论文信息 - Pregnancy outcome in women with factor V Leiden and recurrent miscarriage

Pregnancy outcome in women with factor V Leiden and recurrent miscarriage

We compared the outcome of 25 untreated pregnancies among women with recurrent miscarriage (RM) at <12 weeks’ gestation who were heterozygous for factor V Leiden with women with unexplained RM. The livebirth rate was lower among pregnancies in carriers of factor V Leiden (12/25; 48%) compared with pregnancies in women with unexplained RM (175/307; 57%), but the difference did not reach statistical significance. The best possible treatment regimen to improve livebirth rate in this group of women needs to be assessed in the form of a randomised controlled trial.

M. Makris | S. Saravelos | S. Jivraj | T. Li

[1] I. Milsom,et al. A prospective longitudinal population‐based study of clinical miscarriage in an urban Swedish population , 2007, BJOG : an international journal of obstetrics and gynaecology.

[2] R. Westrick,et al. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers , 2007, The Journal of experimental medicine.

[3] L. Regan,et al. Genetic thrombophilic mutations among couples with recurrent miscarriage. , 2006, Human reproduction.

[4] B. Isermann,et al. The thrombomodulin–protein C system is essential for the maintenance of pregnancy , 2003, Nature Medicine.

[5] L. Regan,et al. Factor V Leiden and recurrent miscarriage-prospective outcome of untreated pregnancies. , 2002, Human reproduction.