Reference based simulation study of detector comparison for BNCT-SPECT imaging

Abstract To investigate the optimal detector material for prompt gamma imaging during boron neutron capture therapy, in this study, we evaluated the characteristic regarding radiation reaction of available detector materials using a Monte Carlo simulation. Sixteen detector materials used for radiation detection were investigated to assess their advantages and drawbacks. The estimations used previous experimental data to build the simulation codes. The energy resolution and detection efficiency of each material was investigated, and prompt gamma images during BNCT simulation were acquired using only the detectors that showed good performance in our preliminary data. From the simulation, we could evaluate the majority of detector materials in BNCT and also could acquire a prompt gamma image using the six high ranked-detector materials and lutetium yttrium oxyorthosilicate. We provide a strategy to select an optimal detector material for the prompt gamma imaging during BNCT with three conclusions.

[1]  L J Meng,et al.  Exploring the limiting timing resolution for large volume CZT detectors with waveform analysis. , 2005, IEEE transactions on nuclear science.

[2]  B. Mijnheer,et al.  Monitoring of blood-10B concentration for boron neutron capture therapy using prompt gamma-ray analysis. , 1995, Acta oncologica.

[3]  I. Murata,et al.  Development of a thick CdTe detector for BNCT-SPECT. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[4]  Zhong He,et al.  Investigation of pixellated HgI2 γ-ray spectrometers , 2002 .

[5]  M.A. King,et al.  Theoretical and Numerical Study of MLEM and OSEM Reconstruction Algorithms for Motion Correction in Emission Tomography , 2009, IEEE Transactions on Nuclear Science.

[6]  A. Del Guerra,et al.  Simultaneous PET/SPECT imaging with the small animal scanner YAP-(S)PET , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[7]  H. Hatanaka,et al.  Boron neutron capture therapy: Clinical brain tumor studies , 1997, Journal of Neuro-Oncology.

[8]  F. Augustine,et al.  Performance measurements from LYSO scintillators coupled to a CMOS position sensitive SSPM detector , 2011 .

[9]  M. Moszynski,et al.  A high-energy resolution observed from a YAP : Ce scintillator , 1999 .

[10]  E. Brunckhorst Experimental investigations of the neutron contamination in high-energy photon fields at medical linear accelerators , 2009 .

[11]  E. Pozzi,et al.  Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases. , 2014, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[12]  Evaluation of a LiI(Eu) neutron detector with coincident double photodiode readout , 2011 .

[13]  J. Pouthas,et al.  Energy resolution of LaBr3:Ce in a phoswich configuration with CsI:Na and NaI:Tl scintillator crystals , 2012 .

[14]  M. Perona,et al.  Experimental Studies of Boronophenylalanine ((10)BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment. , 2015, International journal of radiation oncology, biology, physics.

[15]  J. Coderre,et al.  The radiation biology of boron neutron capture therapy. , 1999, Radiation research.

[16]  P. Chouraqui,et al.  A gamma camera based on CdTe detectors , 1996 .

[17]  A. Matsumura,et al.  Clinical review of the japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams , 2003, Journal of Neuro-Oncology.

[18]  Afaf R. Genady,et al.  New functionalized mercaptoundecahydrododecaborate derivatives for potential application in boron neutron capture therapy: synthesis, characterization and dynamic visualization in cells. , 2015, European journal of medicinal chemistry.

[19]  Yong Choi,et al.  MR insertable brain PET using tileable GAPD arrays , 2010, IEEE Nuclear Science Symposuim & Medical Imaging Conference.

[20]  D. Bortolato,et al.  Interaction position resolution simulations and in-beam measurements of the AGATA HPGe detectors , 2011 .

[21]  Seung-Min Park,et al.  Towards clinically translatable in vivo nanodiagnostics. , 2017, Nature reviews. Materials.

[22]  Shin Watanabe,et al.  Development of CdTe pixel detectors for Compton cameras , 2006 .

[23]  Hideo Onishi,et al.  Performance evaluation of OSEM reconstruction algorithm incorporating three-dimensional distance-dependent resolution compensation for brain SPECT: A simulation study , 2002, Annals of nuclear medicine.

[24]  I. Procházka,et al.  A high-resolution BaF2 positron-lifetime spectrometer and experience with its long-term exploitation , 2000 .

[25]  N. Hosmane,et al.  Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment , 2012 .

[26]  Do-Kun Yoon,et al.  GPU-based prompt gamma ray imaging from boron neutron capture therapy. , 2014, Medical physics.

[27]  L. Eriksson,et al.  Energy resolution and absolute detection efficiency for LSO crystals: A comparison between Monte Carlo simulation and experimental data , 2007 .

[28]  I. Murata,et al.  Study on measuring device arrangement of array-type CdTe detector for BNCT-SPECT. , 2016, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology.

[29]  Joo-Young Jung,et al.  Statistical analysis for discrimination of prompt gamma ray peak induced by high energy neutron: Monte Carlo simulation study , 2014, Journal of Radioanalytical and Nuclear Chemistry.

[30]  S. Green,et al.  First tomographic image of neutron capture rate in a BNCT facility. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[31]  Xiaobin Tang,et al.  Influence of Neutron Sources and 10B Concentration on Boron Neutron Capture Therapy for Shallow and Deeper Non-small Cell Lung Cancer , 2017, Health physics.

[32]  T. Matsumoto,et al.  Phantom experiment and calculation for in vivo 10boron analysis by prompt gamma ray spectroscopy. , 1991, Physics in medicine and biology.

[33]  A. Kreiner,et al.  Development of a Tomographic System for Online Dose Measurements in BNCT (Boron Neutron Capture Therapy) , 2005 .

[34]  M. Vicente,et al.  Boron Neutron Capture Therapy of Cancer: Current Status and Future Prospects , 2005, Clinical Cancer Research.

[35]  Joo-Young Jung,et al.  Application of proton boron fusion reaction to radiation therapy: A Monte Carlo simulation study , 2014 .

[36]  A. Paetau,et al.  Boron neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine , 2003, Journal of Neuro-Oncology.

[37]  P. Rosenschöld,et al.  Prompt gamma tomography during BNCT – a feasibility study , 2006 .

[38]  R. Barth,et al.  Boron neutron capture therapy of cancer. , 1990, Cancer research.

[39]  S. Baechler,et al.  Prompt gamma-ray activation analysis for determination of boron in aqueous solutions , 2002 .

[40]  S. Savolainen,et al.  Boron neutron capture therapy in the treatment of locally recurred head and neck cancer. , 2007, International journal of radiation oncology, biology, physics.

[41]  M. Hawthorne The Role of Chemistry in the Development of Boron Neutron Capture Therapy of Cancer , 1993 .

[42]  I. Murata,et al.  Characterization measurement of a thick CdTe detector for BNCT-SPECT - detection efficiency and energy resolution. , 2014, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[43]  T. Tanimori,et al.  Development of large area gamma-ray camera with GSO(Ce) scintillator arrays and PSPMTs , 2007 .

[44]  H. Nakashima,et al.  Construction of a BNCT Facility using an 8-MeV High Power Proton Linac in Tokai , 2012 .

[45]  J. Kalef-Ezra,et al.  Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR). , 1990, Basic life sciences.

[46]  H. Jang,et al.  Therapy region monitoring based on PET using 478 keV single prompt gamma ray during BNCT: A Monte Carlo simulation study. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[47]  E. Auffray,et al.  Comparison of LuAP and LuYAP crystal properties from statistically significant batches produced with two different growth methods , 2005 .

[48]  George Kontaxakis,et al.  PET image reconstruction: A stopping rule for the MLEM algorithm based on properties of the updating coefficients , 2010, Comput. Medical Imaging Graph..

[49]  Do-Kun Yoon,et al.  Prompt gamma ray imaging for verification of proton boron fusion therapy: A Monte Carlo study. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.