Mechanical bioeffects of ultrasound.

Ultrasound is used widely in medicine as both a diagnostic and therapeutic tool. Through both thermal and nonthermal mechanisms, ultrasound can produce a variety of biological effects in tissues in vitro and in vivo. This chapter provides an overview of the fundamentals of key nonthermal mechanisms for the interaction of ultrasound with biological tissues. Several categories of mechanical bioeffects of ultrasound are then reviewed to provide insight on the range of ultrasound bioeffects in vivo, the relevance of these effects to diagnostic imaging, and the potential application of mechanical bioeffects to the design of new therapeutic applications of ultrasound in medicine.

[1]  A. J. Averbuch,et al.  PRIMARY METHOD FOR THE DETERMINATION OF ULTRASONIC INTENSITY WITH THE ELASTIC SPHERE-RADIOMETER. , 1977 .

[2]  Wesley L. Nyborg,et al.  Acoustic Radiation Pressure in a Traveling Plane Wave , 1972 .

[3]  D. Dalecki,et al.  Thresholds for premature contractions in murine hearts exposed to pulsed ultrasound. , 1997, Ultrasound in medicine & biology.

[4]  K. S. Norrell,et al.  Temporal and spatial evaluation of lesion reparative responses following superthreshold exposure of rat lung to pulsed ultrasound. , 2001, Ultrasound in medicine & biology.

[5]  R S Meltzer,et al.  Hemolysis in vivo from exposure to pulsed ultrasound. , 1997, Ultrasound in medicine & biology.

[6]  E. Carstensen,et al.  The search for cavitation in vivo. , 2000, Ultrasound in medicine & biology.

[7]  G. Steinbeck,et al.  Biological effects of shock waves: induction of arrhythmia in piglet hearts. , 1994, Ultrasound in medicine & biology.

[8]  C. Francis,et al.  Enhancement of fibrinolysis with 40-kHz ultrasound. , 1998, Circulation.

[9]  E. E. Shchekanov,et al.  A study of reception with the use of focused ultrasound. II. Effects on the animal receptor structures , 1977, Brain Research.

[10]  R F Kilcoyne,et al.  Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. , 1994, The Journal of bone and joint surgery. American volume.

[11]  E. Carstensen,et al.  Intestinal hemorrhage from exposure to pulsed ultrasound. , 1995, Ultrasound in medicine & biology.

[12]  L. Frizzell,et al.  Effect of pulse polarity and energy on ultrasound-induced lung hemorrhage in adult rats , 2003 .

[13]  R. M. Thomas,et al.  Thresholds for hemorrhages in mouse skin and intestine induced by lithotripter shock waves. , 1995, Ultrasound in medicine & biology.

[14]  P A van Der Wouw,et al.  Premature ventricular contractions during triggered imaging with ultrasound contrast. , 2000, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[15]  E. Carstensen,et al.  Thresholds for fetal hemorrhages produced by a piezoelectric lithotripter. , 1997, Ultrasound in medicine & biology.

[16]  K. Tachibana,et al.  Use of Ultrasound to Enhance the Local Anesthetic Effect of Topically Applied Aqueous Lidocaine , 1993, Anesthesiology.

[17]  L. Frizzell,et al.  Superthreshold behavior and threshold estimation of ultrasound-induced lung hemorrhage in pigs: Role of age dependency , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[18]  Ji Song,et al.  Stimulation of Arteriogenesis in Skeletal Muscle by Microbubble Destruction With Ultrasound , 2002, Circulation.

[19]  Peng Li,et al.  Impact of myocardial contrast echocardiography on vascular permeability: an in vivo dose response study of delivery mode, pressure amplitude and contrast dose. , 2003, Ultrasound in medicine & biology.

[20]  W. Cooney,et al.  External Fixation of High‐Energy Upper Extremity Injuries , 1990, Journal of orthopaedic trauma.

[21]  R. M. Thomas,et al.  Heating as a mechanism for ultrasonically-induced petechial hemorrhages in mouse intestine. , 1994, Ultrasound in medicine & biology.

[22]  K. Tachibana,et al.  Enhancement of fibrinolysis with ultrasound energy. , 1992, Journal of vascular and interventional radiology : JVIR.

[23]  E. Carstensen,et al.  Pressure threshold for shock wave induced renal hemorrhage. , 1990, The Journal of urology.

[24]  G. Kossoff Balance Technique for the Measurement of Very Low Ultrasonic Power Outputs , 1965 .

[25]  Takahi Hasegawa,et al.  Acoustic radiation force on fused silica spheres, and intensity determination , 1975 .

[26]  B. Baxter,et al.  Microbubble Potentiated Ultrasound as a Method of Declotting Thrombosed Dialysis Grafts: Experimental Study in Dogs , 2001, CardioVascular and Interventional Radiology.

[27]  L R Gavrilov,et al.  Use of amplitude-modulated focused ultrasound for diagnosis of hearing disorders. , 1988, Ultrasound in medicine & biology.

[28]  P. T. Onundarson,et al.  Enhancement of fibrinolysis in vitro by ultrasound. , 1992, The Journal of clinical investigation.

[29]  E. Carstensen,et al.  Effects of pulsed ultrasound on the frog heart: I. Thresholds for changes in cardiac rhythm and aortic pressure. , 1993, Ultrasound in medicine & biology.

[30]  William D O'Brien,et al.  Arrhythmias in Rat Hearts Exposed to Pulsed Ultrasound After Intravenous Injection of a Contrast Agent , 2002, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[31]  E. Carstensen,et al.  Albunex Does Not Increase the Sensitivity of the Lung to Pulsed Ultrasound , 1997, Echocardiography.

[32]  M. Dyson,et al.  Stimulation of bone repair by ultrasound. , 1985, Ultrasound in medicine & biology.

[33]  E. Carstensen,et al.  Ultrasonically induced lung hemorrhage in young swine. , 1997, Ultrasound in medicine & biology.

[34]  J. G. Miller,et al.  A novel site-targeted ultrasonic contrast agent with broad biomedical application. , 1996, Circulation.

[35]  T. Leighton The Acoustic Bubble , 1994 .

[36]  E. Unger,et al.  Local drug and gene delivery through microbubbles. , 2001, Progress in cardiovascular diseases.

[37]  E. Carstensen,et al.  Effects of pulsed ultrasound on the frog heart: II. An investigation of heating as a potential mechanism. , 1993, Ultrasound in medicine & biology.

[38]  N S El-Said,et al.  Selective release of the flexor origin with transfer of flexor carpi ulnaris in cerebral palsy. , 2001, The Journal of bone and joint surgery. British volume.

[39]  E. Carstensen,et al.  Lung damage from exposure to the fields of an electrohydraulic lithotripter. , 1990, Ultrasound in medicine & biology.

[40]  E. Carstensen,et al.  Tactile perception of ultrasound. , 1995, The Journal of the Acoustical Society of America.

[41]  L. Frizzell,et al.  Superthreshold behavior and threshold estimation of ultrasound-induced lung hemorrhage in adult mice and rats , 2001, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[42]  E. Carstensen,et al.  Exposure-time dependence of the threshold for ultrasonically induced murine lung hemorrhage. , 1996, Ultrasound in medicine & biology.

[43]  H. G. Flynn Generation of transient cavities in liquids by microsecond pulses of ultrasound , 1982 .

[44]  E. Carstensen,et al.  Age dependence of ultrasonically induced lung hemorrhage in mice. , 1997, Ultrasound in medicine & biology.

[45]  L. Frizzell,et al.  Superthreshold behavior and threshold estimates of ultrasound-induced lung hemorrhage in adult rats: role of beamwidth , 2001, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[46]  J. Ryaby,et al.  Accelerated Healing of Distal Radial Fractures with the Use of Specific, Low-Intensity Ultrasound. A Multicenter, Prospective, Randomized, Double-Blind, Placebo-Controlled Study* , 1997, The Journal of bone and joint surgery. American volume.

[47]  E. Carstensen,et al.  Effects of pulsed ultrasound on the frog heart: III. The radiation force mechanism. , 1997, Ultrasound in medicine & biology.

[48]  K. Tachibana Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure , 1992, Pharmaceutical Research.

[49]  J. Wojtczak,et al.  Lack of lung hemorrhage in humans after intraoperative transesophageal echocardiography with ultrasound exposure conditions similar to those causing lung hemorrhage in laboratory animals. , 1998, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[50]  D. Miller,et al.  Gas-body-based contrast agent enhances vascular bioeffects of 1.09 MHz ultrasound on mouse intestine. , 1998, Ultrasound in medicine & biology.

[51]  J. Zachary,et al.  Lung Lesions Induced by Continuous- and Pulsed-Wave (Diagnostic) Ultrasound in Mice, Rabbits, and Pigs , 1995, Veterinary pathology.

[52]  W. Brendel,et al.  Biological effects of shock waves: kidney damage by shock waves in dogs--dose dependence. , 1988, Ultrasound in medicine & biology.

[53]  R. Apfel,et al.  Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. , 1991, Ultrasound in medicine & biology.

[54]  E. Carstensen,et al.  Thresholds for intestinal hemorrhage in mice exposed to a piezoelectric lithotripter. , 1995, Ultrasound in medicine & biology.

[55]  D. Miller,et al.  Diagnostic Ultrasound Activation of Contrast Agent Gas Bodies Induces Capillary Rupture in Mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[56]  E. Carstensen,et al.  A test for cavitation as a mechanism for intestinal hemorrhage in mice exposed to a piezoelectric lithotripter. , 1996, Ultrasound in medicine & biology.

[57]  A. Pilla,et al.  Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. , 1990, Journal of orthopaedic trauma.

[58]  E. Unger,et al.  Therapeutic applications of microbubbles. , 2002, European journal of radiology.

[59]  D. Miller,et al.  The influence of ultrasound frequency and gas-body composition on the contrast agent-mediated enhancement of vascular bioeffects in mouse intestine. , 2000, Ultrasound in medicine & biology.

[60]  Leonid R. Gavrilov,et al.  A study of reception with the use of focused ultrasound. I. Effects on the skin and deep receptor structures in man , 1977, Brain Research.

[61]  E. Carstensen,et al.  Thresholds for ultrasonically induced lung hemorrhage in neonatal swine. , 1996, Ultrasound in medicine & biology.

[62]  M. Fishbein,et al.  Noninvasive in vivo clot dissolution without a thrombolytic drug: recanalization of thrombosed iliofemoral arteries by transcutaneous ultrasound combined with intravenous infusion of microbubbles. , 1998, Circulation.

[63]  M. Jordan,et al.  Biological effects of shock waves: kidney haemorrhage by shock waves in dogs--administration rate dependence. , 1988, Ultrasound in medicine & biology.

[64]  A. Klibanov,et al.  Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging. , 1999, Advanced drug delivery reviews.

[65]  L. Gavrilov,et al.  Use of focused ultrasound for stimulation of nerve structures. , 1984, Ultrasonics.

[66]  E. Carstensen,et al.  Bioeffects of positive and negative acoustic pressures in vivo. , 1996, The Journal of the Acoustical Society of America.

[67]  P. Dayton,et al.  Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles. , 1999, Ultrasound in medicine & biology.

[68]  D. Miller,et al.  Consequences of lithotripter shockwave interaction with gas body contrast agent in mouse intestine. , 1999, The Journal of urology.

[69]  J. A. Rooney Determination of acoustic power outputs in the microwatt-milliwatt range , 1973 .

[70]  K R Foster,et al.  Auditory responses in cats produced by pulsed ultrasound. , 1978, The Journal of the Acoustical Society of America.

[71]  M. Jordan,et al.  Biological effects of shock waves: cavitation by shock waves in piglet liver. , 1990, Ultrasound in medicine & biology.

[72]  J F Greenleaf,et al.  Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. , 1998, Ultrasound in medicine & biology.

[73]  M. Fishbein,et al.  Transcutaneous ultrasound augments lysis of arterial thrombi in vivo. , 1996, Circulation.

[74]  G E Trahey,et al.  A novel ultrasonic technique for differentiating cysts from solid lesions: preliminary results in the breast. , 1995, Ultrasound in medicine & biology.

[75]  E. Carstensen,et al.  Lung damage from exposure to pulsed ultrasound. , 1990, Ultrasound in medicine & biology.

[76]  M. Jordan,et al.  Biological effects of shock waves: effect of shock waves on the liver and gallbladder wall of dogs--administration rate dependence. , 1990, Ultrasound in medicine & biology.

[77]  C. Cox,et al.  Hemorrhage in murine fetuses exposed to pulsed ultrasound. , 1999, Ultrasound in medicine & biology.

[78]  Rita J. Miller,et al.  Ultrasound-induced lung hemorrhage: role of acoustic boundary conditions at the pleural surface. , 2002, The Journal of the Acoustical Society of America.

[79]  E. Carstensen,et al.  Bioeffects of positive and negative acoustic pressures in mice infused with microbubbles. , 2000, Ultrasound in medicine & biology.

[80]  K. Hynynen The threshold for thermally significant cavitation in dog's thigh muscle in vivo. , 1991, Ultrasound in medicine & biology.

[81]  K. Tachibana,et al.  Prototype therapeutic ultrasound emitting catheter for accelerating thrombolysis. , 1997, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[82]  E. Carstensen,et al.  Morphological effects of pulsed ultrasound in the lung. , 1993, Ultrasound in medicine & biology.

[83]  E. Carstensen,et al.  Remnants of Albunex nucleate acoustic cavitation. , 1997, Ultrasound in medicine & biology.

[84]  H. Dittrich,et al.  Lack of bioeffects of ultrasound energy after intravenous administration of FS069 (Optison) in the anesthetized rabbit. , 1998, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[85]  Ji Song,et al.  Influence of injection site, microvascular pressure and ultrasound variables on microbubble-mediated delivery of microspheres to muscle. , 2002, Journal of the American College of Cardiology.

[86]  J. Saunders,et al.  The cavitation threshold of human tissue exposed to 0.2-MHz pulsed ultrasound: preliminary measurements based on a study of clinical lithotripsy. , 1995, Ultrasound in medicine & biology.

[87]  C. Rubin,et al.  The use of low-intensity ultrasound to accelerate the healing of fractures. , 2001, The Journal of bone and joint surgery. American volume.

[88]  E. Unger,et al.  Gene Delivery Using Ultrasound Contrast Agents , 2001, Echocardiography.

[89]  E. Carstensen,et al.  Timing of exposures in ultrasonic hemorrhage of murine lung. , 1993, Ultrasound in medicine & biology.

[90]  L. Frizzell,et al.  Threshold estimates and superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse duration. , 2003, Ultrasound in medicine & biology.

[91]  M. Dyson,et al.  Flow of Red Blood Cells stopped by Ultrasound , 1971, Nature.

[92]  A. Klibanov,et al.  Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats. , 2002, Ultrasound in medicine & biology.

[93]  K. Parker,et al.  Damage to murine kidney and intestine from exposure to the fields of a piezoelectric lithotripter. , 1994, Ultrasound in medicine & biology.

[94]  E. Carstensen,et al.  Thresholds for premature ventricular contractions in frog hearts exposed to lithotripter fields. , 1991, Ultrasound in medicine & biology.

[95]  L. R. Duarte The stimulation of bone growth by ultrasound , 2004, Archives of orthopaedic and traumatic surgery.

[96]  R. Cleveland,et al.  Comparison of electrohydraulic lithotripters with rigid and pressure-release ellipsoidal reflectors. II. Cavitation fields. , 1998, The Journal of the Acoustical Society of America.

[97]  J. Zachary,et al.  Lung damage assessment from exposure to pulsed-wave ultrasound in the rabbit, mouse, and pig , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[98]  D. Uphoff,et al.  Applications of lipid-coated microbubble ultrasonic contrast to tumor therapy. , 1993, Ultrasound in medicine & biology.

[99]  Leon A. Frizzell,et al.  American Institute of Ultrasound in Medicine , 1983 .

[100]  L. Frizzell,et al.  Superthreshold behavior of ultrasound-induced lung hemorrhage in adult mice and rats: role of pulse repetition frequency and exposure duration. , 2001, Ultrasound in medicine & biology.

[101]  R E Apfel,et al.  Direct evidence of cavitation in vivo from diagnostic ultrasound. , 1996, Ultrasound in medicine & biology.

[102]  A. Tarantal,et al.  Ultrasound-induced lung hemorrhage in the monkey. , 1994, Ultrasound in medicine & biology.

[103]  L. Frizzell,et al.  Ultrasound-induced lung hemorrhage is not caused by inertial cavitation. , 2000, The Journal of the Acoustical Society of America.

[104]  L. Crum,et al.  Image-guided acoustic therapy. , 2001, Annual review of biomedical engineering.

[105]  T C Skalak,et al.  Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. , 1998, Circulation.

[106]  S. Mitragotri,et al.  Ultrasound-mediated transdermal protein delivery , 1995, Science.

[107]  E. Carstensen,et al.  The influence of contrast agents on hemorrhage produced by lithotripter fields. , 1997, Ultrasound in medicine & biology.