Waveform generation by enzymatic oscillators

The control of cell chemistry is being investigated through a multipronged approach combining the techniques of physics, chemistry, and biology with the development of electronic instrumentation and the application of analog and digital computers. An example of such metabolic control phenomena is provided by biological oscillators involving enzymatic reactions. These oscillators, which may exist in nearly every kind of cell and even in several forms in a single cell, reveal basic instabilities in biochemical reactions and metabolic control that may be of significance to health and disease. In addition, the high-frequency oscillations observed in simple enzyme systems may be models for the longer-period rhythms that regulate the activities of nearly all biological systems.

[1]  H. Nyquist,et al.  The Regeneration Theory , 1954, Journal of Fluids Engineering.

[2]  D. W. Bronk,et al.  THE TRANSMISSION OF TRAINS OF IMPULSES THROUGH A SYMPATHETIC GANGLION AND IN ITS POSTGANGLIONIC NERVES , 1938 .

[3]  R. Schoenfeld,et al.  Invariants in Experimental Data on Linear Kinetics and the Formulation of Models , 1956 .

[4]  B. Chance,et al.  Highly Sensitive Recording Microspectrophotometer , 1959 .

[5]  E. F. Macnichol,et al.  An Analog Computer to Simulate Systems of Coupled Bimolecular Reactions , 1959, Proceedings of the IRE.

[6]  B. Chance,et al.  Localization and kinetics of reduced pyridine nucleotide in living cells by microfluorometry. , 1959, The Journal of biological chemistry.

[7]  C. P. Richter,et al.  BIOLOGICAL CLOCKS IN MEDICINE AND PSYCHIATRY: SHOCK-PHASE HYPOTHESIS. , 1960, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. W. Hastings,et al.  The Action Spectrum for Shifting the Phase of the Rhythm of Luminescence in Gonyaulax polyedra , 1960, The Journal of general physiology.

[9]  A. Ghosh,et al.  Oscillations of glycolytic intermediates in yeast cells. , 1964, Biochemical and biophysical research communications.

[10]  B. Chance,et al.  Control of oscillations of the DPNH level in a cell-free extract of Saccharomyces carlsbergensis by 3′ 5′ cyclic AMP , 1964 .

[11]  B. Chance,et al.  CYCLIC AND OSCILLATORY RESPONSES OF METABOLIC PATHWAYS INVOLVING CHEMICAL FEEDBACK AND THEIR COMPUTER REPRESENTATIONS * , 1964, Annals of the New York Academy of Sciences.

[12]  B. Chance,et al.  CONTROL OF THE WAVEFORM OF OSCILLATIONS OF THE REDUCED PYRIDINE NUCLEOTIDE LEVEL IN A CELL-FREE EXTRACT. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Ghosh,et al.  DAMPED SINUSOIDAL OSCILLATIONS OF CYTOPLASMIC REDUCED PYRIDINE NUCLEOTIDE IN YEAST CELLS. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Frenkel.  DPNH oscillations in glycolyzing cell free extracts from beef heart. , 1965, Biochemical and biophysical research communications.

[15]  B. Chance,et al.  PHASE RELATIONSHIP OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS WITH OSCILLATORY METABOLIC CONTROL. , 1965, Archives of biochemistry and biophysics.

[16]  F. Halberg,et al.  Spectral resolution of low-frequency, small-amplitude rhythms in excreted 17-ketosteroids; probable androgen-induced circaseptan desynchronization. , 1965, Acta endocrinologica.

[17]  B. Chance,et al.  METABOLIC CONTROL PHENOMENA INVOLVED IN DAMPED SINUSOIDAL OSCILLATIONS OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE IN A CELL-FREE EXTRACT OF SACCHAROMYCES CARLSBERGENSIS. , 1965, The Journal of biological chemistry.

[18]  B. Chance,et al.  INFLUENCE OF INHIBITORS AND TEMPERATURE ON THE OSCILLATION OF REDUCED PYRIDINE NUCLEOTIDES IN YEAST CELLS. , 1965, Archives of biochemistry and biophysics.

[19]  R. Frenkel.  Reduced diphosphopyridine nucleotide oscillations in cell-free extracts from beef heart. , 1966, Archives of biochemistry and biophysics.

[20]  K. Pye,et al.  Sustained sinusoidal oscillations of reduced pyridine nucleotide in a cell-free extract of Saccharomyces carlsbergensis. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Higgins.  The Theory of Oscillating Reactions - Kinetics Symposium , 1967 .

[22]  A. Winfree.  Biological rhythms and the behavior of populations of coupled oscillators. , 1967, Journal of theoretical biology.