,et al.  Reactive gliosis and monoamine oxidase B. , 1994, Journal of neural transmission. Supplementum.

[156]  A. Goonetilleke,et al.  Motor neurone disease. , 1994, Essays in biochemistry.

[157]  内田 悦慈.  Effect of insulin, glucagon or dexamethasone on the production of apolipoprotein A-IV in cultured rat hepatocytes , 1992 .

[158]  A. Lapa,et al.  Androgen regulation of the nicotinic acetylcholine receptor-ionic channel in a hormone-dependent skeletal muscle. , 1991, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[159]  M. Haine,et al.  Van Damme A. , 1986 .

[160]  Hughes Jt,et al.  Pathology of amyotrophic lateral sclerosis. , 1982 .

[161]  J. Hughes.  Pathology of amyotrophic lateral sclerosis. , 1982, Advances in neurology.