Design and fabrication of a new micro-injector driven by piezoelectric actuator

This paper presents the design, fabrication and testing of a micro-injector for precision injection of biological cells. Based on the specifications on travel range and injection speed, a single-axis translational motion mechanism is designed by using flexure mechanisms for precision motion guiding of the micro-injector. The mechanism parameters are designed and optimized to cater for the requirements on injection performance. The mechanism performance is verified by conducting finite element analysis simulations. A prototype micro-injector actuated by a piezoelectric stack actuator is developed for experimental testing. A feedback controller is implemented to guarantee the positioning accuracy and response speed. Experiment results reveal the satisfactory performance of the developed micro-injector.

[1]  Su Xiu-ping Output Displacement Analysis of Single Parallel Four-Bar Mechanism with Right Angle Flexure Hinge , 2009 .

[2]  Qingsong Xu,et al.  New Flexure Parallel-Kinematic Micropositioning System With Large Workspace , 2012, IEEE Transactions on Robotics.

[3]  Dong Sun,et al.  A new piezo-driven ultrasonic cell microinjection system , 2010, The 2010 IEEE International Conference on Information and Automation.

[4]  Yun Li,et al.  PID control system analysis, design, and technology , 2005, IEEE Transactions on Control Systems Technology.

[5]  Yulong Zhang,et al.  Design and control of a novel piezo-driven micro-injector , 2015, 2015 IEEE International Conference on Robotics and Biomimetics (ROBIO).

[6]  William L. Luyben,et al.  Simple method for tuning SISO controllers in multivariable systems , 1986 .

[7]  Haibo Huang,et al.  Optimal design of a new structure piezo-driven cell injector , 2014, 14th IEEE International Conference on Nanotechnology.

[8]  Jin U. Kang,et al.  Optical-Sensor Guided Intelligent Micro-injector for Retinal Therapy , 2014 .